Results 51 to 60 of about 585,749 (296)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Effects of stacking fault energies on the interaction between an edge dislocation and an 8.0-nm-diameter Frank loop of self-interstitial atoms

Nuclear Materials and Energy, 2016
Molecular dynamics simulations were conducted to investigate the effects of stacking fault energy (SFE) as a single variable parameter on the interaction between an edge dislocation and a Frank loop of self-interstitial atoms with a diameter of 8.0nm ...
S. Hayakawa, Y. Hayashi, T. Okita, M. Itakura, K. Suzuki, Y. Kuriyama   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Artifact reduction in multichannel pervasive EEG using hybrid WPT-ICA and WPT-EMD signal decomposition techniques [PDF]

, 2014
In order to reduce the muscle artifacts in multi-channel pervasive Electroencephalogram (EEG) signals, we here propose and compare two hybrid algorithms by combining the concept of wavelet packet transform (WPT), empirical mode decomposition (EMD) and ...
Koushik Maharatna, Das, Saptarshi, Saptarshi Das, Maharatna, Koushik, Valentina Bono, Bono, Valentina, Wasifa Jamal, Jamal, Wasifa   +7 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Detection and Differentiation of Focal Intracranial Calcifications and Chronic Microbleeds Using MRI [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Differentiating calcification from chronic microbleeds on imaging may have important clinical implications. Aim: The present study aimed to evaluate the role and relative advantages of Magnetic Resonance Imaging (MRI) in the detection ...
Rajiv Azad, Priyanka Mittal, Ankur Malhotra, Sharad Gangrade   +3 more
doaj   +1 more source

Behavioral Artifacts: What is an Artifact? Or Who Does It?

Artifact, 2007
Abstract The word “artifact” comes from two Latin words. The first, “arte”, means “by skill”, from “ars”, skill. The second, “factum”, is the past participle of “facere”, to do or to make.The word dates back to the early 1800s, meaning “something created by humans usually for a practical purpose; especially: an object remaining from a ...
openaire   +4 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Influence of High Pass Filter Settings on Motor Evoked Potentials

Frontiers in Neuroscience, 2021
ObjectiveMotor evoked potentials (MEP), obtained by transcranial magnetic stimulation (TMS) are a common tool in clinical research and diagnostic. Nevertheless, reports regarding the influence of filter settings on MEP are sparse.
Petyo Nikolov, Petyo Nikolov, Shady S. Hassan, Shady S. Hassan, Alfons Schnitzler, Alfons Schnitzler, Stefan J. Groiss, Stefan J. Groiss   +7 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source