Results 51 to 60 of about 1,802,299 (400)

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites [PDF]

, 2012
Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Al-Riyami, Benderdour, Chu, Collins, Conti, Cooke, Fang, Feng, Goodridge, Goodridge, Goodridge, Gulen, Harnett, Harrington, Ito, Ivanov, Kelchtermans, Kenny, Koenders, Koshy, Kulkarni, Langrish, Lubberts, Marshall, Martin, McInnes, Murugaiyan, Nakae, Naor, Niedbala, Petermann, Pickens, Price, Reynolds, Roark, Sato, Shahrara, Shibata, Staschke, Sutton, Szanto, Takayanagi, Tanaka, Vermeire, Whelan, Xu, Xu, Yago   +47 more
core   +1 more source

Integrating clinician support with intervention design as part of a programme testing stratified care for musculoskeletal pain in general practice

BMC Family Practice, 2021
Background Stratified care involves subgrouping patients based on key characteristics, e.g. prognostic risk, and matching these subgroups to early treatment options.
Joanne Protheroe, Benjamin Saunders, Jonathan C. Hill, Adrian Chudyk, Nadine E. Foster, Bernadette Bartlam, Simon Wathall, Vincent Cooper   +7 more
doaj   +1 more source

Relationship of the medial clavicular head to the manubrium in normal and symptomatic degenerated sternoclavicular joints [PDF]

, 2014
Background: Clavicular prominence is common in patients with symptomatic degenerative sternoclavicular arthritis. It is unclear if this is caused by enlargement or subluxation of the clavicle.
De Wilde, Lieven, Piepers, Iwein, Valcke, Jens, Van Tongel, Alexander, Verschueren, Thomas   +4 more
core   +1 more source

The diagnosis and arthroscopic treatment of angioleiomyoma presenting loose body in the knee joint: two case reports

BMC Musculoskeletal Disorders, 2018
Background Angioleiomyoma is a very rare benign solitary soft tissue neoplasm originating from smooth muscle layer of blood vessels. The tumor is usually located in the subcutis or the superficial fasciae, but less often in the deep fasciae, especially ...
Chenxi Cao, Zhengming Cao, Guangyu Liu, Songyang Liu, Yanqi Ye, Tiezheng Sun   +5 more
doaj   +1 more source

Change in bone mineral density in post menopausal women with rheumatoid arthritis [PDF]

, 2013
Introduction: Low bone mass is a serious complication of post menopausal women with rheumatoid arthritis. We determined the Change in Bone Mineral Density in postmenopausal women with rheumatoid arthritis.
Aghaei, M., Aili, A., Jamshir, M., Khani, S.H., Mohebi, E.G., Pour, N.B., Sedighi, S., Shirashiani, M., Shojaa, M., Zayeni, H.   +9 more
core   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Risk of venous thromboembolism in patients with rheumatoid arthritis: a meta-analysis of observational studies

BMC Rheumatology
Background Thrombotic events, such as venous thromboembolism (VTE) are a major health complication linked to rheumatoid arthritis (RA). We performed a meta-analysis to evaluate the risk of VTE, including deep vein thrombosis (DVT) and pulmonary embolism (
Zahra A Fazal, Ana Michelle Avina-Galindo, Shelby Marozoff, Jessie Kwan, Na Lu, J. Antonio Avina-Zubieta   +5 more
doaj   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Treatment recommendations for psoriatic arthritis [PDF]

, 2008
Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion.
Boehncke, Wolf-Henning, Fiorentino, David, FitzGerald, Oliver, Gladman, Dafna D., Gottlieb, Alice B., Helliwell, Philip, Kavanaugh, Arthur, McHugh, Neil J., Mease, Philip J., Nash, Peter, Qureshi, Abrar A., Ritchlin, Christopher T., Soriano, Enrique R., Taylor, William J., Vlam, Kurt de   +14 more
core   +3 more sources

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source