Results 41 to 50 of about 3,253,670 (325)
FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti +2 more
wiley +1 more source
FEBS Letters, Volume 599, Issue 7, Page 952-970, April 2025.The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang +9 more
wiley +1 more source
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, Volume 599, Issue 8, Page 1146-1158, April 2025.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
FEBS Letters, Volume 599, Issue 6, Page 876-891, March 2025.We explore 5HT2A receptor activation, a key target for psychedelic drugs, using molecular dynamics simulations. Without Gqα, the active receptor collapses to an inactive conformation, underscoring the G‐protein's role. Discovery of an intermediate “partially‐open” state and the higher affinity of ligands to the orthosteric binding site provides ...
Niklas Viohl +2 more
wiley +1 more source
Physical aging in article page views [PDF]
arXiv, 2016 Statistics of article page views is useful for measuring the impact of individual articles. Analyzing the temporal evolution of article page views, we find that article page views usually decay over time after reaching a peak, especially exhibiting relaxation with nonexponentiality.
arxiv
Research Integrity and Peer Review, 2019 Preprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles.
C. F. D. Carneiro +20 more
semanticscholar +1 more source
FEBS Letters, Volume 599, Issue 8, Page 1113-1121, April 2025.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
From Citation count to Argumentation count: a new metric to indicate the usefulness of an article [PDF]
arXiv, 2014 Citation count is a quantifiable measure to indicate the number of times an article is cited by other articles. It is believed that if an article is cited often then it must be an important or influential article; however, there is no guarantee that the most cited articles are good in quality.
arxiv
On the differentiability of interval functions [PDF]
arXiv, 2021 Two articles published by Information Science discuss the derivatives of interval functions, in the sense of Svetoslav Markov. The authors of these articles tried to characterize for which functions and points such derivatives exist. Unfortunately, their characterization is inaccurate.
arxiv