Results 61 to 70 of about 2,921 (152)

Early brain‐penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1‐related Aicardi‐Goutières syndrome

Clinical &Translational Immunology, Volume 15, Issue 7, 2026.
Abstract Objectives Aicardi‐Goutières syndrome (AGS) is a genetic interferonopathy resulting from defects in nucleic acid metabolism and subsequent enhanced type I interferon signalling. We report how an expedited genomic diagnosis in conjunction with natural history data can enable a long‐term brain‐penetrant anti‐inflammatory regimen to optimise ...
Russell C Dale, Jessica Hayes, Velda X Han, Ruwani Dissanayake, Xianzhong Lau, Michelle Farrar, Brian Gloss, Markus Hofer, Esther Tantsis, Michelle Lorentzos, Safiyyah Abbas, Yanick J Crow, Shekeeb Mohammad, Shrujna Patel   +13 more
wiley   +1 more source

Inhibition of prohibitin 2 enhances the sensitivity of non-small cell lung cancer cell line A549 to erlotinib [PDF]

Jichu yixue yu linchuang
Objective To explore the effects of prohibitin 2(PHB2) on sensitivity of non-small cell lung cancer cell line A549 to erlotinib (Erl) and its potential mechanisms.
ZHANG Jing, YANG Zigeng, CAI Wenqin, CAO Weiwei, WEI Hongmei, XUE Xixi, WU Bin
doaj   +1 more source

Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection

Viruses, 2020
Enterovirus A71 (EV-A71) is a major pathogen that causes severe and fatal cases of hand-foot-and-mouth disease (HFMD). HFMD caused by EV-A71 seriously endangers children’s health.
Weitao Su, Shan Huang, Huimin Zhu, Bao Zhang, Xianbo Wu   +4 more
doaj   +1 more source

PHB2 SF-12 Osteoarthritis-Specific Health Index: Development And Validation

Value in Health, 1998
OBJECTIVE:To develop and validate SF-12 osteoarthritis-specific health index (SF-12 OASHI). METHODS:Patient data on SF-12 and six osteoarthritis (OP) clinical variables (physician and patient global assessments, pain intensity, knee pain on weight bearing and motion, time to walk 50 feet) at baseline and week, 6, from two placebo-controlled ...
Gandhi, SK, Salmon, JW, Zhao, SZ, Lambert, BL, Gore, P, Conrad, K   +5 more
openaire   +1 more source

Multi‐Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre‐Frail Older Men by Losartan

Aging Cell, Volume 25, Issue 5, May 2026.
Losartan partially reversed serum metabolomic aging signatures in both aged mice and pre‐frail older men, and this effect required functional angiotensin II receptors in mice. Cross‐species analyses suggest aging shifts circulating metabolites in opposite directions in mice versus humans, particularly among lipids, with losartan partially normalizing ...
Michael R. Bene, Cissy Zhang, Reyhan Westbrook, Mariann Gabrawy, Ruth Marx, Yuqiong Wu, Mohammed Khadeer, Ceereena Ubaida‐Mohien, Luigi Ferrucci, Ruin Moaddel, Anne Le, Jeremy D. Walston, Jessica L. Lee, Peter M. Abadir   +13 more
wiley   +1 more source

Prx1/PHB2 axis mediates mitophagy in oral leukoplakia cellular senescence

Pathology - Research and Practice
Oral leukoplakia (OLK) is the most common oral potentially malignant disorder (OPMD), which can be malignantly transformed into oral squamous cell carcinoma (OSCC). Peroxiredoxin1(Prx1) has been predicted to bind to Prohibitin2 (PHB2), which confers to affect OLK progression; however, the mechanism of Prx1/PHB2 mediated mitophagy involved in OLK ...
Yunping, Lu, Lingyu, Li, Jing, Li, Min, Wang, Jing, Yang, Min, Zhang, Qingsong, Jiang, Xiaofei, Tang   +7 more
openaire   +2 more sources

Age‐Associated Impairment of Paneth Cells Driven by microRNA‐152 Promotes Intestinal Epithelial Vulnerability to Pathological Stress

Aging Cell, Volume 25, Issue 5, May 2026.
Aging associated miR‐152 dysregulation plays a central role in the loss of Paneth cell homeostasis by inhibiting mitochondrial protein Prohibitin1 (PHB1) expression, which contributes to increased small intestinal vulnerability to pathological stresses. ABSTRACT Advanced age is a well‐known risk factor for severe complications in surgical patients with
Bridgette Warner, Haonan Zhao, Hongxia Chen, Amy VanderStoep, Ana S. G. Cunningham, Dongyoon Yoo, Hee K. Chung, Christine Brantner, Jennifer Coleman, Joungil Choi, Rosemary Kozar, Myriam Gorospe, Jian‐Ying Wang, Lan Xiao   +13 more
wiley   +1 more source

Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells. [PDF]

PLoS ONE, 2012
Increase in mitochondrial biogenesis has been shown to accompany brown and white adipose cell differentiation. Prohibitins (PHBs), comprised of two evolutionarily conserved proteins, prohibitin-1 (PHB1) and prohibitin-2 (PHB2), are present in a high ...
Dong Liu, Yiming Lin, Ting Kang, Bo Huang, Wei Xu, Minerva Garcia-Barrio, Moshood Olatinwo, Roland Matthews, Y Eugene Chen, Winston E Thompson   +9 more
doaj   +1 more source

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

LINC00478-derived novel cytoplasmic lncRNA LacRNA stabilizes PHB2 and suppresses breast cancer metastasis via repressing MYC targets

Journal of Translational Medicine, 2023
Background Metastasis is the predominant cause of mortality in patients with breast cancer. Long noncoding RNAs (lncRNAs) have been shown to drive important phenotypes in tumors, including invasion and metastasis.
Rong Guo, Yonghui Su, Qi Zhang, Bingqiu Xiu, Sheng Huang, Weiru Chi, Liyi Zhang, Lun Li, Jianjing Hou, Jia Wang, Jiajian Chen, Yayun Chi, Jingyan Xue, Jiong Wu   +13 more
doaj   +1 more source