Results 51 to 60 of about 495,691 (314)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Detection and Differentiation of Focal Intracranial Calcifications and Chronic Microbleeds Using MRI [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Differentiating calcification from chronic microbleeds on imaging may have important clinical implications. Aim: The present study aimed to evaluate the role and relative advantages of Magnetic Resonance Imaging (MRI) in the detection ...
Rajiv Azad, Priyanka Mittal, Ankur Malhotra, Sharad Gangrade   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Influence of High Pass Filter Settings on Motor Evoked Potentials

Frontiers in Neuroscience, 2021
ObjectiveMotor evoked potentials (MEP), obtained by transcranial magnetic stimulation (TMS) are a common tool in clinical research and diagnostic. Nevertheless, reports regarding the influence of filter settings on MEP are sparse.
Petyo Nikolov, Petyo Nikolov, Shady S. Hassan, Shady S. Hassan, Alfons Schnitzler, Alfons Schnitzler, Stefan J. Groiss, Stefan J. Groiss   +7 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Brain Extraction From Brain MRI Images Based on Wasserstein GAN and O-Net

IEEE Access, 2021
Brain extraction is an essential pre-processing step for neuroimaging analysis. It is difficult to achieve high-precision extraction from low-quality brain MRI images with artifacts and gray inconsistencies which often result in irregular hole regions in
Shaofeng Jiang, Lanting Guo, Guangbin Cheng, Xingyan Chen, Congxuan Zhang, Zhen Chen   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The Nature of Artifacts [PDF]

, 2002
The modern world is an artificial world, a world of artifacts, but modern science is a science of nature. In this book we explore Herbert Simon's idea of a science of artifacts, of artificial science. In natural science we want to find out what the world
Beckman, Svante
core  

In Situ Testing and Finite Element Analysis of a Discontinuous Mortise and Tenon Stone Bridge Under Natural Excitation

Buildings
To study the dynamic response of multi-span mortise and tenon stone bridges under natural excitation, a bluestone multi-span stone bridge with a main span of 2.56 m in southern China was taken as the research object.
Jiaxing Hu, Shilong Wang, Ming Sun, Ji Zhou   +3 more
doaj   +1 more source

Mobile Forensics Analysis for Instant Messaging Applications Namely TamTam and Botim [PDF]

مجلة جامعة النجاح للأبحاث العلوم الطبيعية
Cybercrimes are rapidly increasing in parallel with the usage of digital tools. Criminals can use many methods to carry out their crimes such as mobile phones and instant messaging applications. Because of that, it is important to investigate the ability
Alsharif H. Aburbeian, Majdi Owda, Amani Y. Owda   +2 more
doaj   +1 more source