Results 41 to 50 of about 9,355 (209)

A comparison of abrasion burr arthroplasty and subchondral drilling in the treatment of full‐thickness cartilage lesions in the rabbit

Arthroscopy, 1996
Abstract The purpose of this study was to observe the difference in healing of full‐thickness articular cartilage defects treated with burr arthroplasty versus subchondral drilling. Cartilage was shaved off the medial femoral condyles of 39 rabbits without penetrating the subchondral plate. In left knees, two 2.0‐mm holes were drilled
D S, Menche, S R, Frenkel, B, Blair, N F, Watnik, B C, Toolan, R S, Yaghoubian, M I, Pitman   +6 more
openaire   +2 more sources

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

Differences in subchondral trabecular bone microstructure and finite element analysis-based biomechanical properties between osteoporosis and osteoarthritis

Journal of Orthopaedic Translation, 2020
Summary: Background/Objective: The microstructure of the subchondral trabecular bone, including the composition and distribution of plates and rods, has an important influence on the disease progression and mechanical properties of osteoarthritis (OA ...
Zihao He, Linyang Chu, Xuqiang Liu, Xuequan Han, Kai Zhang, Mengning Yan, Xiaofeng Li, Zhifeng Yu   +7 more
doaj   +1 more source

β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis

Open Medicine, 2022
An important causative factor in osteoarthritis (OA) is the abnormal mechanical stress-induced bone remodeling of the subchondral bone. β2-adrenergic receptor (Adrb2) plays a major role in mechanical stresses that induce bone remodeling.
Yang Xiaochun, Liang Xuegang, Guo Haohui, Ma Long, Jian Li, Zhao Xin, Wang Jian, Yang Lvlin, Meng Zhiqiang, Jin Qunhua   +9 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Medialization of Cementless Acetabular Components after the Removal of Subchondral Bone in Total Hip Arthroplasty

Journal of the Korean Orthopaedic Association, 2003
Purpose : To evaluate the results of cementless cup fixation in primary total hip arthroplasties (THAs) involving removal of acetabular subchondral bone and medial placement of a cementless cup. Materials and Methods : Forty-three primary THAs, in which the subchondral bone of acetabulum was removed and the cementless cup was placed medially, were ...
Jeong Joon Yoo, Won Sook Song, Young Min Kim, Hee Joong Kim   +3 more
openaire   +1 more source

An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans

Cells, 2021
Chondrocyte-based cartilage repair strategies, such as articular chondrocyte implantation, are widely used, but few studies addressed the communication between native subchondral bone cells and the transplanted chondrocytes.
Timothy Hopkins, Karina T. Wright, Nicola J. Kuiper, Sally Roberts, Paul Jermin, Peter Gallacher, Jan Herman Kuiper   +6 more
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Female Patients Exhibit a Narrower Glenoid Rim and Lower Bone Density in the Anteroinferior Quadrant Compared With Male Patients

Arthroscopy, EarlyView.
Purpose The purpose of this study was to evaluate sex‐based differences in glenoid rim morphology and bone density relevant to arthroscopic Bankart repair. Methods This retrospective study assessed differences in glenoid rim morphology between sexes in patients with shoulder instability and uninjured control subjects who underwent a magnetic resonance ...
Willem Geuskens, Haider Ali Lakdawala, Maïté Jaspers, Tom Doyle, Damir Rasidovic, Olivier Verborgt, Oisin Flanagan, Eoghan Hurley, Hannan Mullett   +8 more
wiley   +1 more source

Biointegrative fiber-reinforced implants for fixation of subchondral insufficiency with avascular necrosis: a case report

Journal of Cartilage & Joint Preservation
Introduction: Treating avascular necrosis (AVN) of the knee can be challenging, particularly at later stages of progression. After subchondral collapse occurs, the only existing surgical treatment is arthroplasty.
Sarah A. Muth, Alexander C. Weissman, Allen A. Yazdi, Katie J. McMorrow, Richard M. Danilkowicz, Brian J. Cole   +5 more
doaj   +1 more source