Results 321 to 330 of about 139,262 (370)

SERUM MARKERS OF ARTICULAR CARTILAGE DAMAGE AND REPAIR

Rheumatic Disease Clinics of North America, 1999
Joint cartilage is a dynamic tissue that reacts to trauma, inflammation, and other insults by attempting to repair its matrix. This reaction results in the release of cartilage macromolecules into the body fluids. Analysis of these fluids has identified a limited number of at least somewhat tissue-specific markers of altered cartilage metabolism ...
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Tribological Assessment of Hydrogels for Replacing Damaged Articular Cartilage

2021
In joint disorders, lesions may be limited to the joint surface. In such cases, replacing only the affected surface to preserve healthy tissue and cancellous bone is preferable to total joint arthroplasty. By employing a cartilage replacement material in focal defect repair or hemiarthroplasty applications, joint stability may be preserved while ...
Doruk Baykal, Steven M. Kurtz
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The Pathophysiology of Damage to Articular Cartilage

1976
In discussing the pathophysiology of damage to articular cartilage in the knee joint, we shall consider the etiologic factors and pathogenetic mechanisms that can account for damage to a joint surface with a previously healthy bony base and cartilaginous covering.
H. Cotta, W. Puhl
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Ultrasonic damage assessment of articular cartilage for ultrasonic drug delivery

2013 IEEE International Ultrasonics Symposium (IUS), 2013
Osteoarthritis (OA) is a common musculoskeletal disease. There are drug therapies under development, but no localized way to transfer drugs into articular cartilage (AC). Previously we showed that 20 kHz high intensity ultrasound (HIU) can deliver micro- and nano-particles into AC [1]. However, at low frequencies, cavitation may occur.
C. Fridlund, V. Kananen, H. J. Nieminen, E. Haeggstrom   +3 more
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Immature articular cartilage is more susceptible to blood‐induced damage than mature articular cartilage: An in vivo animal study

Arthritis & Rheumatism, 2003
AbstractObjectiveCartilage of young but skeletally mature dogs is more susceptible to blood‐induced damage than that of old dogs. The aim of the present study was to investigate whether cartilage of skeletally immature individuals is even more adversely affected by exposure to blood than that of mature individuals, as suggested by clinical practice ...
Michel J J, Hooiveld, Goris, Roosendaal, Marieke E, Vianen, H Marijke, van den Berg, Johannes W J, Bijlsma, Floris P J G, Lafeber   +5 more
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Chondrocyte membrane–coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis

Science Translational Medicine
Osteoarthritis (OA) is a chronic joint disease characterized by progressive degeneration of articular cartilage. A challenge in the development of disease-modifying drugs is effective delivery to chondrocytes.
Ronghui Deng, Ruifang Zhao, Zining Zhang, Yang Chen, Meng Yang, Yixuan Lin, Jing Ye, Nan Li, Hao Qin, Xin Yan, Jian Shi, Fuzhen Yuan, Shitang Song, Zijie Xu, Yi-Fan Song, Jiangnan Fu, Bing-Bing Xu, Gungjun Nie, Jiakuo Yu   +18 more
semanticscholar   +1 more source

Peptide-Based Hydrogel Scaffold Facilitates Articular Cartilage Damage Repair

ACS Applied Materials & Interfaces
Articular cartilage injury is a common disease in clinical medicine. Because of its special physiological structure and lack of blood, lymph, and nerves, its ability to regenerate once damaged is very limited. In this study, we designed and synthesized a series of self- and coassembled cartilage-inducing functional peptide molecules and constructed a ...
Changsheng Chen, Deguang Wu, Zhen Wang, Lanlan Liu, Jinmei He, Jian Li, Bin Chu, Song Wang, Bo Yu, Weiqiang Liu   +9 more
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THE ROLE OF NITRIC OXIDE IN ARTICULAR CARTILAGE DAMAGE

Rheumatic Disease Clinics of North America, 1999
The production of large amounts of NO in vitro by cytokine-activated chondrocytes has been established. In vitro studies suggest that NO compromises chondrocyte survival. The role of NO in regulating matrix biosynthesis and degradation has received much attention. Most studies indicate that NO is at least partly responsible for IL-1-induced suppression
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Patellofemoral articular cartilage damage is associated with poorer patient-reported outcomes following isolated medial patellofemoral ligament reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, 2022
R. C. González, David Ryskamp, S. Swinehart, Parker A. Cavendish, Eric M Milliron, Alex C. Dibartola, Robert A. Duerr, D. Flanigan, R. Magnussen   +8 more
semanticscholar   +1 more source

Piroxicam and poststeroidal damage of articular cartilage.

Roczniki Akademii Medycznej w Bialymstoku (1995), 1996
The experiment was carried out in five groups of rats with 12 animals in each one. In three groups articular cartilage osteoarthrosis like damage was accomplished by intramuscular injection of Dexamethason once per week. The rest of animals with exception of the controls were given Piroxicam each day by gastric tube. In the group of rats receiving only
B, Lewandowski, K, Bernacka, B, Cylwik, D, Duda, P A, Klimiuk   +4 more
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