Results 91 to 100 of about 583 (139)

PHB2 inhibits the differentiation of ES cells into neuronal cells and endodermal cells but not into cardiomyocytes.

, 2014
(A, C, E) Effect of ectopic expression of PHB2 on the differentiation of mouse ES cells into cardiomyocytes (A), endoderm cells (C), or neuronal cells (E). EBRTcH3 cells were differentiated in the absence of Tc.
Ying Ying Wang (548374), Pi-Chao Wang (548384), Kanako Watanabe-Susaki (548370), Naoto Ninomiya (548376), Akira Kurisaki (548385), Yohei Ishigaki (548375), Kei Enomoto (548372), Yoshiro Nakajima (548380), Hitomi Takada (548383), Keigoh Ohnishi (548379), Shinji Komazaki (118718), Kaoru Kato (548381), Norio Yamakawa (186500), Yuko Kokubu (548378), Megumi Kowno (548369), Hisako Ishimine (548371), Makoto Asashima (127940), Taka-aki K. Noguchi (548377), Atsushi Intoh (548382), Yasuhiro Seki (548373)   +19 more
core   +1 more source

Targeting PHB2-mediated mitophagy alleviates nonesterified fatty acid-induced mitochondrial dysfunction in bovine mammary epithelial cells

Journal of Dairy Science
: Mitochondrial dysfunction has been reported to occur in the mammary gland of dairy cows suffering from ketosis. Prohibitin 2 (PHB2) plays a crucial role in regulating mitophagy, which clears impaired mitochondria to maintain normal mitochondrial ...
Guojin Li, Liguang Cao, Kai Liu, Yifei Dong, Zifeng Yang, Jianchun Luo, Wenrui Gao, Lin Lei, Yuxiang Song, Xiliang Du, Xinwei Li, Wenwen Gao, Guowen Liu   +12 more
doaj   +1 more source

Characterization of PHB, PHB2 and MYC as novel MTOR interactors

, 2021
MTOR, the mechanistic target of rapamycin, is a master regulator of cellular processes like metabolism, growth and proliferation. As such, it physically and functionally interacts with a wide range of other biomolecules to sense metabolic cues and affect
Schöpf, Philemon van Dao
core   +1 more source

Corosolic acid attenuates cardiac ischemia/reperfusion injury through the PHB2/PINK1/parkin/mitophagy pathway

iScience
Summary: Despite advances in treatment, myocardial infarction remains the leading cause of heart failure and death worldwide, and the restoration of coronary blood flow can also cause heart damage.
Jun Zhang, Yongjian Zhao, Lin Yan, Mingyue Tan, Yifeng Jin, Yunfei Yin, Lianhua Han, Xiao Ma, Yimin Li, Tianke Yang, Tingbo Jiang, Hongxia Li   +11 more
doaj   +1 more source

Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects

Journal of Experimental & Clinical Cancer Research, 2019
Background Diffuse large B-cell lymphomas (DLBCLs) are aggressive lymphomas accounting for approximately a third of non-Hodgkin lymphomas. Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are scaffold proteins that promote mitochondria homeostasis and ...
Hafidha Bentayeb, Marine Aitamer, Barbara Petit, Lydie Dubanet, Sabria Elderwish, Laurent Désaubry, Armand de Gramont, Eric Raymond, Agnès Olivrie, Julie Abraham, Marie-Odile Jauberteau, Danielle Troutaud   +11 more
doaj   +1 more source

PHB2 forms a mitochondrial calcium channel that drives Parkinson’s disease

Abstract Dysregulated mitochondrial Ca2+ influx is a unifying driver of neurodegeneration, compromising neuronal bioenergetics and survival. In Parkinson’s disease (PD), impaired mitochondrial Ca2+ uptake is a decisive trigger for dopaminergic (DA) neuron loss, yet the molecular identity of the responsible channel has remained ...
Zhou, Shu, Li, Yunyan, Fang, Yang, Yang, Jing, Liu, Yong, Wang, Yizhuo, Bai, Dongshuai, Gao, Yongxiang, Jiao, Ziying, Tang, Hengfang, Ji, Xinmiao, Song, Linlin, Richter, Christian, Mao, Wenping, Law, Betty, Schwalbe, Harald, Wang, Kai, Zhang, Xin, Shen, Bing, Wang, Junfeng   +19 more
openaire   +1 more source

Prohibitins: emerging host targets of bacteria and viruses at the plasma membrane, mitochondria, and cytoplasm

Microbial Cell
Ubiquitously expressed Prohibitin-1 (PHB1) and Prohibitin-2 (PHB2) serve pleiotropic functions in cellular processes, including signal transduction, mitochondrial metabolism and dynamics, and lipid raft formation. Located in phospholipid-rich subcellular
Grecia O. Rivera-Palomino, Arianne L. Theiss   +1 more
doaj   +1 more source

PHB1 and PHB2 positively regulate IFN-β production by targeting MAVS in ducks

Poultry Science
PHB1 and PHB2, two subunits of the mitochondrial prohibitin complex, are critical regulators of antiviral innate immunity. Ducks, as natural reservoirs for RNA viruses, exhibit unique antiviral mechanisms. RIG-I is a key receptor for recognizing RNA viruses in ducks.
Jinlu Liu, Shuwen Luo, Guoyao Wang, Xuming Hu, Guohong Chen, Qi Xu   +5 more
openaire   +2 more sources

Prohibitin 2 orchestrates long noncoding RNA and gene transcription to accelerate tumorigenesis

Nature Communications
The spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding genes contributes to malignancy development in various tumors. However, precise coordinated mechanisms underlying this phenomenon in tumorigenesis remains incompletely
Tianyi Ding, Haowen Xu, Xiaoyu Zhang, Fan Yang, Jixing Zhang, Yibing Shi, Yiran Bai, Jiaqi Yang, Chaoqun Chen, Chengbo Zhu, He Zhang   +10 more
doaj   +1 more source

PHB2 acts as a braker of progressive pulmonary fibrosis via intervention of DDR2-elicited signaling

Acta Biochimica et Biophysica Sinica
Idiopathic pulmonary fibrosis (IPF) is a fatal disease whose pathogenic mechanisms remain incompletely understood. Transforming growth factor-beta (TGF-β) is widely regarded as a central driver of fibrosis, orchestrating sustained fibroblast activation and pathological tissue scarring.
Penghui, Yang, Jinjun, Jiang, Jiani, Liu, Bing, Su, Xiaohua, Wang, Zhenli, Fu, Ying, He, Jing, Han, Chunrong, Ju, Yinuo, Wang, Xinpeng, Lu, Xiaomin, Peng, Hang, Yin, Junqi, Li, Dandan, Wang, Jianping, Liu, Yunxin, Lai, Jin, Su   +17 more
openaire   +2 more sources