Results 81 to 90 of about 9,399 (221)

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

Cardiomyocyte and stromal cell cross-talk influences the pathogenesis of arrhythmogenic cardiomyopathy: a multi-level analysis uncovers DLK1-NOTCH pathway role in fibro-adipose remodelling

Cell Death Discovery
Arrhythmogenic Cardiomyopathy (ACM) is a life-threatening, genetically determined disease primarily caused by mutations in desmosomal genes, such as PKP2.
Angela Serena Maione, Lara Iengo, Luca Sala, Ilaria Massaiu, Mattia Chiesa, Melania Lippi, Stefania Ghilardi, Chiara Florindi, Francesco Lodola, Antonio Zaza, Claudio Tondo, Marco Schiavone, Cristina Banfi, Giulio Pompilio, Paolo Poggio, Elena Sommariva   +15 more
doaj   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Perspectives on novel therapeutic strategies for right heart failure in pulmonary arterial hypertension: lessons from the left heart

European Respiratory Review, 2010
Right heart function is the main determinant of prognosis in pulmonary arterial hypertension (PAH). At present, no treatments are currently available that directly target the right ventricle, as we will demonstrate in this article.
M. L. Handoko, F. S. de Man, C. P. Allaart, W. J. Paulus, N. Westerhof, A. Vonk-Noordegraaf   +5 more
doaj  

Advanced imaging and multi‐omics to characterize cardiomyocyte ageing and its electrocardiographic imprint in PKP2 arrhythmogenic cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend We used a murine model of cardiomyocyte‐specific conditional knockout of plakophilin 2 (PKP2cKO, middle panel). Using advanced imaging technology, we unveiled distinct hallmarks of premature ageing in PKP2cKO cardiomyocytes, including DNA damage and loss of repressed heterochromatin at the nuclear periphery, and mitochondrial ...
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito, Xianming Lin, Marina Cerrone, Joanna Abi Rizk, Michael Cammer, Yan Deng, Joseph Sall, Mingliang Zhang, Feng‐Xia Liang, Irene de Lázaro, Mario Delmar   +12 more
wiley   +1 more source

Comorbid anxiety disorders and quality of life in patients with an artificial cardiac pacemaker

Терапевтический архив, 2011
Aim. To investigate correlations between anxiety disorders, quality of life (QoL)and patient's age, mode, duration and course of cardiac pacing(CP). Material and methods.
Bakhram Guseynovich Iskenderov, Elena Vladimirovna Petrova, Dmitriy Borisovich Maksimov, Oksana Aleksandrovna Kameneva, B G Iskenderov, E V Petrova, D B Maximov, O A Kameneva   +7 more
doaj  

Kinematic‐calcium loops unravel impaired excitation–contraction coupling in MELAS‐affected cardioids

The Journal of Physiology, EarlyView.
Abstract figure legend Representation of kinematic and calcium transient loop with respect to traditional time coplotting. Abstract Impaired Ca2+ handling, and in particular leakage from the sarcoplasmic reticulum, is a critical mechanism in metabolic diseases affecting the heart.
Margherita Burattini, Annalinda Pisano, Maria Gemma Pignataro, Giulia d'Amati, Silvana Pinelli, Minh Long Hoang, Francesco Paolo Lo Muzio, Michele Miragoli   +7 more
wiley   +1 more source

Dyssynchrony without dysfunction: Left bundle branch block does not acutely reduce cardiac output

The Journal of Physiology, EarlyView.
Abstract figure legend Six electromechanical in silico heart models were simulated under healthy and pure acute left bundle branch block (LBBB) conditions. LBBB induced electrical dyssynchrony and increased left ventricular free wall strain, while the right and left ventricular ejection fraction remained relatively unchanged.
Carola Kruthoff, Jonathan Krauß, Jorge Sánchez, Tobias Gerach, Cristian Barrios Espinosa, Jan‐Erik Duhme, Axel Loewe   +6 more
wiley   +1 more source

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source