Results 131 to 140 of about 2,921 (152)

Expression pattern of phb2 and its potential function in spermatogenesis of scallop (Chlamys farreri)

Journal of Ocean University of China, 2015
Prohibitin (PHB) participates in several biological processes including apoptosis, transcription regulation and suppression of cell proliferation in mammals. In this study, we cloned the full-length cDNA of prohibitin 2 (Cf-phb2) from the testis of scallop (Chlamys farreri).
Shaoshuai Liang, Tiantian Han, Beibei Gao   +2 more
exaly   +2 more sources

PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing

Circulation Research, 2022
Background: Phenotypic transition of vascular smooth muscle cells (VSMCs) accounts for the pathogenesis of a variety of vascular diseases during the early stage. Recent studies indicate the metabolic reprogramming may be involved in VSMC phenotypic transition.
Yiting Jia, Chenfeng Mao, Zihan Ma, Jiaqi Huang, Wenqiang Li, Xiaolong Ma, Siting Zhang, Meihong Li, Fang Yu, Yingying Sun, Jingzhou Chen, Juan Feng, Yuan Zhou, Qingbo Xu, Ling Zhao, Yi Fu, Wei Kong   +16 more
openaire   +2 more sources

The expression of PHB2 in the cochlea: Possible relation to age‐related hearing loss

Cell Biology International, 2021
AbstractAge‐related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly, but its mechanism remains unclear. Scaffold protein prohibitin 2 (PHB2) has been widely involved in aging and neurodegeneration. However, the role of PHB2 in ARHL is undeciphered to date.
Xiaoyu Yu, Ming Guan, Haiqiong Shang, Yaoshu Teng, Yueqiu Gao, Bin Wang, Zhiqi Ma, Xiaolin Cao, Yong Li   +8 more
openaire   +2 more sources

Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy

Acta Pharmacologica Sinica, 2022
Heart aging is characterized by left ventricular hypertrophy and diastolic dysfunction, which in turn induces a variety of cardiovascular diseases. There is still no therapeutic drug to ameliorate cardiac abnormities in heart aging. In this study we investigated the protective effects of berberine (BBR) and its derivative tetrahydroberberrubine (THBru)
Lei, Wang, Xue-Qing, Tang, Yang, Shi, Hui-Min, Li, Zi-Yu, Meng, Hui, Chen, Xiao-Han, Li, Yong-Chao, Chen, Heng, Liu, Yang, Hong, Heng-Hui, Xu, Ling, Liu, Limin, Zhao, Wei-Na, Han, Xin, Liu, Yong, Zhang   +15 more
openaire   +2 more sources

Study on the Role of Mitophagy Receptor PHB2 in Doubly Uniparental Inheritance of Hyriopsis cumingii

Marine Biotechnology, 2023
In bivalves, the heterogeneity of mitochondrial DNA and its unique mode of transmission have been the focus of attention, which is called doubly uniparental inheritance (DUI). Prohibitin-2 (phb2) is a mitochondrial inner membrane protein that is a key mitophagy receptor for parental mitochondrial removal.
Yayu, Wang, Xiaoyue, Zhu, Yang, Gu, Zongyu, Liu, Yingrui, Mao, Xiaojun, Liu, Zhiyi, Bai, Guiling, Wang, Jiale, Li   +8 more
openaire   +2 more sources

ASURA (PHB2) Interacts with Scc1 through Chromatin

Cytogenetic and Genome Research, 2013
Sister chromatid cohesion mediated by the cohesin complex is essential for faithful chromosome segregation. Previously we reported that PHB2 (prohibitin2/ASURA), a multifunctional protein, has a role in sister chromatid cohesion. Nevertheless, how ASURA is involved in sister chromatid cohesion still remains unclear.
I, Equilibrina, S, Matsunaga, A, Morimoto, T, Hashimoto, S, Uchiyama, K, Fukui   +5 more
openaire   +2 more sources

PHB2 inhibits WSSV replication by promoting the nuclear translocation of STAT

Fish & Shellfish Immunology
Prohibitins (PHBs) are ubiquitously expressed conserved proteins in eukaryotes that are associated with apoptosis, cancer formation, aging, stress responses and cell proliferation. However, the function of the PHBs in immune regulation has largely not been determined.
Jia-Yu, Si, Lian-Jie, Wu, Feng-Lin, Xu, Xiao-Tong, Cao, Jiang-Feng, Lan   +4 more
openaire   +2 more sources

PHB2 binds to ERβ to induce the autophagy of porcine ovarian granulosa cells through mTOR phosphorylation

Theriogenology, 2023
Autophagy of ovarian granulosa cells is one of the reasons which results in follicular atresia. PHB2 regulates many fundamental biological processes and is pivotal in the mitophagy of cells; nevertheless, the autophagy in the porcine ovary and how PHB2 regulates the follicular cells are unknown.
Guangyu Liu, Yifan Wang, Yuxin Zheng, Jing Lv, Yuanyou Li, Ning Liu, Huimin Gao, Haohan Ran, Hong Tang, Zhongliang Jiang   +9 more
openaire   +2 more sources

PHB2 Governs Metabolism and Phenotypic Switching of VSMCs in Vascular Remodeling

Circulation Research, 2022
Kathy O. Lui, Yu Huang
openaire   +2 more sources

PHB2 Alleviates Neurotoxicity of Prion Peptide PrP106–126 via PINK1/Parkin-Dependent Mitophagy

International Journal of Molecular Sciences, 2023
Zheng Xiaohui
exaly