Results 111 to 120 of about 583 (139)

Phb1:Phb2 heterodimers in the mitochondria—beyond functional interdependence [PDF]

Journal of Biological Chemistry, 2019
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Complement protein C1q induces endothelial apoptosis through C1qBP regulation of mitochondrial function in lung endothelial cells in systemic sclerosis

Molecular Medicine
Background Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and fibrosis, with pulmonary complications as the leading cause of mortality.
Zixi Yi, Kexin Liu, Mohammed Shabin
doaj   +1 more source

IGFBP6 orchestrates antiinfective immune collapse in murine sepsis via prohibitin-2–mediated immunosuppression

The Journal of Clinical Investigation
The persistent challenge of sepsis-related mortality underscores the necessity for deeper insights. Our multicenter, cross-age cohort study identified insulin-like growth factor binding protein 6 (IGFBP6) as a critical regulator in sepsis diagnosis ...
Kai Chen, Ying Hu, Xiaoyan Yu, Hong Tang, Yanting Ruan, Yue Li, Xun Gao, Qing Zhao, Hong Wang, Xuemei Zhang, David Paul Molloy, Yibing Yin, Dapeng Chen, Zhixin Song   +13 more
doaj   +1 more source

Prohibitin 2/PHB2 in Parkin-mediated mitophagy: a potential therapeutic target for mitochondrial diseases [PDF]

Acta Biochimica et Biophysica Sinica, 2017
Lu, He, Hong, Zhou, Hong, Liu, Hongtao, Qu   +3 more
openaire   +2 more sources

Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells

Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells
The acquisition of endocrine resistance is a common obstacle in endocrine therapy of patients with oestrogen receptor-α (ERα)-positive breast tumours. We previously demonstrated that the BIG3–PHB2 complex has a crucial role in the modulation of oestrogen/ERα signalling in breast cancer cells.
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LECT2-PHB2 axis: a new mechanistic insight and therapeutic opportunity in alcohol-associated hepatitis

Gut
Hui Li, Meiyi Song, Phillip B Hylemon, Huiping Zhou   +3 more
openaire   +2 more sources

Lamprey PHB2 maintains mitochondrial stability by tanslocation to the mitochondria under oxidative stress

Fish and Shellfish Immunology, 2020
Before we have reported lamprey PHB2 could enhance the cellular oxidative-stressed tolerance, here the aim was to explore its mechanisms. We used flow cytometry analysis to identify a Lampetra morii homologue of PHB2 (Lm-PHB2) that could significantly decrease the levels of ROS generation in HEK293T cells. According to confocal microscopy observations,
Qingwei Li, Tiesong Li
exaly   +3 more sources

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PHB2 interacts with RNF2 and represses CP2c-stimulated transcription

Molecular and Cellular Biochemistry, 2008
RNF2, a polycomb group protein, is an important component of PRC complex regulating transcriptional activity. Recently, several RNF2 interacting proteins have been identified. Thus, RNF2 might have multiple activities, depending on its interacting partner proteins.
Hyangshuk Rhim, Hyo-Jung Choo, Seongman Kang   +2 more
exaly   +3 more sources

PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing

Circulation Research, 2022
Background: Phenotypic transition of vascular smooth muscle cells (VSMCs) accounts for the pathogenesis of a variety of vascular diseases during the early stage. Recent studies indicate the metabolic reprogramming may be involved in VSMC phenotypic transition.
Yiting Jia, Chenfeng Mao, Zihan Ma, Jiaqi Huang, Wenqiang Li, Xiaolong Ma, Siting Zhang, Meihong Li, Fang Yu, Yingying Sun, Jingzhou Chen, Juan Feng, Yuan Zhou, Qingbo Xu, Ling Zhao, Yi Fu, Wei Kong   +16 more
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Study on the Role of Mitophagy Receptor PHB2 in Doubly Uniparental Inheritance of Hyriopsis cumingii

Marine Biotechnology, 2023
In bivalves, the heterogeneity of mitochondrial DNA and its unique mode of transmission have been the focus of attention, which is called doubly uniparental inheritance (DUI). Prohibitin-2 (phb2) is a mitochondrial inner membrane protein that is a key mitophagy receptor for parental mitochondrial removal.
Guiling Wang, Zhiyi Bai, Jiale Li
exaly   +3 more sources