Results 71 to 80 of about 583 (139)

Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy

Clinical Genetics, Volume 110, Issue 2, Page 165-171, August 2026.
A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Marija Volk, Aleš Maver, Martina Jarc Vidmar, Nuša Trošt, Tanja Višnjar, Ana Fakin, Lea Kovač, Maja Šuštar Habjan, Lucija Malinar, Sanja Petrović Pajić, Urška Dragin Jerman, Rok Romih, Marko Hawlina, Borut Peterlin   +13 more
wiley   +1 more source

Prx1/PHB2 axis mediates mitophagy in oral leukoplakia cellular senescence

Pathology - Research and Practice
Oral leukoplakia (OLK) is the most common oral potentially malignant disorder (OPMD), which can be malignantly transformed into oral squamous cell carcinoma (OSCC). Peroxiredoxin1(Prx1) has been predicted to bind to Prohibitin2 (PHB2), which confers to affect OLK progression; however, the mechanism of Prx1/PHB2 mediated mitophagy involved in OLK ...
Yunping, Lu, Lingyu, Li, Jing, Li, Min, Wang, Jing, Yang, Min, Zhang, Qingsong, Jiang, Xiaofei, Tang   +7 more
openaire   +2 more sources

PHB2 SF-12 Osteoarthritis-Specific Health Index: Development And Validation

Value in Health, 1998
OBJECTIVE:To develop and validate SF-12 osteoarthritis-specific health index (SF-12 OASHI). METHODS:Patient data on SF-12 and six osteoarthritis (OP) clinical variables (physician and patient global assessments, pain intensity, knee pain on weight bearing and motion, time to walk 50 feet) at baseline and week, 6, from two placebo-controlled ...
Gandhi, SK, Salmon, JW, Zhao, SZ, Lambert, BL, Gore, P, Conrad, K   +5 more
openaire   +1 more source

Early brain‐penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1‐related Aicardi‐Goutières syndrome

Clinical &Translational Immunology, Volume 15, Issue 7, 2026.
Abstract Objectives Aicardi‐Goutières syndrome (AGS) is a genetic interferonopathy resulting from defects in nucleic acid metabolism and subsequent enhanced type I interferon signalling. We report how an expedited genomic diagnosis in conjunction with natural history data can enable a long‐term brain‐penetrant anti‐inflammatory regimen to optimise ...
Russell C Dale, Jessica Hayes, Velda X Han, Ruwani Dissanayake, Xianzhong Lau, Michelle Farrar, Brian Gloss, Markus Hofer, Esther Tantsis, Michelle Lorentzos, Safiyyah Abbas, Yanick J Crow, Shekeeb Mohammad, Shrujna Patel   +13 more
wiley   +1 more source

Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells. [PDF]

PLoS ONE, 2012
Increase in mitochondrial biogenesis has been shown to accompany brown and white adipose cell differentiation. Prohibitins (PHBs), comprised of two evolutionarily conserved proteins, prohibitin-1 (PHB1) and prohibitin-2 (PHB2), are present in a high ...
Dong Liu, Yiming Lin, Ting Kang, Bo Huang, Wei Xu, Minerva Garcia-Barrio, Moshood Olatinwo, Roland Matthews, Y Eugene Chen, Winston E Thompson   +9 more
doaj   +1 more source

A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1‐Driven Raf‐ERK Pathway Activation Promotes Cardiomyocyte Mitosis

MedComm, Volume 7, Issue 5, May 2026.
SalB binds to the C‐terminal of PHB1/2 heterodimer, inducing a conformational change that enhances Raf‐ERK pathway activation via Akt‐mediated phosphorylation, thereby promoting cardiomyocyte mitosis. ABSTRACT Heart failure (HF) following myocardial infarction remains a leading cause of global morbidity and mortality, necessitating novel therapeutic ...
Ce Cao, Bo Ma, Jian Zhang, Lili Yang, Zixin Liu, Haoran Li, Jianshu Song, Keer Zhang, Lei Li, Jianhua Fu, Jianxun Liu   +10 more
wiley   +1 more source

ATP biosynthesis, ROS production, and mitochondrial membrane potential of PHB2-knockdown ES cells and PHB2-overexpressing ES cells.

, 2014
(A, B) ATP concentration (A) and ROS level (B) were measured with EBRTcH3 cells that express PHB2 shRNA under the control of a Tc promoter. The ES cells were cultured in either the absence or presence of Tet for 4 days.
Ying Ying Wang (548374), Pi-Chao Wang (548384), Kanako Watanabe-Susaki (548370), Naoto Ninomiya (548376), Akira Kurisaki (548385), Yohei Ishigaki (548375), Kei Enomoto (548372), Yoshiro Nakajima (548380), Hitomi Takada (548383), Keigoh Ohnishi (548379), Shinji Komazaki (118718), Kaoru Kato (548381), Norio Yamakawa (186500), Yuko Kokubu (548378), Megumi Kowno (548369), Hisako Ishimine (548371), Makoto Asashima (127940), Taka-aki K. Noguchi (548377), Atsushi Intoh (548382), Yasuhiro Seki (548373)   +19 more
core   +1 more source

LINC00478-derived novel cytoplasmic lncRNA LacRNA stabilizes PHB2 and suppresses breast cancer metastasis via repressing MYC targets

Journal of Translational Medicine, 2023
Background Metastasis is the predominant cause of mortality in patients with breast cancer. Long noncoding RNAs (lncRNAs) have been shown to drive important phenotypes in tumors, including invasion and metastasis.
Rong Guo, Yonghui Su, Qi Zhang, Bingqiu Xiu, Sheng Huang, Weiru Chi, Liyi Zhang, Lun Li, Jianjing Hou, Jia Wang, Jiajian Chen, Yayun Chi, Jingyan Xue, Jiong Wu   +13 more
doaj   +1 more source

Multi‐Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre‐Frail Older Men by Losartan

Aging Cell, Volume 25, Issue 5, May 2026.
Losartan partially reversed serum metabolomic aging signatures in both aged mice and pre‐frail older men, and this effect required functional angiotensin II receptors in mice. Cross‐species analyses suggest aging shifts circulating metabolites in opposite directions in mice versus humans, particularly among lipids, with losartan partially normalizing ...
Michael R. Bene, Cissy Zhang, Reyhan Westbrook, Mariann Gabrawy, Ruth Marx, Yuqiong Wu, Mohammed Khadeer, Ceereena Ubaida‐Mohien, Luigi Ferrucci, Ruin Moaddel, Anne Le, Jeremy D. Walston, Jessica L. Lee, Peter M. Abadir   +13 more
wiley   +1 more source

PHB2 localized in mitochondria inhibits neuronal differentiation of ES cells.

, 2014
(A–C) Ectopic expression of PHB2WT but not PHB2AAAA inhibits neuronal differentiation. ES cells expressing PHB2-GFP were differentiated into neuronal cells as described in Fig. 4E.
Ying Ying Wang (548374), Pi-Chao Wang (548384), Kanako Watanabe-Susaki (548370), Naoto Ninomiya (548376), Akira Kurisaki (548385), Yohei Ishigaki (548375), Kei Enomoto (548372), Yoshiro Nakajima (548380), Hitomi Takada (548383), Keigoh Ohnishi (548379), Shinji Komazaki (118718), Kaoru Kato (548381), Norio Yamakawa (186500), Yuko Kokubu (548378), Megumi Kowno (548369), Hisako Ishimine (548371), Makoto Asashima (127940), Taka-aki K. Noguchi (548377), Atsushi Intoh (548382), Yasuhiro Seki (548373)   +19 more
core   +1 more source