Results 121 to 130 of about 447,945 (376)
Advanced Science, EarlyView.The present study identified the key protein ORM1 through the proteomic analysis of synovial fluid samples from patients with temporomandibular joint osteoarthritis (TMJOA), and demonstrated the important role of ORM1 in maintaining cartilage homeostasis via the suppression of VIM/MAPK/MMP signalling.
Dahe Zhang +5 more
wiley +1 more source
The superficial zone of articular cartilage
Inflammation and Regeneration, 2022 AbstractThe superficial zone of articular cartilage contributes to smooth joint motion through the production of proteoglycan 4 (PRG4), also known as lubricin. Recent studies indicate novel effects of PRG4 as a signaling molecule, other than a simple extracellular matrix protein.
openaire +3 more sources
Advanced Science, EarlyView.This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li +9 more
wiley +1 more source
Advanced Science, EarlyView.A structurally and functionally dual bionic bone adhesive is engineered through an organic–inorganic cohesion strategy, which significantly reinforces the adhesive's bone tissue adhesion as well as osteogenic activity. In a pioneering rabbit radius comminuted fracture model, the bone adhesive exhibits exceptional capability in immobilizing bone ...
Junyao Cheng +13 more
wiley +1 more source
Advanced Science, EarlyView.Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen +14 more
wiley +1 more source
Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes. [PDF]
, 2007 OBJECTIVE: The normal structure and function of articular cartilage are the result of a precisely balanced interaction between anabolic and catabolic processes.
Jimenez, Sergio A. +2 more
core +1 more source
Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration
Advanced Science, EarlyView.The supramolecular lubricating hydrogel microspheres can provide stable mechanophysical protection at damaged matrix through interfacial hydration lubrication: in the early and middle stages, microspheres can actively provide microscale supramolecular lubrication (µ ≈ 0.04) for damaged matrix; in the late stage, the wear debris induced by shear and ...
Hui Yuan +3 more
wiley +1 more source
Experimental joint immobilization in guinea pigs. Effects on the knee joint [PDF]
In young and adult guinea pigs, the aftermath experimentally induced by the immobilization of the knee joint in hyperextended forced position was studied. Joint immobilization which varied from one to nine weeks was attained by plaster.
Machado, F. F. +3 more
core +1 more source
The Contact Between the Articular Cartilage and the Medullary Cavities of the Bone [PDF]
, 1950 D. E. Holmdahl, Bo E. Ingelmark
openalex +1 more source
Advanced Science, EarlyView.Cartilage injury is a prominent pathological hallmark of osteoarthritis. In this study, we developed a two‐modular hydrogel microparticle system wherein HMP‐A effectively targets the damaged area, while HMP‐B forms an efficient connection with HMP‐A on the cartilage surface.
Xinye Chen +5 more
wiley +1 more source