Results 21 to 30 of about 583 (139)

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +2 more sources

Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells

Communications Biology
Aurora kinase A/AURKA is a serine/threonine kinase frequently overexpressed in cancer. Recent discoveries pointed to subcellular pools of AURKA, including at mitochondria.
Amel Djehal, Claire Caron, Deborah Giordano, Valentina Pizza, Kimberley Farin, Angelo Facchiano, Laurent Désaubry, Giulia Bertolin   +7 more
doaj   +3 more sources

PHB2 ameliorates ferroptosis and aortic aneurysm/dissection through NEDD4L-dependent ubiquitination of NCOA4

Redox Biology
Background: Aortic aneurysm/dissection (AAD) is a catastrophic vascular emergency with limited therapeutic options and poorly understood molecular underpinnings.
Shengjun Xiong, Jie Lin, Ying An, Yuxin Du, Yiran E. Li, Zunhui Du, Rongjun Zou, Miyesaier Abudureyimu, Junbo Ge, Yingmei Zhang, Jun Ren   +10 more
doaj   +3 more sources

Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy

Redox Biology, 2022
Renal tubular epithelial cells (RTECs) are one of the most mitochondria-rich cell types, and are thus vulnerable to mitochondrial dysregulation, which is defined as a pivotal event in tubular damage in diabetic nephropathy (DN).
Lei Liu, Fang Bai, Hui Song, Rong Xiao, Yuzhen Wang, Huimin Yang, Xiaolei Ren, Shuangjie Li, Lifen Gao, Chunhong Ma, Xiangdong Yang, Xiaohong Liang   +11 more
doaj   +3 more sources

PHB2 interacts with LC3 and SQSTM1 is required for bile acids-induced mitophagy in cholestatic liver [PDF]

Cell Death & Disease, 2018
Mitophagy is a major pathway for clearance of injured mitochondria. However, whether mitophagy is involved in the cholestasis-induced damages of hepatic mitochondria remains unknown.
Yongtao Xiao, Ying Lu, Kejun Zhou, Wei Cai, Ying Zhou   +4 more
core   +3 more sources

Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection

Viruses, 2020
Enterovirus A71 (EV-A71) is a major pathogen that causes severe and fatal cases of hand-foot-and-mouth disease (HFMD). HFMD caused by EV-A71 seriously endangers children’s health.
Weitao Su, Shan Huang, Huimin Zhu, Bao Zhang, Xianbo Wu   +4 more
doaj   +2 more sources

Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells [PDF]

Nature Communications, 2013
The acquisition of endocrine resistance is a common obstacle in endocrine therapy of patients with oestrogen receptor-α (ERα)-positive breast tumours. We previously demonstrated that the BIG3–PHB2 complex has a crucial role in the modulation of oestrogen/
80424729, ヨシマル, テツロウ, Akiyama, Miki, 174774/profile-ja.html, Yoshimaru, Tetsuro, 吉丸, 哲郎, Miyano, Satoru, 207229/profile-ja.html, Imoto, Seiya, Nakamura, Yusuke, Murakami, Yoichi, Sasa, Mitsunori, 316, 418, Yamaguchi, Rui, Matsuo, Taisuke, Chen, Yi-An, 片桐, 豊雅, Katagiri, Toyomasa, Inoue, Tsuyoshi, Mizohata, Eiichi, Komatsu, Masato, カタギリ, トヨマサ, 60291895, Miyoshi, Yasuo, Mizuguchi, Kenji   +25 more
core   +4 more sources

PHB2 mitigates intervertebral disc degeneration by modulating mitophagy to inhibit necroptosis in nucleus pulposus cells

iScience
Summary: Intervertebral disc degeneration involves loss of nucleus pulposus (NP) cells driven by inflammatory and mitochondrial stress-related death pathways.
Zhenyu Zhu, Yongcheng Liang, Xiaowen Liu, Fanqi Kong, Kaiqiang Sun, Ximing Xu, Jiangang Shi   +6 more
doaj   +3 more sources

Src-mediated PHB2 phosphorylation disrupts mitochondrial cristae through cardiolipin dissociation in hepatocellular carcinoma

Redox Biology
Hepatocellular carcinoma (HCC) displays mitochondrial dysfunction characterized by disrupted redox homeostasis and cristae disorganization, yet the underlying molecular mechanisms are unclear.
Zhehua Shao, Xinnuo Yang, Binben Wang, Xuwen Wang, Duoduo Zhao, Bingchen Liu, Jinliang Nan   +6 more
doaj   +2 more sources

Mycobacterial protein PE_PGRS30 induces macrophage apoptosis through prohibitin 2 mitochondrial function interference

Frontiers in Microbiology, 2023
PE_PGRS30 belongs to the PE_PGRS protein family and is characterized by a conserved Pro-Glu (PE) domain and a typically polymorphic GC-rich sequence (PGRS) domain. PE_PGRS30 is a virulence factor of Mycobacterium tuberculosis that induces macrophage cell
Kazunori Matsumura, Satoshi Takaki, Teruo Kirikae   +2 more
doaj   +1 more source