Results 61 to 70 of about 60,954,879 (392)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

open access: yesFEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li   +3 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Roseburg Wine Praised Article [PDF]

open access: yes, 1973
Wines from Bjelland Winery and Hillcrest Vineyard are compared and contrasted. Both white and red wines from Southern Oregon are praised for their exceptional quality.
Van Renssalaer, Jim
core   +1 more source

The Relationship between Science Indicator and Life Expectancy in Pioneer Countries [PDF]

open access: yesTaṣvīr-i salāmat, 2016
​Background and Objectives : The main objective of this study was to investigate the relationship between scientific productivity in the field of psychiatry and life expectancy in pioneer countries.
Maryam Moghadami   +2 more
doaj  

Peer-reviewed publications as an element of the state system of scientific attestation

open access: yesПравоприменение, 2022
The aim of the work is to analyze peer-reviewed scientific publications as an element of the state system of scientific attestation in order to improve its regulatory legal regulation.
A. V. Bodrov, S. V. Narutto
doaj   +1 more source

Survey Article: Inter-Coder Agreement for Computational Linguistics

open access: yesInternational Conference on Computational Logic, 2008
This article is a survey of methods for measuring agreement among corpus annotators. It exposes the mathematics and underlying assumptions of agreement coefficients, covering Krippendorff's alpha as well as Scott's pi and Cohen's kappa; discusses the use
Ron Artstein, Massimo Poesio
semanticscholar   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

open access: yesFEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Article XXII: Depositary/ies [PDF]

open access: yes, 1999
Ye
Pearson, Graham S., Sims, N.A.
core  

The process of harnessing solar power through the Ashwamedha Yagya.

open access: yesDev Sanskriti: Interdisciplinary International Journal
The first Ashwamedha Yagya under the Dev Sanskriti Digvijay Abhiyan of the All World Gayatri Family took place in Jaipur, Rajasthan from November 7th to 10th, 1992.
Reprint
doaj   +1 more source

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