Results 21 to 30 of about 187,372 (271)

The European Parliament: On the Politics of Naming

open access: yesPolitics and Governance
In this article, I discuss the early history of the expression of the European Parliament and analyse the political points of its different rhetorical nuances and connotations.
Kari Palonen
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Симультанна нітрифікація-денітрифікація в SBR з плаваючими EPS-носіями для молочних стічних вод

open access: yesСучасні технології та методи розрахунків у будівництві
The article presents the results of an experimental study and mathematical modelling of simultaneous nitrification-denitrification (SND) in an IFAS-SBR system with floating expanded polystyrene (EPS) carriers for treatment of dairy wastewater ...
І. В. Кобилко
semanticscholar   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Basics of worker safety under the draft Labour Code of Ukraine

open access: yesUzhhorod National University Herald. Series: Law
The article analyses the draft Labour Code of Ukraine with regard to legal regulation of safety and health of employees. The author examines in detail Book Three «Safety and Health of Employees» of the draft Labour Code of Ukraine.
O. Pozharova, Y. Pozharov
semanticscholar   +1 more source

Lithuania’s Binary Worker Classification Vs. A Teleological Interpretation of the EU’s ‘Worker’ Concept by Germany and the UK

open access: yesBaltic Journal of Law & Politics
The article explores whether Lithuania’s concept of darbuotojas (employee) and its rigid binary classification of work relationships is challenged by an evolving European employment law landscape, shaped by a rise of unconventional work relationships ...
Lauschke Hans
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Jednolity rynek europejski jako fundament i motor integracji europejskiej

open access: yes, 2015
The European Single Market is a key factor in the process of European integration. Rudiments of its construction have been created by three founding treaties, but the most important was the Treaty of Rome (1957), establishing the European Economic ...
I. Pietrzyk
semanticscholar   +1 more source

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