Results 81 to 90 of about 110,448 (314)
Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment
Advanced Science, EarlyView.Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen +15 more
wiley +1 more source
The thickness of the calcified layer in different joints of a single individual [PDF]
, 1987 The thickness of the articular cartilage and its calcified zone were both measured at specially chosen places in several limb joints from five subjects.
Müller-Gerbl, Magdalena +2 more
core +1 more source
Mesenchymal Stem Cells for Treating Articular Cartilage Defects and Osteoarthritis
Cell Transplantation, 2015 Articular cartilage damage and osteoarthritis are the most common joint diseases. Joints are prone to damage caused by sports injuries or aging, and such damage regularly progresses to more serious joint disorders, including osteoarthritis, which is a ...
Yu Wang +4 more
doaj +1 more source
Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing
Advanced Science, EarlyView.Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan +13 more
wiley +1 more source
, 2007 Articular cartilage is likely a major candidate to be successfully regenerated by tissue engineering methods; first commercial products have already reached the market. However, to fully regenerate articular cartilage tissue, further optimization appears
Appel, Bernhard
core +1 more source
In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]
, 2010 We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Candrian, Christian +9 more
core +1 more source
THE THERAPEUTIC TACTICS OF INTRA-ARTICULAR FRACTURES OF THE ANKLE (LITERATURE REVIEW)
Acta Biomedica Scientifica, 2013 As a result of the analysis of literature it was revealed that in case of pronation-abduction ankle injury takes place injury of the articular surfaces. The hyaline cartilage significantly suffers.
I. V. Zedgenidze, N. V. Tishkov
doaj
Advanced Science, EarlyView.An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng +9 more
wiley +1 more source
Joint contact modelling of articular cartilage in synovial joints [PDF]
, 2010 Hip joint is one of the important load bearing joints and has been extensively studied to investigate contact mechanics and tribology. It has known to experience high contact forces and stresses.
ath Shrikant, Sainath Shrikant +1 more
core
Chondrogenic potential of human articular chondrocytes and skeletal stem cells: a comparative study
, 2015 Regenerative medicine strategies have increasingly focused on skeletal stem cells (SSCs), in response to concerns such as donor site morbidity, dedifferentiation and limited lifespan associated with the use of articular chondrocytes for cartilage repair.
Li, Siwei +3 more
core +1 more source