Results 111 to 120 of about 173,109 (331)
Advanced Science, EarlyView.A compartmentalized joint‐on‐chip (JoC) platform is here developed, modelling the interactions between cartilage and synovium in osteoarthritis (OA). Using independent culture and mechanical/biochemical stimulation, the JoC revealed how inflammation and mechanical damage drive mutual tissue changes.
Cecilia Palma +6 more
wiley +1 more source
Arthroscopy Techniques, 2016 Articular cartilage damage of the knee can cause severe morbidity. Owing to its avascular nature, articular cartilage has limited potential for self-healing and increased propensity to progress to osteoarthritis.
Chase S. Dean, M.D. +3 more
doaj +1 more source
Advanced Science, EarlyView.This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding +14 more
wiley +1 more source
Advanced Science, EarlyView.Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen +14 more
wiley +1 more source
Advances in understanding cartilage remodeling [v1; ref status: indexed, http://f1000r.es/5e6]
F1000Research, 2015 Cartilage remodeling is currently among the most popular topics in osteoarthritis research. Remodeling includes removal of the existing cartilage and replacement by neo-cartilage.
Yefu Li, Lin Xu
doaj +1 more source
The Contact Between the Articular Cartilage and the Medullary Cavities of the Bone [PDF]
, 1950 D. E. Holmdahl, Bo E. Ingelmark
openalex +1 more source
Experimental joint immobilization in guinea pigs. Effects on the knee joint [PDF]
In young and adult guinea pigs, the aftermath experimentally induced by the immobilization of the knee joint in hyperextended forced position was studied. Joint immobilization which varied from one to nine weeks was attained by plaster.
Machado, F. F. +3 more
core +1 more source
Cationic Peptoids for Systemic In Vivo Cartilage‐Targeting
Advanced Science, EarlyView.Systemically‐dosed Cy5‐labeled cationic peptoid probe (NlysO)7 (yellow) binds to the cartilage's glycosaminoglycan content in vivo across the entire body of a neonatal mouse imaged by light sheet fluorescence microscopy, revealing fluorescence uptake in generic cartilage as well as the developing and ossifying bones.
Chaonan Zhang +6 more
wiley +1 more source
Biocompatible Mesoporous Materials for Bone Therapy
Advanced Science, EarlyView.Biocompatible mesoporous materials (BMMs), characterized by high specific surface area, tunable pore size, different shapes and structures, and multidimensional functionalized modifications, have revolutionary applications in treating bone‐related diseases.
Biao Yu +6 more
wiley +1 more source