Results 71 to 80 of about 2,921 (152)

International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease

Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.
As an orphan disease, where treatment is not curative and diagnosis is often slow, VSCM represents a serious health and social problem requiring research efforts in several directions. ABSTRACT Background Visceral myopathy (VSCM) is an ultra‐rare life‐threatening condition characterized by severe impairment of gastrointestinal (GI), genitourinary, and ...
Pascal de Santa Barbara, Isabella Ceccherini, Robert O. Heuckeroth, Carlo Di Lorenzo, Maria M. Alves, Arthur Beyder, Osvaldo Borrelli, Ludovica Cacopardo, Rachel Ceron, Jihong Chen, Federica Chiappori, Antonio Contessa, Roberto De Giorgio, Antonella Diamanti, Maria Grazia Faticato, Sandrine Faure, Sohaib K. Hashmi, Jan D. Huizinga, Raj P. Kapur, Cecile Lambe, Laurence Lancon, Ryan McManigal, Hayat Mousa, Alessandro Palmitelli, Victor Perreaux, Alessio Pini Prato, Michela Pitto, Elisa Proietti, John Rendu, Anna Rybak, Kenton M. Sanders, Sabah Sardar, Vincenzo Stanghellini, Renato Tambucci, Nikhil Thapar, Pieter Vanden Berghe, Massimo Vassalli, Qianqian Wang, Michael Wangler, Sharon Wolfson, Almira Zada, Jiliang Zhou, Federica Viti   +42 more
wiley   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, Volume 13, Issue 14, 9 March 2026.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

Recent advances in pancreatic β‐cell dysfunction in type 2 diabetes mellitus: Intracellular stress and dedifferentiation

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1254-1256, August 2026.
Nozomi Kido, Shun‐ichiro Asahara
wiley   +1 more source

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

Advanced Science, Volume 13, Issue 14, 9 March 2026.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao, Yanbin Li, Shengqi Zhang, Yilin He, Zhiqi Liu, Juan Wang, Jingmin Hua, Jinyu Chen, Junru Zhong, Huan Zhong, Yiji Xia, Yong Cui, Liwen Jiang   +12 more
wiley   +1 more source

Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin‐2 dephosphorylation and impairing mitochondrial quality control

Clinical and Translational Medicine
Background The induction of mitochondrial quality control (MQC) mechanisms is essential for the re‐establishment of mitochondrial homeostasis and cellular bioenergetics during periods of stress.
Jun Tao, Junxiong Qiu, Junmeng Zheng, Ruibing Li, Xing Chang, Qingyong He   +5 more
doaj   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

Inhibition of insulin/IGF‐1 receptor signaling protects from mitochondria‐mediated kidney failure

EMBO Molecular Medicine, 2015
Mitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit prohibitin‐2 (
Christina Ising, Sybille Koehler, Sebastian Brähler, Carsten Merkwirth, Martin Höhne, Olivier R Baris, Henning Hagmann, Martin Kann, Francesca Fabretti, Claudia Dafinger, Wilhelm Bloch, Bernhard Schermer, Andreas Linkermann, Jens C Brüning, Christine E Kurschat, Roman‐Ulrich Müller, Rudolf J Wiesner, Thomas Langer, Thomas Benzing, Paul Thomas Brinkkoetter   +19 more
doaj   +1 more source

Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major

Parasites & Vectors, 2018
Background Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. Prohibitins (PHBs) are highly conserved proteins belonging to the stomatin-prohibitin
Teresa Cruz-Bustos, Ana Karina Ibarrola-Vannucci, Isabel Díaz-Lozano, José Luis Ramírez, A. Osuna   +4 more
doaj   +1 more source

Targeting PHB2-mediated mitophagy alleviates nonesterified fatty acid-induced mitochondrial dysfunction in bovine mammary epithelial cells

Journal of Dairy Science
: Mitochondrial dysfunction has been reported to occur in the mammary gland of dairy cows suffering from ketosis. Prohibitin 2 (PHB2) plays a crucial role in regulating mitophagy, which clears impaired mitochondria to maintain normal mitochondrial ...
Guojin Li, Liguang Cao, Kai Liu, Yifei Dong, Zifeng Yang, Jianchun Luo, Wenrui Gao, Lin Lei, Yuxiang Song, Xiliang Du, Xinwei Li, Wenwen Gao, Guowen Liu   +12 more
doaj   +1 more source

Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects

Journal of Experimental & Clinical Cancer Research, 2019
Background Diffuse large B-cell lymphomas (DLBCLs) are aggressive lymphomas accounting for approximately a third of non-Hodgkin lymphomas. Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are scaffold proteins that promote mitochondria homeostasis and ...
Hafidha Bentayeb, Marine Aitamer, Barbara Petit, Lydie Dubanet, Sabria Elderwish, Laurent Désaubry, Armand de Gramont, Eric Raymond, Agnès Olivrie, Julie Abraham, Marie-Odile Jauberteau, Danielle Troutaud   +11 more
doaj   +1 more source