Results 41 to 50 of about 1,291,893 (344)

Challenges documenting racial disparities in Merkel cell carcinoma

Cancer Biology & Therapy, 2022
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer that predominantly impacts White patients. Overall incidence and the proportion of minority patients with MCC are both rising.
Mackenzie R. Martin, Noreen Mohsin, Serena Vilasi, Danielle Reed, Isaac Brownell   +4 more
doaj   +1 more source

Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation

Stem Cells Translational Medicine, 2019
Patients with late‐stage Kellgren‐Lawrence knee osteoarthritis received a single intra‐articular injection of 1, 10, or 50 million bone marrow mesenchymal stromal cells (BM‐MSCs) in a phase I/IIa trial to assess safety and efficacy using a broad toolset ...
Jaskarndip Chahal, Alejandro Gómez‐Aristizábal, Konstantin Shestopaloff, Shashank Bhatt, Amélie Chaboureau, Antonietta Fazio, Jolene Chisholm, Amanda Weston, Julia Chiovitti, Armand Keating, Mohit Kapoor, Darrell J. Ogilvie‐Harris, Khalid A. Syed, Rajiv Gandhi, Nizar N. Mahomed, Kenneth W. Marshall, Marshall S. Sussman, Ali M. Naraghi, Sowmya Viswanathan   +18 more
doaj   +1 more source

Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men

Scientific Reports, 2022
Higher plasma leucine, isoleucine and valine (BCAA) concentrations are associated with diabetes, obesity and insulin resistance (IR). Here, we evaluated the effects of 6-weeks very-low calorie diet (VLCD) upon fasting BCAA in overweight (OW) non-diabetic
M. H. Sayda, M. H. Abdul Aziz, N. Gharahdaghi, D. J. Wilkinson, P. L. Greenhaff, B. E. Phillips, K. Smith, I. Idris, P. J. Atherton   +8 more
doaj   +1 more source

Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies

Bone Research, 2018
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens.
Qiang Guo, Yu-Xiang Wang, Dan Xu, J. Nossent, N. Pavlos, Jia-Ke Xu   +5 more
semanticscholar   +1 more source

Improving the outcome of psoriatic arthritis [PDF]

, 2010
Psoriatic arthritis (PsA) is recognised to have a significant impact on functional impairment, joint damage and quality of life. The aim of this thesis was to investigate tools for early identification, to develop a clinical target for treatment and to ...
Coates, Laura Claire
core   +4 more sources

Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor beta-chain [PDF]

, 2010
Introduction: The Vbeta12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)
Burkhardt, H, Dzhambazov, Balik, Bockermann, Robert, Bettina Sehnert, Batsalova, Tsvetelina, Harald Burkhardt, Burkhardt, Harald, Robert Bockermann, Baecklund, Johan, Batsalova, T, Bockermann, R, Dzhambazov, B, Merky, Patrick, Baecklund, J, Bäcklund, Johan, Sehnert, B, Patrick Merky, Sehnert, Bettina, Balik Dzhambazov, Tsvetelina Batsalova, Lund University., Johan Backlund, Merky, P,, Bockermann, Robert,   +23 more
core   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

Arthritis care & research, 2016
To develop a new evidence‐based, pharmacologic treatment guideline for rheumatoid arthritis (RA).
Jasvinder A. Singh, K. Saag, S. Bridges, E. Akl, R. Bannuru, M. C. Sullivan, E. Vaysbrot, Christine McNaughton, M. Osani, R. Shmerling, J. Curtis, D. Furst, D. Parks, A. Kavanaugh, J. O'Dell, Charles King, Amye Leong, E. L. Matteson, J. Schousboe, B. Drevlow, S. Ginsberg, J. Grober, E. S. St Clair, E. Tindall, Amy S. Miller, T. McAlindon   +25 more
semanticscholar   +1 more source

The etiology of rheumatoid arthritis.

Journal of Autoimmunity, 2020
Rheumatoid arthritis is a heterogeneous disease, which can be, based on data combining genetic risk factors and autoantibodies, sub-classified into ACPA-positive and -negative RA.
H. Scherer, T. Häupl, G. Burmester
semanticscholar   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source