Results 121 to 130 of about 173,109 (331)

Effects of immobilization on articular cartilage: Autohistoradiographic findings with S35 [PDF]

open access: yes
The effect of immobilization on the articular cartilage of rabbits was studied by light microscope. The knee joint of each rabbit was immobilized in a plaster in a position midway between flexion and extension for a 10 to 120 days period.
Desantis, E., Digiovanni, C.
core   +1 more source

Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
Centimeter‐scale tendon organoids are engineered by mimicking the extracellular matrix and optimizing chemical cues to guide tendon stem/progenitor cells. These large, self‐assembling constructs overcome conventional size limitations and exhibit enhanced tenogenic differentiation, extracellular matrix production, and mechanical resilience. Their tissue‐
Tianshun Fang   +16 more
wiley   +1 more source

Bony island within the articular cartilage of the knee in a child: a rare condition for early osteoarthritis

open access: yesOrthopedic Reviews, 2011
Articular cartilage is a specific type of connective tissue composed of hydrated proteoglycans within a matrix of collagen fibrils. In the elderly population, it shows degenerative changes that may results in osteoarthritis.
Taku Hatta   +5 more
doaj   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

open access: yesAdvanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang   +19 more
wiley   +1 more source

Mechanisms and Pathophysiological Significance of Insulin Resistance in Offspring With Intrauterine Growth Restriction Mediated by Hepatic GR/miR‐1224 Programming

open access: yesAdvanced Science, EarlyView.
This work found that early‐stage insulin sensitization but late‐stage insulin resistance in prenatal caffeine exposure (PCE)‐ induced intrauterine growth restriction (IUGR) offspring may be related to the hepatic AGEs accumulation via intrauterine GR/miR‐1224 programming by glucocorticoids.
Yongguo Dai   +5 more
wiley   +1 more source

DNA‐Based Hydrogels for Musculoskeletal Reconstruction: Harnessing Dynamic Programmability and Multimodal Therapeutic Integration

open access: yesAdvanced Science, EarlyView.
DNA‐based hydrogels serve dual roles as structural scaffolds and therapeutic platforms, offering innovative solutions for musculoskeletal regeneration with multifunctional abilities. Abstract Musculoskeletal disorders, including bone fractures, osteoarthritis, and muscle injuries, represent a leading cause of global disability, revealing the urgency ...
Ruijianghan Shi   +4 more
wiley   +1 more source

Ultra‐Robust Conductive Hydrogels Enabled by a Gradient Bond‐Breaking Pseudo‐Drying Strategy

open access: yesAdvanced Science, EarlyView.
A bioinspired PVA‐ANFs hydrogel, engineered via novel gradient bond‐breaking, achieves unprecedented mechanical performance: ultrahigh strength (≈18 MPa), modulus (≈12 MPa), toughness (≈74 MJ/m3), and record fracture energy (≈269 kJ m−2). It exhibits cryogenic flexibility (−70°C), high ionic conductivity (936.3 mS m−1), and biocompatibility.
Dongchao Ji   +11 more
wiley   +1 more source

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