Results 81 to 90 of about 2,921 (152)

Corosolic acid attenuates cardiac ischemia/reperfusion injury through the PHB2/PINK1/parkin/mitophagy pathway

iScience
Summary: Despite advances in treatment, myocardial infarction remains the leading cause of heart failure and death worldwide, and the restoration of coronary blood flow can also cause heart damage.
Jun Zhang, Yongjian Zhao, Lin Yan, Mingyue Tan, Yifeng Jin, Yunfei Yin, Lianhua Han, Xiao Ma, Yimin Li, Tianke Yang, Tingbo Jiang, Hongxia Li   +11 more
doaj   +1 more source

PHB2 forms a mitochondrial calcium channel that drives Parkinson’s disease

Abstract Dysregulated mitochondrial Ca2+ influx is a unifying driver of neurodegeneration, compromising neuronal bioenergetics and survival. In Parkinson’s disease (PD), impaired mitochondrial Ca2+ uptake is a decisive trigger for dopaminergic (DA) neuron loss, yet the molecular identity of the responsible channel has remained ...
Zhou, Shu, Li, Yunyan, Fang, Yang, Yang, Jing, Liu, Yong, Wang, Yizhuo, Bai, Dongshuai, Gao, Yongxiang, Jiao, Ziying, Tang, Hengfang, Ji, Xinmiao, Song, Linlin, Richter, Christian, Mao, Wenping, Law, Betty, Schwalbe, Harald, Wang, Kai, Zhang, Xin, Shen, Bing, Wang, Junfeng   +19 more
openaire   +1 more source

Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.

PLoS Genetics, 2012
Fusion and fission of mitochondria maintain the functional integrity of mitochondria and protect against neurodegeneration, but how mitochondrial dysfunctions trigger neuronal loss remains ill-defined.
Carsten Merkwirth, Paola Martinelli, Anne Korwitz, Michela Morbin, Hella S Brönneke, Sabine D Jordan, Elena I Rugarli, Thomas Langer   +7 more
doaj   +1 more source

Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

Scientific Reports, 2017
Estradiol (E2) and the oestrogen receptor-alpha (ERα) signalling pathway play pivotal roles in the proliferative activity of breast cancer cells. Recent findings show that the brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-
Tetsuro Yoshimaru, Keisuke Aihara, Masato Komatsu, Yosuke Matsushita, Yasumasa Okazaki, Shinya Toyokuni, Junko Honda, Mitsunori Sasa, Yasuo Miyoshi, Akira Otaka, Toyomasa Katagiri   +10 more
doaj   +1 more source

Prohibitin 2 orchestrates long noncoding RNA and gene transcription to accelerate tumorigenesis

Nature Communications
The spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding genes contributes to malignancy development in various tumors. However, precise coordinated mechanisms underlying this phenomenon in tumorigenesis remains incompletely
Tianyi Ding, Haowen Xu, Xiaoyu Zhang, Fan Yang, Jixing Zhang, Yibing Shi, Yiran Bai, Jiaqi Yang, Chaoqun Chen, Chengbo Zhu, He Zhang   +10 more
doaj   +1 more source

PHB2 acts as a braker of progressive pulmonary fibrosis via intervention of DDR2-elicited signaling

Acta Biochimica et Biophysica Sinica
Idiopathic pulmonary fibrosis (IPF) is a fatal disease whose pathogenic mechanisms remain incompletely understood. Transforming growth factor-beta (TGF-β) is widely regarded as a central driver of fibrosis, orchestrating sustained fibroblast activation and pathological tissue scarring.
Penghui, Yang, Jinjun, Jiang, Jiani, Liu, Bing, Su, Xiaohua, Wang, Zhenli, Fu, Ying, He, Jing, Han, Chunrong, Ju, Yinuo, Wang, Xinpeng, Lu, Xiaomin, Peng, Hang, Yin, Junqi, Li, Dandan, Wang, Jianping, Liu, Yunxin, Lai, Jin, Su   +17 more
openaire   +2 more sources

High glucose- or AGE-induced oxidative stress inhibits hippocampal neuronal mitophagy through the Keap1–Nrf2–PHB2 pathway in diabetic encephalopathy

Scientific Reports
Diabetic encephalopathy (DE) is a severe complication of diabetes, but its pathogenesis remains unclear. This study aimed to investigate the roles and underlying mechanisms of high glucose (HG)- and advanced glycosylation end product (AGE)-induced ...
Shan Xu, Zhaoyu Gao, Lei Jiang, Jiazheng Li, Yushi Qin, Di Zhang, Pei Tian, Wanchang Wang, Nan Zhang, Rui Zhang, Shunjiang Xu   +10 more
doaj   +1 more source

GOLPH3 promotes glioma progression by enhancing PHB2-mediated autophagy.

American journal of cancer research
Due to the hypoxia and nutrient deficiency microenvironment, malignant glioma exhibits high autophagy activity and autophagy plays a significant role in the occurrence and development of glioma. However, the potential molecular mechanism of autophagy in glioma remains unknown. In this study, we demonstrated that Golgi phosphorylation protein 3 (GOLPH3),
Kai, Wang, Yanhua, Qi, Xu, Wang, Yushuai, Liu, Min, Zhao, Ding, Zhou, Yu, Zhang, Yan, Wang, Rutong, Yu, Xiuping, Zhou   +9 more
openaire   +1 more source

Phb1:Phb2 heterodimers in the mitochondria—beyond functional interdependence [PDF]

Journal of Biological Chemistry, 2019
openaire   +2 more sources

AURKA/PHB2 signaling drives acquired resistance to KRAS ^G12C inhibitors in KRAS ^G12C-mutant NSCLC. [PDF]

Cell Death Discov
Liao J, Lan X, Chen Z, Hu D, Luo D, He H, Huang Z, Yu H, Bai Y, Luo X, Lin X.   +10 more
europepmc   +1 more source