Results 41 to 50 of about 827,161 (300)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Integrating clinician support with intervention design as part of a programme testing stratified care for musculoskeletal pain in general practice

BMC Family Practice, 2021
Background Stratified care involves subgrouping patients based on key characteristics, e.g. prognostic risk, and matching these subgroups to early treatment options.
Joanne Protheroe, Benjamin Saunders, Jonathan C. Hill, Adrian Chudyk, Nadine E. Foster, Bernadette Bartlam, Simon Wathall, Vincent Cooper   +7 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Stem Cell and Cell-Free Strategies for Osteoarthritis: Toward Durable Regenerative Therapies

Stem Cells International
Osteoarthritis (OA) is the most prevalent degenerative joint disease and a leading cause of pain and disability, yet current treatments remain largely palliative and fail to alter disease progression.
Andreas Pambis, Tianle Li, You Li, Biao Li, Christopher Kim   +4 more
doaj   +1 more source

Mitochondria as Key Players in the Pathogenesis and Treatment of Rheumatoid Arthritis

Frontiers in Immunology, 2021
Mitochondria are major energy-producing organelles that have central roles in cellular metabolism. They also act as important signalling hubs, and their dynamic regulation in response to stress signals helps to dictate the stress response of the cell ...
Sally A. Clayton, Sally A. Clayton, Lucy MacDonald, Lucy MacDonald, Mariola Kurowska-Stolarska, Mariola Kurowska-Stolarska, Andrew R. Clark, Andrew R. Clark   +7 more
doaj   +1 more source

Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton, Carol Hermon, Sarah Floud, Gillian Reeves, Isobel Barnes   +4 more
wiley   +1 more source

Sex Matters

JBJS Open Access
Background:. Despite broad calls to consider sex-specific effects in treatment/intervention studies, this remains a persistent gap. This study sought to identify presurgery factors associated with pain and physical function following hip and knee total ...
Anthony V. Perruccio, PhD, J. Denise Power, PhD, Kala Sundararajan, MSc, Mayilee Canizares, PhD, J. Roderick Davey, MD, Rajiv Gandhi, MD, MSc, Khalid Syed, MD, MEd, Christian Veillette, MD, MSc, Mohit Kapoor, PhD, Nizar N. Mahomed, MD, ScD, Y. Raja Rampersaud, MD   +10 more
doaj   +1 more source

Supported self-management for all with musculoskeletal pain: an inclusive approach to intervention development: the EASIER study

BMC Musculoskeletal Disorders, 2023
Background Supported self-management interventions for patients with musculoskeletal (MSK) conditions may not adequately support those with limited health literacy, leading to inequalities in care and variable outcomes.
Emma L. Healey, Martyn Lewis, Nadia Corp, Noureen A. Shivji, Danielle A. van der Windt, Opeyemi O. Babatunde, Joanna Simkins, Bernadette Bartlam, Gill Rowlands, Joanne Protheroe   +9 more
doaj   +1 more source