OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase
Cell ReportsSummary: Mitochondrial proteins are transported and sorted to the matrix or inner mitochondrial membrane by the presequence translocase TIM23. In yeast, this essential and highly conserved machinery is composed of the core subunits Tim23 and Tim17.
Praveenraj Elancheliyan +10 more
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In-situ architecture of the human prohibitin complex [PDF]
Nature Cell BiologyAbstract Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation and many others 1, 2 . The human prohibitins PHB1 and
Felix Lange +7 more
europepmc +9 more sources
Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases [PDF]
Frontiers in Genetics, 2021 A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins
Misa Belser +2 more
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Prohibitins are required for cancer cell proliferation and adhesion. [PDF]
PLoS ONE, 2010 Prohibitin 1 (PHB1) is a highly conserved protein that together with its homologue prohibitin 2 (PHB2) mainly localizes to the inner mitochondrial membrane.
Claudia Sievers +3 more
doaj +2 more sources
The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication. [PDF]
PLoS ONE, 2015 Apolipoprotein L9b (Apol9b) is an interferon-stimulated gene (ISG) that has antiviral activity and is weakly expressed in primary mouse neurons as compared to other cell types.
Marguerite Kreit +3 more
doaj +3 more sources
Mitochondrial prohibitin complex regulates fungal virulence via ATG24-assisted mitophagy
Communications Biology, 2022 Prohibitins recruit ChATG24 into the mitochondria to modulate mitophagy, thereby affecting the virulence of Colletotrichum higginsianum.
Yaqin Yan +9 more
doaj +2 more sources
Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins
iScience, 2023 Summary: 5′-Adenosine monophosphate-activated protein kinase (AMPK) is a potential therapeutic target for various medical conditions. We here identify a small-molecule compound (RX-375) that activates AMPK and inhibits fatty acid synthesis in cultured ...
Shuhei Kanagaki +16 more
doaj +2 more sources
Prohibitins and the functional compartmentalization of mitochondrial membranes [PDF]
Journal of Cell Science, 2009 Prohibitins constitute an evolutionarily conserved and ubiquitously expressed family of membrane proteins that are essential for cell proliferation and development in higher eukaryotes. Roles for prohibitins in cell signaling at the plasma membrane and in transcriptional regulation in the nucleus have been proposed, but pleiotropic defects associated ...
C. Osman, C. Merkwirth, T. Langer
openaire +5 more sources
Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance [PDF]
Microbiology SpectrumThe SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. In the yeast Candida albicans, stomatin-
Hyunjeong Kim +7 more
doaj +2 more sources
Prohibitions in the meta-inflammatory response: a review [PDF]
Frontiers in Molecular BiosciencesProhibitins are the central regulatory element of cellular homeostasis, especially by modulating the response at different levels: Nucleus, mitochondria and membranes.
Natalia Todosenko +5 more
doaj +2 more sources