Results 81 to 90 of about 583 (139)

Age‐Associated Impairment of Paneth Cells Driven by microRNA‐152 Promotes Intestinal Epithelial Vulnerability to Pathological Stress

Aging Cell, Volume 25, Issue 5, May 2026.
Aging associated miR‐152 dysregulation plays a central role in the loss of Paneth cell homeostasis by inhibiting mitochondrial protein Prohibitin1 (PHB1) expression, which contributes to increased small intestinal vulnerability to pathological stresses. ABSTRACT Advanced age is a well‐known risk factor for severe complications in surgical patients with
Bridgette Warner, Haonan Zhao, Hongxia Chen, Amy VanderStoep, Ana S. G. Cunningham, Dongyoon Yoo, Hee K. Chung, Christine Brantner, Jennifer Coleman, Joungil Choi, Rosemary Kozar, Myriam Gorospe, Jian‐Ying Wang, Lan Xiao   +13 more
wiley   +1 more source

Ectopic expression of PHB2 promotes cell proliferation of mouse pluripotent mouse ES cells.

, 2014
(A, B) Ectopic expression of PHB2 under the control of a Tet-off promoter. EBRTcH3 cells carrying the PHB2 target gene under the control of a tetracycline (Tc)-regulated promoter were cultured with or without Tc for 4 days, and subjected to ...
Ying Ying Wang (548374), Pi-Chao Wang (548384), Kanako Watanabe-Susaki (548370), Naoto Ninomiya (548376), Akira Kurisaki (548385), Yohei Ishigaki (548375), Kei Enomoto (548372), Yoshiro Nakajima (548380), Hitomi Takada (548383), Keigoh Ohnishi (548379), Shinji Komazaki (118718), Kaoru Kato (548381), Norio Yamakawa (186500), Yuko Kokubu (548378), Megumi Kowno (548369), Hisako Ishimine (548371), Makoto Asashima (127940), Taka-aki K. Noguchi (548377), Atsushi Intoh (548382), Yasuhiro Seki (548373)   +19 more
core   +1 more source

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin‐2 dephosphorylation and impairing mitochondrial quality control

Clinical and Translational Medicine
Background The induction of mitochondrial quality control (MQC) mechanisms is essential for the re‐establishment of mitochondrial homeostasis and cellular bioenergetics during periods of stress.
Jun Tao, Junxiong Qiu, Junmeng Zheng, Ruibing Li, Xing Chang, Qingyong He   +5 more
doaj   +1 more source

Mitochondria‐Related Pathogenic Genes in Paediatric Asthma: A Multi‐Omics Mendelian Randomization Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Mitochondrial dysfunction is implicated in asthma pathogenesis, but causal roles of mitochondrial‐related genes in paediatric asthma remain unclear. We performed a multi‐omics Mendelian randomization study integrating GWAS data from paediatric asthma cohorts with blood‐based methylation quantitative trait loci (mQTLs), expression QTLs (eQTLs ...
Biyu Zhang, Yaqin Li, Bo Ding, Xiaoyan Li, Yanming Lu   +4 more
wiley   +1 more source

Inhibition of insulin/IGF‐1 receptor signaling protects from mitochondria‐mediated kidney failure

EMBO Molecular Medicine, 2015
Mitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit prohibitin‐2 (
Christina Ising, Sybille Koehler, Sebastian Brähler, Carsten Merkwirth, Martin Höhne, Olivier R Baris, Henning Hagmann, Martin Kann, Francesca Fabretti, Claudia Dafinger, Wilhelm Bloch, Bernhard Schermer, Andreas Linkermann, Jens C Brüning, Christine E Kurschat, Roman‐Ulrich Müller, Rudolf J Wiesner, Thomas Langer, Thomas Benzing, Paul Thomas Brinkkoetter   +19 more
doaj   +1 more source

Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major

Parasites & Vectors, 2018
Background Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. Prohibitins (PHBs) are highly conserved proteins belonging to the stomatin-prohibitin
Teresa Cruz-Bustos, Ana Karina Ibarrola-Vannucci, Isabel Díaz-Lozano, José Luis Ramírez, A. Osuna   +4 more
doaj   +1 more source

Recent advances in pancreatic β‐cell dysfunction in type 2 diabetes mellitus: Intracellular stress and dedifferentiation

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1254-1256, August 2026.
Nozomi Kido, Shun‐ichiro Asahara
wiley   +1 more source

Identification of PHB2 as a Potential Biomarker of Luminal A Breast Cancer Cells Using a Cell-Specific Aptamer

, 2022
Precise diagnosis of breast cancer molecular subtypes remains a great challenge in clinics. The present molecular biomarkers are not specific enough to classify breast cancer subtypes precisely, which requests for more accurate and specific molecular ...
Yan Deng (159032), Nongyue He (1591204), Mei Liu (41760), Zhifei Wang (1622731), Song Li (65582)   +4 more
core   +1 more source