Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis
Frontiers in Cell and Developmental Biology, 2021 There is emerging awareness that subchondral bone remodeling plays an important role in the development of osteoarthritis (OA). This review presents recent investigations on the cellular and molecular mechanism of subchondral bone remodeling, and ...
Xiaobo Zhu +9 more
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Density and strength distribution of the subchondral bone plate of the canine talus [PDF]
Frontiers in Veterinary ScienceIntroductionThe subchondral bone plate plays a critical role in load transfer across joints. Its density distribution reflects the joint’s loading history, and variations in density are likely associated with changes in the material properties of the ...
Yasamin Vali +4 more
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The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis
Frontiers in Veterinary Science, 2018 Subchondral bone plays a critical role in the pathogenesis of osteochondral disease across veterinary species. The subchondral bone is highly adaptable, with the ability to model and remodel in response to loading stresses experienced by the joint ...
Holly L. Stewart, Christopher E. Kawcak
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Senescent bone marrow mesenchymal stem cells exacerbate subchondral bone sclerosis and osteoarthritis via the senescence-associated secretory phenotype [PDF]
Stem Cell Research & TherapyBackground Osteoarthritis (OA) is a common joint disease characterized by articular cartilage degeneration, with subchondral bone sclerosis being a key pathological change.
Dinglong Yang +9 more
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FSCN1 induces subchondral bone sclerosis in osteoarthritis via modulating actin cytoskeleton dynamics and YAP signaling [PDF]
Arthritis Research & TherapyBackground Subchondral bone is a dynamic tissue maintained by bone remodeling and responded rapidly to mechanical loading, which is strongly associated with cartilage degradation in osteoarthritis (OA), but the underlying mechanisms of which is still ...
Yun Xiao +11 more
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Moxibustion ameliorates abnormal subchondral bone remodeling by promoting ACSL1-mediated autophagy to degrade NLRP3 in osteoarthritis [PDF]
Chinese MedicineBackground Osteoarthritis (OA) is a joint disorder that is characterized, among other features, by abnormal subchondral bone remodeling. Moxibustion, a traditional Chinese medicine treatment, has a long history in the clinical treatment of osteoarthritis
Xuelan Chen +6 more
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Peripheral nerves in the tibial subchondral bone: the role of pain and homeostasis in osteoarthritis
Bone & Joint Research, 2022 Osteoarthritis (OA) is a highly prevalent degenerative joint disorder characterized by joint pain and physical disability. Aberrant subchondral bone induces pathological changes and is a major source of pain in OA.
Qi Sun +6 more
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Inhibition of PGE2 in Subchondral Bone Attenuates Osteoarthritis
Cells, 2022 Aberrant subchondral bone architecture is a crucial driver of the pathological progression of osteoarthritis, coupled with increased sensory innervation.
Qi Sun +7 more
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Scientific Reports, 2023 This study aimed to investigate the additional effect of ovariectomy-induced osteoporosis (OP) on the pathology of knee osteoarthritis (OA) in a rat meniscectomized model, particularly focusing on subchondral bone changes and pain behaviour.
Hiroyuki Wada +3 more
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IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes
Experimental and Molecular Medicine, 2023 Osteoarthritis (OA) is a degenerative joint disease. While it is classically characterized by articular cartilage destruction, OA affects all tissues in the joints and is thus also accompanied by local inflammation, subchondral bone changes, and ...
Gyeong Min Kim +4 more
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