Results 121 to 130 of about 583 (139)

Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy

Acta Pharmacologica Sinica, 2022
Heart aging is characterized by left ventricular hypertrophy and diastolic dysfunction, which in turn induces a variety of cardiovascular diseases. There is still no therapeutic drug to ameliorate cardiac abnormities in heart aging. In this study we investigated the protective effects of berberine (BBR) and its derivative tetrahydroberberrubine (THBru)
Lei, Wang, Xue-Qing, Tang, Yang, Shi, Hui-Min, Li, Zi-Yu, Meng, Hui, Chen, Xiao-Han, Li, Yong-Chao, Chen, Heng, Liu, Yang, Hong, Heng-Hui, Xu, Ling, Liu, Limin, Zhao, Wei-Na, Han, Xin, Liu, Yong, Zhang   +15 more
openaire   +2 more sources

The expression of PHB2 in the cochlea: Possible relation to age‐related hearing loss

Cell Biology International, 2021
AbstractAge‐related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly, but its mechanism remains unclear. Scaffold protein prohibitin 2 (PHB2) has been widely involved in aging and neurodegeneration. However, the role of PHB2 in ARHL is undeciphered to date.
Xiaoyu Yu, Ming Guan, Haiqiong Shang, Yaoshu Teng, Yueqiu Gao, Bin Wang, Zhiqi Ma, Xiaolin Cao, Yong Li   +8 more
openaire   +2 more sources

ASURA (PHB2) Interacts with Scc1 through Chromatin

Cytogenetic and Genome Research, 2013
Sister chromatid cohesion mediated by the cohesin complex is essential for faithful chromosome segregation. Previously we reported that PHB2 (prohibitin2/ASURA), a multifunctional protein, has a role in sister chromatid cohesion. Nevertheless, how ASURA is involved in sister chromatid cohesion still remains unclear.
I, Equilibrina, S, Matsunaga, A, Morimoto, T, Hashimoto, S, Uchiyama, K, Fukui   +5 more
openaire   +2 more sources

Elucidation of the structural dynamics of mutations in PHB2 protein associated with growth suppression and cancer progression

Gene
Prohibitin is a multifunctional protein that plays an important role in numerous cellular processes. Membrane-associated mitochondrial prohibitin complex is made up of two subunits, PHB1 and PHB2 which are ubiquitously expressed and analogous to each other.
Sujay Ray, Alankar Roy
exaly   +3 more sources

PHB2 inhibits WSSV replication by promoting the nuclear translocation of STAT

Fish & Shellfish Immunology
Prohibitins (PHBs) are ubiquitously expressed conserved proteins in eukaryotes that are associated with apoptosis, cancer formation, aging, stress responses and cell proliferation. However, the function of the PHBs in immune regulation has largely not been determined.
Jia-Yu, Si, Lian-Jie, Wu, Feng-Lin, Xu, Xiao-Tong, Cao, Jiang-Feng, Lan   +4 more
openaire   +2 more sources

PHB2 binds to ERβ to induce the autophagy of porcine ovarian granulosa cells through mTOR phosphorylation

Theriogenology, 2023
Autophagy of ovarian granulosa cells is one of the reasons which results in follicular atresia. PHB2 regulates many fundamental biological processes and is pivotal in the mitophagy of cells; nevertheless, the autophagy in the porcine ovary and how PHB2 regulates the follicular cells are unknown.
Guangyu Liu, Yifan Wang, Yuxin Zheng, Jing Lv, Yuanyou Li, Ning Liu, Huimin Gao, Haohan Ran, Hong Tang, Zhongliang Jiang   +9 more
openaire   +2 more sources

Expression pattern of phb2 and its potential function in spermatogenesis of scallop (Chlamys farreri)

Journal of Ocean University of China, 2015
Prohibitin (PHB) participates in several biological processes including apoptosis, transcription regulation and suppression of cell proliferation in mammals. In this study, we cloned the full-length cDNA of prohibitin 2 (Cf-phb2) from the testis of scallop (Chlamys farreri).
Tiantian Han, Xiaoshi Ma
exaly   +2 more sources

PHB2 Governs Metabolism and Phenotypic Switching of VSMCs in Vascular Remodeling

Circulation Research, 2022
Kathy O. Lui, Yu Huang
openaire   +2 more sources

Dihydroartemisinin synergistically enhances the cytotoxic effects of oxaliplatin in colon cancer by targeting the PHB2‐RCHY1 mediated signaling pathway

Molecular Carcinogenesis, 2023
Chunyan Liu
exaly  

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

Autophagy, 2020
Mingliang Tang, Laurent Desaubry, Hussein Abou-Hamdan   +2 more
exaly