Results 101 to 110 of about 583 (139)

Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

Scientific Reports, 2017
Estradiol (E2) and the oestrogen receptor-alpha (ERα) signalling pathway play pivotal roles in the proliferative activity of breast cancer cells. Recent findings show that the brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-
Tetsuro Yoshimaru, Keisuke Aihara, Masato Komatsu, Yosuke Matsushita, Yasumasa Okazaki, Shinya Toyokuni, Junko Honda, Mitsunori Sasa, Yasuo Miyoshi, Akira Otaka, Toyomasa Katagiri   +10 more
doaj   +1 more source

Additional file 1 of PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer

Additional file 1: Supplementary Figure 1. SHIP2 directly interacts with PHB2. Supplementary Figure 2. PHB2 regulates the protein expression of SHIP2 through ubiquitination. Supplementary Figure 3.
Liang Xu (102656), Jiezhen Yang (17771334), Xinyue Wang (286629), Li Meng (136180), Wanying Xiang (17771331), Kaihong Ye (17771337), Xiao Hong Zhao (15151806), Lei Jin (120473), Xu Dong Zhang (13467952), Yan Ye (549400), Jing Gao (69330)   +10 more
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The mechanism of the E2-dependent nuclear translocation of PHB2 through KPNAs in breast cancer cells.

, 2015
The mechanism of the E2-dependent nuclear translocation of PHB2 through KPNAs in breast cancer cells.
Toyomasa Katagiri (25446), Taisuke Matsuo (664130), Yasuo Miyoshi (751320), Nam-Hee Kim (744919), Kenji Mizuguchi (45280), Tetsuro Yoshimaru (664133), Mitsunori Sasa (751321), Yi-An Chen (83967), Masato Komatsu (664132), Eiji Tanaka (111967)   +9 more
core   +1 more source

Tau hyperphosphorylation and filaments in Phb2^NKO mice.

, 2012
(A) Transmission electron microscopy analysis of hippocampal tissue from 14-week-old Phb2NKO mice revealed the presence of straight filamentous tubules in neuronal unmyelinated processes reminiscent of tau filaments. Scale bars: 1.5 µm (left panel); 1 µm
Anne Korwitz (122006), Sabine D. Jordan (122012), Michela Morbin (122009), Paola Martinelli (122001), Elena I. Rugarli (122017), Thomas Langer (122021), Hella S. Brönneke (102436), Carsten Merkwirth (121996)   +7 more
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Late-onset mtDNA loss and respiratory dysfunction in Phb2^NKO mice.

, 2012
(A) and (B) Oxygen consumption of mitochondria isolated from the hippocampus of (A) 12-week-old or (B) 18-week-old Phb2NKO and Phb2fl/fl control mice in the presence of specific substrates for individual respective respiratory chain complexes.
Anne Korwitz (122006), Sabine D. Jordan (122012), Michela Morbin (122009), Paola Martinelli (122001), Elena I. Rugarli (122017), Thomas Langer (122021), Hella S. Brönneke (102436), Carsten Merkwirth (121996)   +7 more
core   +1 more source

Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions [PDF]

, 2014
Xanthohumol (XN) is a natural anticancer compound that inhibits the proliferation of oestrogen receptor-α (ERα)-positive breast cancer cells. However, the precise mechanism of the antitumour effects of XN on oestrogen (E2)-dependent cell growth and ...
片桐, 豊雅, 80424729, Miyoshi, Yasuo, ヨシマル, テツロウ, Katagiri, Toyomasa, Tashiro, Etsu, Imoto, Masaya, 174774/profile-ja.html, Osada, Hiroyuki, Yoshimaru, Tetsuro, Komatsu, Masato, カタギリ, トヨマサ, 吉丸, 哲郎, 207229/profile-ja.html, 60291895, Sasa, Mitsunori, 316, 418, Honda, Junko   +18 more
core  

Development of capsaicin derivatives as prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction in cancer cells

Aurora kinase A/AURKA is a serine/threonine kinase overexpressed in a variety of solid and hematological malignancies. In the last decades, clinical trials aiming to counteract the overexpression of AURKA turned out to be largely unsuccessful. Meanwhile,
Bertolin, Giulia, Désaubry, Laurent, Pizza, Valentina, Djehal, Amel, Farin, Kimberley, Caron, Claire   +5 more
core   +1 more source

KPNA1, KPNA5, and KPNA6 induce E2-dependent nuclear translocation of PHB2.

, 2015
(A) Immunoblotting analysis was performed to evaluate the interactions between ERα and PHB2 in BIG3- and KPNA (KPNA1, KPNA5, and KPNA6)-depleted MCF-7 cells. MCF-7 cells were treated with siBIG3 and each siKPNA, followed by E2 ± ERAP for 24 h.
Toyomasa Katagiri (25446), Taisuke Matsuo (664130), Yasuo Miyoshi (751320), Nam-Hee Kim (744919), Kenji Mizuguchi (45280), Tetsuro Yoshimaru (664133), Mitsunori Sasa (751321), Yi-An Chen (83967), Masato Komatsu (664132), Eiji Tanaka (111967)   +9 more
core   +1 more source

High glucose- or AGE-induced oxidative stress inhibits hippocampal neuronal mitophagy through the Keap1–Nrf2–PHB2 pathway in diabetic encephalopathy

Scientific Reports
Diabetic encephalopathy (DE) is a severe complication of diabetes, but its pathogenesis remains unclear. This study aimed to investigate the roles and underlying mechanisms of high glucose (HG)- and advanced glycosylation end product (AGE)-induced ...
Shan Xu, Zhaoyu Gao, Lei Jiang, Jiazheng Li, Yushi Qin, Di Zhang, Pei Tian, Wanchang Wang, Nan Zhang, Rui Zhang, Shunjiang Xu   +10 more
doaj   +1 more source

GOLPH3 promotes glioma progression by enhancing PHB2-mediated autophagy.

American journal of cancer research
Due to the hypoxia and nutrient deficiency microenvironment, malignant glioma exhibits high autophagy activity and autophagy plays a significant role in the occurrence and development of glioma. However, the potential molecular mechanism of autophagy in glioma remains unknown. In this study, we demonstrated that Golgi phosphorylation protein 3 (GOLPH3),
Kai, Wang, Yanhua, Qi, Xu, Wang, Yushuai, Liu, Min, Zhao, Ding, Zhou, Yu, Zhang, Yan, Wang, Rutong, Yu, Xiuping, Zhou   +9 more
openaire   +1 more source