Results 91 to 100 of about 56,529,051 (299)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
¿Es el artículo una unidad pragmática? Acerca de la teoría de la definitud y la referencia
Studia Romanica Posnaniensia, 2021 In this paper I intend to review some theories of the article, paying attention to the relations they establish between reference and +/–definiteness of a noun phrase (NP).
Janusz Pawlik
doaj
At Bjelland Vineyards Outlook Is Exciting Article [PDF]
, 1974 This article focuses on Bjelland Vineyards and its prospects for future growth and development. Paul Bjelland is interviewed about the sales of Bjelland wines around the world, as well as some of the trials he faces as a vintner.
The News-Review
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
THE SPECIFICITY OF CORRELATION CATEGORY REALIZATION IN THE MODERN GERMAN LANGUAGE
Вестник Волгоградского государственного университета: Серия 2. Языкознание, 2014 The article studies the German article in functional aspect taking into account the conception of the grammatical category of correlation / non-correlation, proposed by L.R. Zinder and T.V. Stroeva. The author describes the specificity of the correlation
Goryunova Yuliya Nikolaevna
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Relationship between Science Indicator and Life Expectancy in Pioneer Countries [PDF]
Taṣvīr-i salāmat, 2016 Background and Objectives : The main objective of this study was to investigate the relationship between scientific productivity in the field of psychiatry and life expectancy in pioneer countries.
Maryam Moghadami +2 more
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source