Results 11 to 20 of about 1,545 (164)

Prohibitins in neurodegeneration and mitochondrial homeostasis

Frontiers in Aging, 2022
The incidence of age-related neurodegenerative disorders has risen with the increase of life expectancy. Unfortunately, the diagnosis of such disorders is in most cases only possible when the neurodegeneration status is already advanced, and symptoms are
Jesus Fernandez-Abascal, Jesus Fernandez-Abascal, Marta Artal-Sanz, Marta Artal-Sanz   +3 more
doaj   +5 more sources

Prohibitins in infection: potential therapeutic targets [PDF]

Future Microbiology
Prohibitins (PHBs) are members of a highly conserved family of proteins, including prohibitin1 and prohibitin2. These proteins are predominantly localized in mitochondria, the nucleus, and cell membranes, where they play critical roles in mitochondrial biogenesis, apoptosis, immune regulation, and other biological processes.
Chen N, Liu X, Wang L, Yu H, Liu F, Yuan M, Wang Q, Zhang T, Zhou X, Wang H, Ji Z, Shen H.   +11 more
exaly   +4 more sources

Prohibitins: emerging host targets of bacteria and viruses at the plasma membrane, mitochondria, and cytoplasm [PDF]

Microbial Cell
Ubiquitously expressed Prohibitin-1 (PHB1) and Prohibitin-2 (PHB2) serve pleiotropic functions in cellular processes, including signal transduction, mitochondrial metabolism and dynamics, and lipid raft formation. Located in phospholipid-rich subcellular
Grecia O. Rivera-Palomino, Arianne L. Theiss   +1 more
doaj   +2 more sources

OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase

Cell Reports
Summary: Mitochondrial proteins are transported and sorted to the matrix or inner mitochondrial membrane by the presequence translocase TIM23. In yeast, this essential and highly conserved machinery is composed of the core subunits Tim23 and Tim17.
Praveenraj Elancheliyan, Klaudia K. Maruszczak, Remigiusz Adam Serwa, Till Stephan, Ahmet Sadik Gulgec, Mayra A. Borrero-Landazabal, Sonia Ngati, Aleksandra Gosk, Stefan Jakobs, Michal Wasilewski, Agnieszka Chacinska   +10 more
doaj   +2 more sources

The function of prohibitins in mitochondria and the clinical potentials

Cancer Cell International, 2022
Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways.
Linda Oyang, Jian Li, Xianjie Jiang, Jinguan Lin, Longzheng Xia, Lixia Yang, Shiming Tan, Nayiyuan Wu, Yaqian Han, Yiqing Yang, Xia Luo, Jinyun Li, Qianjin Liao, Yingrui Shi, Yujuan Zhou   +14 more
doaj   +3 more sources

mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage [PDF]

Cell Communication and Signaling
Introduction Cardiac mitochondrial function is intricately regulated by various processes, ultimately impacting metabolic performance. Additionally, protein turnover is crucial for sustained metabolic homeostasis in cardiomyocytes.
Hugo E. Verdejo, Valentina Parra, Andrea del Campo, Cesar Vasquez-Trincado, Damian Gatica, Camila Lopez-Crisosto, Jovan Kuzmicic, Leslye Venegas-Zamora, Ursula Zuñiga-Cuevas, Mayarling F. Troncoso, Rodrigo Troncoso, Beverly A. Rothermel, Mario Chiong, E. Dale Abel, Sergio Lavandero   +14 more
doaj   +2 more sources

In situ architecture of the human prohibitin complex. [PDF]

Nat Cell Biol
Abstract Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation and many others 1, 2 . The human prohibitins PHB1 and
Lange F, Ratz M, Dohrke JN, Le Vasseur M, Wenzel D, Ilgen P, Riedel D, Jakobs S.   +7 more
europepmc   +7 more sources

The Role of Prohibitin-2 in Diseases

Frontiers in Bioscience-Landmark, 2023
Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis. Recently, there has been growing interest in the biological function of PHB2.
Fang Liu, You Zhang, Zhiyong Guo, An-Jing Ren   +3 more
openaire   +3 more sources

Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling

Antioxidants, 2023
Recent studies have shown that FMS-like receptor tyrosine kinase 3 (Flt3) has a beneficial effect on cardiac maladaptive remodeling. However, the role and mechanism of Flt3 in mitochondrial dynamic imbalance under cardiac stress remains poorly understood.
Kaina Zhang, Yeqing Zheng, Gaowa Bao, Wenzhuo Ma, Bing Han, Hongwen Shi, Zhenghang Zhao   +6 more
doaj   +1 more source

Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases

Frontiers in Genetics, 2021
A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins
Misa Belser, David W. Walker, David W. Walker   +2 more
doaj   +1 more source