Results 41 to 50 of about 492,817 (314)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

How to arrange the robotic environment? Leveraging experience in both motion planning and environment optimization

Frontiers in Robotics and AI
This study presents an experience-based hierarchical-structure optimization algorithm to address the robotic system environment design problem, which combines motion planning and environment arrangement problems together.
Jiaxi Lu, Ryota Takamido, Yusheng Wang, Jun Ota   +3 more
doaj   +1 more source

Effects of stacking fault energies on the interaction between an edge dislocation and an 8.0-nm-diameter Frank loop of self-interstitial atoms

Nuclear Materials and Energy, 2016
Molecular dynamics simulations were conducted to investigate the effects of stacking fault energy (SFE) as a single variable parameter on the interaction between an edge dislocation and a Frank loop of self-interstitial atoms with a diameter of 8.0nm ...
S. Hayakawa, Y. Hayashi, T. Okita, M. Itakura, K. Suzuki, Y. Kuriyama   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Action Recognition and Subsequent In-Depth Analysis for Improving the Time Efficiency of Bimanual Industrial Work

IEEE Access
Although there are numerous studies that have developed human action recognition (HAR) algorithms, they have mostly focused on accurate recognition of actions; there is a lack of knowledge on analysis and interpretation of the recognition results for ...
Ryota Takamido, Jun Ota
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

kshitij-v-mehta/SC20-NVMe-Paper-Artifacts: Artifacts for the SC20 Paper

, 2020
All artifacts created for the Supercomputing 2020 paper "Co-design Evaluation of HPC I/O Middleware forMulti-Tier Storage ...
Kshitij Mehta
core   +1 more source

Study of design factors for transfer-aid equipment based on caregivers’ feelings

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
To avoid back injuries, caregivers are advised to use transfer-aid equipment while transferring a patient from a bed to a wheelchair. Although the usage of such equipment has been recommended for several decades, it remains unpopular in several countries,
Shouhei SHIRAFUJI, Taiki OGATA, Zhifeng HUANG, Naotaka MATSUI, Takeji UEDA, Jukai MAEDA, Yasuko KITAJIMA, Masako KANAI-PAK, Yasushi UMEDA, Hideyoshi YANAGISAWA, Jun OTA   +10 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Detection and Differentiation of Focal Intracranial Calcifications and Chronic Microbleeds Using MRI [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Differentiating calcification from chronic microbleeds on imaging may have important clinical implications. Aim: The present study aimed to evaluate the role and relative advantages of Magnetic Resonance Imaging (MRI) in the detection ...
Rajiv Azad, Priyanka Mittal, Ankur Malhotra, Sharad Gangrade   +3 more
doaj   +1 more source