Results 51 to 60 of about 4,276,769 (250)

Ethics of Artificial Intelligence [PDF]

open access: yes, 2021
Artificial intelligence (AI) is a digital technology that will be of major importance for the development of humanity in the near future. AI has raised fundamental questions about what we should do with such systems, what the systems themselves should do,
Müller, Vincent C.
core  

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Gauge matters: Observing the vortex-nucleation transition in a Bose condensate

open access: yes, 2015
The order parameter of a quantum-coherent many-body system can include a phase degree of freedom, which, in the presence of an electromagnetic field, depends on the choice of gauge. Because of the relationship between the phase gradient and the velocity,
Beeler, M. C.   +5 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

“AI-Eyes Healthcare” – A glimpse into the role of artificial intelligence in healthcare and the possible implications in Indian Scenario [PDF]

open access: yesAl Ameen Journal of Medical Sciences, 2019
Artificial Intelligence (AI) can be described in simplistic terms as “Thinking Machines, a term first coined by one of the founding Fathers of Artificial Intelligence, Prof John McCarthy, nearly 63 years ago [1].
Akshay Jadhav, P.T. Jadhav
doaj  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Observation of Light Guiding by Artificial Gauge Fields

open access: yes, 2018
The use of artificial gauge fields enables systems of uncharged particles to behave as if affected by external fields. Generated by geometry or external modulation, artificial gauge fields have been instrumental in demonstrating topological phenomena in ...
Bandres, Miguel A.   +6 more
core   +1 more source

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