Results 111 to 120 of about 650,432 (282)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
La articulación de le expresión escrita. The articulation of written expression [PDF]
Ocnos, 2014 En este trabajo se aportan argumentos lingüísticos a favor de la autonomía funcional de la expresión escrita. Esta presentaría una estructuración independiente de la oralidad que, sin embargo, descansaría sobre los mismos principios básicos, estando ...
Jose Henrique Pérez-Rodríguez
doaj
Enhancing the Effectiveness of Social Dialogue Articulation in Europe (EESDA) Project No. VS/2017/0434 Comparative policy recommendations on improving social dialogue articulation and effectiveness in Europe [PDF]
, 2019 The history of European social dialogue dates back to the mid-1980s with the Val Duchesse social dialogue initiative by the European Commission. The aim then was to involve social partners in the internal market process.
Akgüç, Mehtap, Baiocco, Sara
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Articulation Defects in Autistics Children’s Speech
آداب الكوفةThe problem of autism is wide spreading nowadays all over the world. The paper has tackled one of the main problems of autistic children that is poor pronunciation.
احسان المسلماوي
doaj +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
2-Vertex Connectivity in Directed Graphs
, 2015 We complement our study of 2-connectivity in directed graphs, by considering the computation of the following 2-vertex-connectivity relations: We say that two vertices v and w are 2-vertex-connected if there are two internally vertex-disjoint paths from ...
AL Buchsbaum +6 more
core +1 more source
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Fighting Fire with Fire: Technology in Child Sex Trafficking [PDF]
, 2014 We map real articulation data for five Swedish phonemen sequences onto parameters of a biomechanical tongue model that produces movement and muscle activations from position data. The movement produced is broadly correct and could likely be improved by a
Leary, Mary Graw
core +1 more source