Results 21 to 30 of about 2,921 (152)

Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy

Redox Biology, 2022
Renal tubular epithelial cells (RTECs) are one of the most mitochondria-rich cell types, and are thus vulnerable to mitochondrial dysregulation, which is defined as a pivotal event in tubular damage in diabetic nephropathy (DN).
Lei Liu, Fang Bai, Hui Song, Rong Xiao, Yuzhen Wang, Huimin Yang, Xiaolei Ren, Shuangjie Li, Lifen Gao, Chunhong Ma, Xiangdong Yang, Xiaohong Liang   +11 more
doaj   +3 more sources

PHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE–RAGE pathway

Open Life Sciences
Fibrosis is the primary cause of retinal detachment and visual decline. Here, we investigated the role of Prohibitin 2 (PHB2) in modulating fibrosis in ARPE-19 cells stimulated by transforming growth factor (TGF)-β2.
Chen Feng, Cai Xiaoxiao, Yu Ying
doaj   +3 more sources

A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1-Driven Raf-ERK Pathway Activation Promotes Cardiomyocyte Mitosis. [PDF]

MedComm (2020)
SalB binds to the C‐terminal of PHB1/2 heterodimer, inducing a conformational change that enhances Raf‐ERK pathway activation via Akt‐mediated phosphorylation, thereby promoting cardiomyocyte mitosis. ABSTRACT Heart failure (HF) following myocardial infarction remains a leading cause of global morbidity and mortality, necessitating novel therapeutic ...
Cao C, Ma B, Zhang J, Yang L, Liu Z, Li H, Song J, Zhang K, Li L, Fu J, Liu J.   +10 more
europepmc   +2 more sources

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2-Mediated Mitochondrial Stabilization. [PDF]

Adv Sci (Weinh)
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Xu Y, Sun Y, Zhou X, Song K, Yin C, Wang Z, Xie F, Li H.   +7 more
europepmc   +2 more sources

BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells. [PDF]

PLoS ONE, 2015
We recently reported that brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) binds Prohibitin 2 (PHB2) in cytoplasm, thereby causing a loss of function of the PHB2 tumor suppressor in the nuclei of breast cancer cells.
Nam-Hee Kim, Tetsuro Yoshimaru, Yi-An Chen, Taisuke Matsuo, Masato Komatsu, Yasuo Miyoshi, Eiji Tanaka, Mitsunori Sasa, Kenji Mizuguchi, Toyomasa Katagiri   +9 more
doaj   +1 more source

Mycobacterial protein PE_PGRS30 induces macrophage apoptosis through prohibitin 2 mitochondrial function interference

Frontiers in Microbiology, 2023
PE_PGRS30 belongs to the PE_PGRS protein family and is characterized by a conserved Pro-Glu (PE) domain and a typically polymorphic GC-rich sequence (PGRS) domain. PE_PGRS30 is a virulence factor of Mycobacterium tuberculosis that induces macrophage cell
Kazunori Matsumura, Satoshi Takaki, Teruo Kirikae   +2 more
doaj   +1 more source

PHB2 Protects Sister-Chromatid Cohesion in Mitosis [PDF]

Current Biology, 2007
Cohesion between sister chromatids is essential for proper chromosome segregation in mitosis. In vertebrate mitotic cells, most cohesin is removed from the chromosome arms [1-4], but centromeric cohesin is protected by shugoshin until the onset of anaphase [5].
Takata, Hideaki, Matsunaga, Sachihiro, Morimoto, Akihiro, Ma, Nan, Kurihara, Daisuke, Ono-Maniwa, Rika, Nakagawa, Masatoshi, Azuma, Takachika, Uchiyama, Susumu, Fukui, Kiichi   +9 more
openaire   +2 more sources

PHB2/prohibitin 2: An inner membrane mitophagy receptor [PDF]

Cell Research, 2017
Mitophagy, the selective autophagic elimination of mitochondria, is a conserved cellular process critical for maintaining normal cellular physiology, and defects in this process are associated with certain pathophysiologies. In a recently published paper, Wei et al. describe their discovery of a hitherto unexplored mechanism of marking mitochondria for
Vikramjit, Lahiri, Daniel J, Klionsky
openaire   +2 more sources

Non-classical ferroptosis inhibition by a small molecule targeting PHB2

Nature Communications, 2022
AbstractFerroptosis is a new type of programmed cell death characterized by iron-dependent lipid peroxidation. Ferroptosis inhibition is thought as a promising therapeutic strategy for a variety of diseases. Currently, a majority of known ferroptosis inhibitors belong to either antioxidants or iron-chelators. Here we report a new ferroptosis inhibitor,
Wei Yang, Bo Mu, Jing You, Chenyu Tian, Huachao Bin, Zhiqiang Xu, Liting Zhang, Ronggang Ma, Ming Wu, Guo Zhang, Chong Huang, Linli Li, Zhenhua Shao, Lunzhi Dai, Laurent Désaubry, Shengyong Yang   +15 more
openaire   +4 more sources

Mitochondria-Related Pathogenic Genes in Paediatric Asthma: A Multi-Omics Mendelian Randomization Study. [PDF]

J Cell Mol Med
ABSTRACT Mitochondrial dysfunction is implicated in asthma pathogenesis, but causal roles of mitochondrial‐related genes in paediatric asthma remain unclear. We performed a multi‐omics Mendelian randomization study integrating GWAS data from paediatric asthma cohorts with blood‐based methylation quantitative trait loci (mQTLs), expression QTLs (eQTLs ...
Zhang B, Li Y, Ding B, Li X, Lu Y.
europepmc   +2 more sources