Results 21 to 30 of about 299,635 (236)

Expression of activation-induced cytidine deaminase splicing variants in patients with ankylosing spondylitis

Autoimmunity, 2017
To investigate the expression patterns of activation-induced cytidine deaminase (AID) variants in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and examine their clinical implications, we isolated PBMCs from ...
Ji-Young Kim, Hee-Kyung Yoon, Seung Taek Song, Seok-Rae Park, Seung-Cheol Shim   +4 more
doaj   +1 more source

Association between serum bone biomarker levels and therapeutic response to abatacept in patients with rheumatoid arthritis (RA): a multicenter, prospective, and observational RA ultrasound cohort study in Japan

BMC Musculoskeletal Disorders, 2021
Background To evaluate the effect of treatment on serum bone biomarkers and explore whether serum bone biomarkers are associated with therapeutic response in rheumatoid arthritis (RA) patients treated with abatacept.
Shin-ya Kawashiri, Yushiro Endo, Ayako Nishino, Momoko Okamoto, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Remi Sumiyoshi, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Toshiyuki Aramaki, Yukitaka Ueki, Tamami Yoshitama, Nobutaka Eiraku, Naoki Matsuoka, Akitomo Okada, Keita Fujikawa, Hiroaki Hamada, Shuji Nagano, Yoshifumi Tada, Atsushi Kawakami   +24 more
doaj   +1 more source

IGFBP2 drives epithelial-mesenchymal transition in hepatocellular carcinoma via activating the Wnt/β-catenin pathway

Infectious Agents and Cancer, 2023
Metastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive.
Xiu Chen, Yu Zhang, Pingping Zhang, Mengzhu Wei, Tian Tian, Yanling Guan, Chenchen Han, Wei Wei, Yang Ma   +8 more
doaj   +1 more source

β2 Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function

Frontiers in Immunology, 2017
Emerging evidence suggests that the β2 integrin family of adhesion molecules have an important role in suppressing immune activation and inflammation.
Leonie Schittenhelm, Leonie Schittenhelm, Leonie Schittenhelm, Catharien M. Hilkens, Catharien M. Hilkens, Vicky L. Morrison, Vicky L. Morrison   +6 more
doaj   +1 more source

NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease

Acta Biochimica et Biophysica Sinica, 2022
The NLRP3 inflammasome is a multiprotein binding compound comprising NLRP3, connector protein ASC, and effector protein pro-caspase-1. When the NLRP3 inflammasome senses a danger signal from the host or pathogen, activated caspase-1 cleaves the ...
Guan Yanling, Gu Yiyue, Li Hao, Liang Bo, Han Chenchen, Zhang Yu, Liu Qian, Wei Wei, Ma Yang   +8 more
doaj   +1 more source

Establishment of a qualified integrated care system after total knee arthroplasty as a role of regional rheumatoid and degenerative arthritis centers

BMC Geriatrics, 2022
Background The geriatric population and advanced knee osteoarthritis are rapidly increasing in Korea, and the socioeconomic burden of total knee arthroplasty (TKA) is increasing.
Eun Young Han, Sang Rim Kim, Kye Hee Cho, Sang Hee Im   +3 more
doaj   +1 more source

Effectiveness of self-management interventions in inflammatory arthritis: a systematic review informing the 2021 EULAR recommendations for the implementation of self-management strategies in patients with inflammatory arthritis

RMD Open, 2021
Objective To perform a systematic review (SR) on the effectiveness of self-management interventions, in order to inform the European League Against Rheumatism Recommendations for its implementation in patients with inflammatory arthritis (IA).Methods The
Andréa Marques, Ailsa Bosworth, Eduardo Santos   +2 more
doaj   +1 more source

‘The current mental health status of children and young people with JIA, and their wider family’: a charity partner collaboration survey

Pediatric Rheumatology Online Journal, 2023
Background This paper presents insight into the scale of mental health concerns for families who have a child or young person with a diagnosis of Juvenile Idiopathic Arthritis (JIA) living in any of the four nations of the United Kingdom (UK).
Polly Livermore, S. Ainsworth, R. Beesley, S. Douglas, E. Earle, D. Wilson, L. Woolley, J. Clinch   +7 more
doaj   +1 more source

Macrophage Rewiring by Nutrient Associated PI3K Dependent Pathways

Frontiers in Immunology, 2019
Class 1 Phosphoinositide-3-Kinases (PI3Ks) have been widely studied and mediate essential roles in cellular proliferation, chemotaxis, insulin sensitivity, and immunity.
Omar Sharif, Omar Sharif, Julia Stefanie Brunner, Julia Stefanie Brunner, Andrea Vogel, Andrea Vogel, Gernot Schabbauer, Gernot Schabbauer   +7 more
doaj   +1 more source

Evaluation of central corneal thickness and corneal curvature in patients with rheumatoid arthritis

Asian Journal of Medical Sciences, 2022
Background: Rheumatoid arthritis is an autoimmune disease. It is a chronic disease that causes symmetrical deforming type of polyarthritis. Rheumatoid arthritis most commonly involves the anterior segment of the eye. It causes keratoconjunctivitis sicca,
Rubina Huda , Syed Ali Nasar Waris , Sankar Kumar T , Panchapakesa Rajendran C   +3 more
doaj   +1 more source