Results 61 to 70 of about 583 (139)

Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2

, 2021
Natural products have numerous bioactivities and are expected to be a resource for potent drugs. However, their direct targets in cells often remain unclear.
Motoki Watanabe, Michihiro Mutoh, Tomoshi Kameda, Yoichi Kurumida, Mamiko Sukeno, Shingo Miyamoto, Yoshihiro Sowa, Yosuke Iizumi, Hideki Takakura, Toshiyuki Sakai, Mahiro Iizuka-Ohashi, Yasumasa Yamada   +11 more
core   +1 more source

GALNT14-mediated O-glycosylation on PHB2 serine-161 enhances cell growth, migration and drug resistance by activating IGF1R cascade in hepatoma cells

Cell Death and Disease, 2022
The single nucleotide polymorphism (SNP) rs9679162 located on GALNT14 gene predicts therapeutic outcomes in patients with intermediate and advanced hepatocellular carcinoma (HCC), but the molecular mechanism remains unclear.
Yu-De Chu, Tan-Chi Fan, Ming-Wei Lai, Chau-Ting Yeh   +3 more
doaj   +1 more source

Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration

Andrology, Volume 14, Issue 6, Page 1579-1589, September 2026.
ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda, Jiřina Havránková, Hedvika Řimnáčová, Jiří Moravec, František Liška, Martin Knytl, Milena Králíčková, Jan Nevoral   +7 more
wiley   +1 more source

CaMKIIa-Cre-mediated inactivation of the mouse Phb2 gene in forebrain neurons.

, 2012
(A) In-situ hybridization of Phb2 mRNA in the hippocampus of 8-week-old Phb2NKO and Phb2fl/fl control mice. Scale bar: 500 µm. (B) Immunoblot analysis of tissue lysates generated from the indicated brain regions of Phb2NKO (KO) and Phb2fl/fl (WT) control
Anne Korwitz (122006), Sabine D. Jordan (122012), Michela Morbin (122009), Paola Martinelli (122001), Elena I. Rugarli (122017), Thomas Langer (122021), Hella S. Brönneke (102436), Carsten Merkwirth (121996)   +7 more
core   +1 more source

PHB2-mediated inhibition of OPA1 cleavage alleviates nonesterified fatty acid–induced apoptosis in bovine mammary epithelial cells

Journal of Dairy Science
: Excessive nonesterified fatty acids (NEFA) during the transition period impose metabolic stress on the bovine mammary gland. High NEFA levels induce oxidative stress and trigger apoptosis in bovine mammary epithelial cells.
Guojin Li, Qi Shao, Qingyan Yin, Kai Liu, Liguang Cao, Jianchun Luo, Depeng Li, Qianwen Sun, Lin Lei, Yuxiang Song, Xiliang Du, Xinwei Li, Guowen Liu, Wenwen Gao   +13 more
doaj   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

, 2019
Mitophagy, which is a conserved cellular process for selectively removing damaged or unwanted mitochondria, is critical for mitochondrial quality control and the maintenance of normal cellular physiology.
Li Chen (5749), Chaojun Yan (6816527), Meng Xu (62933), Laurent Désaubry (198619), Zhiyin Song (6816530), Hussein Abou-Hamdan (4837953), Mingliang Tang (390957), Longlong Gong (6308690)   +7 more
core   +1 more source

Inhibition of prohibitin 2 enhances the sensitivity of non-small cell lung cancer cell line A549 to erlotinib [PDF]

Jichu yixue yu linchuang
Objective To explore the effects of prohibitin 2(PHB2) on sensitivity of non-small cell lung cancer cell line A549 to erlotinib (Erl) and its potential mechanisms.
ZHANG Jing, YANG Zigeng, CAI Wenqin, CAO Weiwei, WEI Hongmei, XUE Xixi, WU Bin
doaj   +1 more source

Scalable discovery of homomeric protein–protein interactions from cross‐linking mass spectrometry data with CLAUDIO 2.0

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Cross‐linking mass spectrometry (XL‐MS) is a powerful biochemical approach for residue‐level characterization of protein structures and interactions under near‐native conditions. The growing scale of XL‐MS datasets demands scalable analysis pipelines that capture signals often overlooked in conventional workflows, including homomeric ...
Tobias Löser, Alexander Röhl, Markus Baier, Andrei Lupas, Oliver Kohlbacher, Hadeer Elhabashy   +5 more
wiley   +1 more source

Defective mitochondrial morphogenesis and ultrastructure in Phb2-deficient neurons in vivo.

, 2012
(A) Transmission electron microscopy analysis of the mitochondrial ultrastructure in DG neurons of 6-week-old Phb2NKO and Phb2fl/fl control mice. The enlargements show the double membrane of the mitochondrion and the emergence of one crista.
Anne Korwitz (122006), Sabine D. Jordan (122012), Michela Morbin (122009), Paola Martinelli (122001), Elena I. Rugarli (122017), Thomas Langer (122021), Hella S. Brönneke (102436), Carsten Merkwirth (121996)   +7 more
core   +1 more source