Results 121 to 130 of about 139,262 (370)

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, EarlyView.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

The experimental study of mir‐99a‐5p negative regulation of TLR8 receptor mediated‐mediated innate immune response in rabbit knee cartilage injury

Immunity, Inflammation and Disease
Background Traumatic cartilage injury is an important cause of osteoarthritis (OA) and limb disability, and toll‐like receptors (TLRs) mediated innate immune response has been confirmed to play a crucial role in cartilage injury.
Jiebin Zhang, Ke Zheng, Yichao Wu, Shengting Zhang, Ao Guo, Cong Sui   +5 more
doaj   +1 more source

Lubricin Immunohistochemical Expression in Human Temporomandibular Joint Disc with Internal Derangement [PDF]

, 2011
Lubricin is a chondroprotective, mucinous glycoprotein which contribute to joint lubrication, especially to boundary lubrication and maintains joint integrity.
Almeida, Luis Eduardo, Leonardi, Rosalia, Loreto, Carla   +2 more
core   +2 more sources

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

T1ρ-based fibril-reinforced poroviscoelastic constitutive relation of human articular cartilage using inverse finite element technology [PDF]

, 2019
BackgroundMapping of T1ρ relaxation time is a quantitative magnetic resonance (MR) method and is frequently used for analyzing microstructural and compositional changes in cartilage tissues.
Alliston, Tamara, Ge, Liang, Hao, Zhixiu, Li, Xiaojuan, Souza, Richard B, Tang, Simon Y, Wan, Chao   +6 more
core   +1 more source

Simple geometry tribological study of osteochondral graft implantation in the knee [PDF]

, 2017
Robust preclinical test methods involving tribological simulations are required to investigate and understand the tribological function of osteochondral repair interventions in natural knee tissues. The aim of this study was to investigate the effects of
Bobrowitsch E, Custers RJH, Eileen Ingham, Gleghorn JP, Hangody L, Hayashi R, Jakob RP, John Fisher, Katta J, Lane J, Li F, Lima E, Louise M Jennings, McCann L, McCann L, Morita Y, Nakagawa Y, Northwood E, Philippa Bowland, Plainfosse M, Whitney GA   +20 more
core   +1 more source

Inflammation-related pathways involved in damaged articular cartilage of rats exposed to T-2 toxin based on RNA-sequencing analysis

, 2022
Longyan Shi, Qiuliang Liu, Heying Yang, Qi Wang, Jiaxiang Wang, Yingzhong Fan   +5 more
openalex   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

Acetabular osteoid osteoma treated by percutaneous radiofrequency ablation: delayed articular cartilage damage.

The Belgian Journal of Radiology, 2010
The authors report the case of an osteoid osteoma of the acetabular roof in a 17-year-old sportsgirl successfully treated by radiofrequency ablation, with a mid-term evidence of cartilage loss.
P. Bosschaert, F. Deprez
semanticscholar   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source