Results 51 to 60 of about 1,291,893 (344)

Risk of venous thromboembolism in patients with rheumatoid arthritis: a meta-analysis of observational studies

BMC Rheumatology
Background Thrombotic events, such as venous thromboembolism (VTE) are a major health complication linked to rheumatoid arthritis (RA). We performed a meta-analysis to evaluate the risk of VTE, including deep vein thrombosis (DVT) and pulmonary embolism (
Zahra A Fazal, Ana Michelle Avina-Galindo, Shelby Marozoff, Jessie Kwan, Na Lu, J. Antonio Avina-Zubieta   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The diagnosis and arthroscopic treatment of angioleiomyoma presenting loose body in the knee joint: two case reports

BMC Musculoskeletal Disorders, 2018
Background Angioleiomyoma is a very rare benign solitary soft tissue neoplasm originating from smooth muscle layer of blood vessels. The tumor is usually located in the subcutis or the superficial fasciae, but less often in the deep fasciae, especially ...
Chenxi Cao, Zhengming Cao, Guangyu Liu, Songyang Liu, Yanqi Ye, Tiezheng Sun   +5 more
doaj   +1 more source

Global research trends in extracellular vesicles based on stem cells from 1991 to 2021: A bibliometric and visualized study

Frontiers in Bioengineering and Biotechnology, 2022
Objective: With the development of extracellular vesicles (EVs) based on stem cells research all over the world, our present study was aiming to discover the global trends in this field.Methods: All publications related to EVs based on stem cells from ...
Jianjing Lin, Jianjing Lin, Jianjing Lin, Zhen Yang, Zhen Yang, Li Wang, Dan Xing, Dan Xing, Jianhao Lin, Jianhao Lin   +9 more
doaj   +1 more source

The Immunology of Rheumatoid Arthritis

Nature Immunology, 2020
The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the production of autoantibodies against post-translationally modified proteins (checkpoint 1).
C. Weyand, J. Goronzy
semanticscholar   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Mesenchymal stromal cells immunosuppress osteoarthritis synovial fluid modulated monocytes via IL-6 and CCL2

Cell Death and Disease
Mesenchymal stromal cell (MSC) interactions with monocytes/macrophages are central to their therapeutic effects in knee osteoarthritis (KOA); however, mechanisms of these interactions are not fully understood.
Mozhgan Rasti, Aida Feiz Barazandeh, Shahrzad Nouri, Kevin P. Robb, Rachel Low, Oreoluwa Kolade, Kevin Fan, Rajiv Gandhi, Sowmya Viswanathan   +8 more
doaj   +1 more source

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

Nature Communications, 2020
Gut microbial dysbiosis is associated with the development of autoimmune disease, but the mechanisms by which microbial dysbiosis affects the transition from asymptomatic autoimmunity to inflammatory disease are incompletely characterized.
N. Tajik, M. Frech, Oscar Schulz, F. Schälter, S. Lucas, V. Azizov, K. Dürholz, Franziska Steffen, Y. Omata, A. Rings, M. Bertog, A. Rizzo, A. Iljazović, M. Basic, A. Kleyer, S. Culemann, G. Krönke, Yu-Bin Luo, K. Überla, U. Gaipl, B. Frey, T. Strowig, K. Sarter, S. Bischoff, S. Wirtz, J. Cañete, Francesco Ciccia, G. Schett, M. Zaiss   +28 more
semanticscholar   +1 more source

Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

Nature Communications, 2021
Insufficient apoptosis of inflammatory macrophages and osteoclasts (OCs) in rheumatoid arthritis (RA) joints contributes toward the persistent progression of joint inflammation and destruction.
C. Deng, Quan Zhang, Peng-Hui He, Bin Zhou, Ke He, Xun Sun, G. Lei, Tao Gong, Zhi-Rong Zhang   +8 more
semanticscholar   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source