Results 61 to 70 of about 492,817 (314)

Designing, Producing and Using Artifacts in the Structuration of Firm Knowledge: Evidence from Proprietary and Open Processes of Software Development. [PDF]

In the paper we study the recursive nature of artifacts in the production and the socialization of organizational knowledge. In this respect, artifacts are interpreted both as the product (output) of organizational knowledge processes and, at the same ...
Alessandro Rossi, Marco Zamarian
core   +2 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Dynamic Characteristics Analysis and Finite Element Simulation of an Ancient Timber Building under Environmental Excitation

Buildings
This study investigates the vibration response and dynamic characteristics of the Shigudeng Pavilion under environmental excitation, employing a comprehensive approach that includes vibration response measurements, theoretical analysis, and finite ...
Ji Zhou, Jiaxing Hu, Baijun Zhang, Ming Sun, Shilong Wang   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The IT Artifact and Telecommuting [PDF]

, 2007
Research on the concept of telecommuting or telework, as it is known in various areas of the world, has appeared in information systems (IS) and non-IS publications for more than 20 years. Research areas with respect to telecommuting are quite varied, from Information and Communication Technologies (ICT) use, to transportation, managerial control, work-
France Bélanger, Mary Beth Watson-Manheim, Susan Harrington, Nancy Johnson, Derrick J. Neufeld   +4 more
openaire   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

An evaluation of prospective motion correction (PMC) for high resolution quantitative MRI. [PDF]

, 2015
Quantitative imaging aims to provide in vivo neuroimaging biomarkers with high research and diagnostic value that are sensitive to underlying tissue microstructure.
Weiskopf, N, Weiskopf, N. ; https://orcid.org/, Josephs, O, Oliver Josephs, Herbst, M, Martina F. Callaghan, Zaitsev, M., Weiskopf, Nikolaus, Michael eHerbst, Martina F Callaghan, Nikolaus eWeiskopf, Zaitsev, M, Todd, N., Nick Todd, Herbst, M., Herbst, Michael, Maxim eZaitsev, Nikolaus Weiskopf, Michael Herbst, Callaghan, M., Nick eTodd, Maxim Zaitsev, Josephs, O., Callaghan, Martina F., Todd, Nick, Callaghan, MF, Josephs, Oliver, Todd, N, Oliver eJosephs, Zaitsev, Maxim   +29 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Automatic reconstruction of semantic façade model of architectural heritage

Heritage Science
Façade elements, such as windows, doors, balconies, sculptures, and totems, in architectural heritage images with incomplete structures should be automatically reconstructed for applications in 3D analysis, 3D modeling, virtual tourism, city planning ...
Jingwei Hou, Ji Zhou, Yonghong He, Bo Hou, Jia Li   +4 more
doaj   +1 more source