Results 11 to 20 of about 36,100 (249)
Subchondral bone microenvironment in osteoarthritis and pain [PDF]
Bone Research, 2021 Osteoarthritis comprises several joint disorders characterized by articular cartilage degeneration and persistent pain, causing disability and economic burden.
Yan Hu +4 more
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Subchondral bone histology and grading in osteoarthritis. [PDF]
PLoS ONE, 2017 OBJECTIVE:Osteoarthritis (OA) has often regarded as a disease of articular cartilage only. New evidence has shifted the paradigm towards a system biology approach, where also the surrounding tissue, especially bone is studied more vigorously.
Olli-Matti Aho +4 more
doaj +6 more sources
Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice
eLife, 2021 Osteoarthritis, a highly prevalent degenerative joint disorder, is characterized by joint pain and disability. Available treatments fail to modify osteoarthritis progression and decrease joint pain effectively. Here, we show that intermittent parathyroid
Qi Sun +13 more
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Frontiers in Genetics, 2022 Kashin-Beck disease (KBD) is an endemic, degenerative osteoarthropathy that exhibits some similar characteristics to osteoarthritis (OA) but with different etiologies and pathogeneses. In addition to cartilage damage, microstructural changes of bone were
Lei Yang +6 more
doaj +1 more source
Microstructural adaptations of the subchondral bone are related to the mechanical axis deviation in end stage varus OA knees [PDF]
European Cells & Materials, 2023 Recent studies highlighted the crucial contribution of subchondral bone to OA development. Yet, only limited data have been reported on the relation between alteration to cartilage morphology, structural properties of the subchondral bone plate (SBP) and
W Colyn +4 more
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Frontiers in Pharmacology, 2021 Osteoarthritis (OA) is the most common type of arthritis with no effective therapy. Subchondral bone and overlying articular cartilage are closely associated and function as “osteo-chondral unit” in the joint.
Wang Yajun +19 more
doaj +1 more source
Insights into Imaging, 2023 Subchondral insufficiency fractures (SIFs) and SIFs with osteonecrosis (SIF-ONs) of the knee (previously misnamed spontaneous osteonecrosis of the knee (SONK)) are bone lesions that appear without prior traumatic, tumoral, or inflammatory event.
Jacques Malghem +4 more
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Hemodynamic stress shapes subchondral bone in osteoarthritis: An emerging hypothesis
Journal of Orthopaedic Translation, 2022 Osteoarthritis (OA) is no longer regarded as a simple wear-and-tear problem of articular cartilage. Instead, OA is a whole joint disorder involving both cartilaginous and non-cartilaginous tissues such as subchondral bone and synovium.
Ruiyan Ni +3 more
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Subchondral bone remodelling in osteoarthritis [PDF]
EFORT Open Reviews, 2019 Subchondral bone remodelling is an integral part of osteoarthritis and involves the development of subchondral sclerosis seen on plain imaging, along with osteophyte formation. The development of these changes is due to persistent abnormal mechanical stresses which create a cellular and biomolecular response to microfractures in the subchondral bone ...
openaire +3 more sources
Cyst formation in the subchondral bone following cartilage repair
Clinical and Translational Medicine, 2020 Subchondral bone cysts represent an early postoperative sign associated with many articular cartilage repair procedures. They may be defined as an abnormal cavity within the subchondral bone in close proximity of a treated cartilage defect with a ...
Liang Gao +2 more
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