Results 51 to 60 of about 1,005,051 (309)

Integrating clinician support with intervention design as part of a programme testing stratified care for musculoskeletal pain in general practice

BMC Family Practice, 2021
Background Stratified care involves subgrouping patients based on key characteristics, e.g. prognostic risk, and matching these subgroups to early treatment options.
Joanne Protheroe, Benjamin Saunders, Jonathan C. Hill, Adrian Chudyk, Nadine E. Foster, Bernadette Bartlam, Simon Wathall, Vincent Cooper   +7 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Stem Cell and Cell-Free Strategies for Osteoarthritis: Toward Durable Regenerative Therapies

Stem Cells International
Osteoarthritis (OA) is the most prevalent degenerative joint disease and a leading cause of pain and disability, yet current treatments remain largely palliative and fail to alter disease progression.
Andreas Pambis, Tianle Li, You Li, Biao Li, Christopher Kim   +4 more
doaj   +1 more source

Validation of the Pediatric Arthritis Ultrasound Scoring System for the Elbow, Wrist, and Finger Joints in Children With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective We aimed to validate the Pediatric Arthritis Ultrasound Scoring System (PAUSS) for upper extremity joints in children with juvenile idiopathic arthritis (JIA). Methods Children with JIA were evaluated for elbow, wrist, or finger arthritis by clinical examination (CE) and musculoskeletal ultrasound (MSUS) with images scored according to the ...
Patricia Vega‐Fernandez, Pinar Ozge Avar‐Aydin, Kelly Rogers, Daniel J. Lovell, Jennifer Huggins, Alexei Grom, Hermine I. Brunner, Grant S. Schulert, Sheila T. Angeles‐Han, Mekibib Altaye, Amy Cassedy, Arthur B. Meyers, Tracy V. Ting   +12 more
wiley   +1 more source

Sex Matters

JBJS Open Access
Background:. Despite broad calls to consider sex-specific effects in treatment/intervention studies, this remains a persistent gap. This study sought to identify presurgery factors associated with pain and physical function following hip and knee total ...
Anthony V. Perruccio, PhD, J. Denise Power, PhD, Kala Sundararajan, MSc, Mayilee Canizares, PhD, J. Roderick Davey, MD, Rajiv Gandhi, MD, MSc, Khalid Syed, MD, MEd, Christian Veillette, MD, MSc, Mohit Kapoor, PhD, Nizar N. Mahomed, MD, ScD, Y. Raja Rampersaud, MD   +10 more
doaj   +1 more source

Supported self-management for all with musculoskeletal pain: an inclusive approach to intervention development: the EASIER study

BMC Musculoskeletal Disorders, 2023
Background Supported self-management interventions for patients with musculoskeletal (MSK) conditions may not adequately support those with limited health literacy, leading to inequalities in care and variable outcomes.
Emma L. Healey, Martyn Lewis, Nadia Corp, Noureen A. Shivji, Danielle A. van der Windt, Opeyemi O. Babatunde, Joanna Simkins, Bernadette Bartlam, Gill Rowlands, Joanne Protheroe   +9 more
doaj   +1 more source

Mitochondria as Key Players in the Pathogenesis and Treatment of Rheumatoid Arthritis

Frontiers in Immunology, 2021
Mitochondria are major energy-producing organelles that have central roles in cellular metabolism. They also act as important signalling hubs, and their dynamic regulation in response to stress signals helps to dictate the stress response of the cell ...
Sally A. Clayton, Sally A. Clayton, Lucy MacDonald, Lucy MacDonald, Mariola Kurowska-Stolarska, Mariola Kurowska-Stolarska, Andrew R. Clark, Andrew R. Clark   +7 more
doaj   +1 more source

Sex Differences in Medication Discontinuation in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall, Cinthia Blat, Eric Roberts, Jean W. Liew, Katherine Wysham, Namrata Singh, Janna Friedly, Lianne S. Gensler, Gabriela Schmajuk, Jinoos Yazdany   +9 more
wiley   +1 more source

The accelerometer-based navigation system demonstrated superior radiological outcomes in restoring mechanical alignment and component sagittal positioning in total knee arthroplasty

BMC Musculoskeletal Disorders, 2021
Background This study aimed to determine whether the accelerometer-based navigation (ABN) could improve the accuracy of restoring mechanical axis (MA), component positioning, and clinical outcomes compared to conventional (CON) total knee arthroplasty ...
Jiaxiang Gao, Yunfei Hou, Rujun Li, Yan Ke, Zhichang Li, Jianhao Lin   +5 more
doaj   +1 more source