Activation of spleen tyrosine kinase (Syk) at fertilization in Rhinella arenarum eggs [PDF]
, 2014 Recently, we have provided evidence for the involvement of a cytosolic tyrosine–phosphorylatable 70 kDa oocyte protein in Rhinella arenarum (Anura: Bufonidae) fertilization.
Coux, Gabriela +1 more
core +1 more source
TRPV3 Channels Mediate Strontium-Induced Mouse-Egg Activation
Cell Reports, 2013 In mammals, calcium influx is required for oocyte maturation and egg activation. The molecular identities of the calcium-permeant channels that underlie the initiation of embryonic development are not established.
Ingrid Carvacho +3 more
doaj +1 more source
Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos [PDF]
, 2016 Despite ongoing research in a number of species, the efficiency of embryo production by nuclear transfer remains low. Incomplete epigenetic reprogramming of the nucleus introduced in the recipient oocyte is one factor proposed to limit the success of ...
Beaujean, Nathalie +5 more
core +3 more sources
Efficacy of Calcium Chloride Dihydrate Supplementation at ICSI on Patient Outcomes
Fertility & Reproduction, 2022 Background: ICSI typically results in fertilisation rates of >65% however patients may still have low or no fertilisation despite the oocyte and sperm quality appearing normal.
Sophie POPKISS +4 more
doaj +1 more source
Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components [PDF]
, 1990 An M-phase-specific histone H1 kinase (H1K) has been described in a wide variety of eukaryotic cell types undergoing the G2/M transition in the cell division cycle.
Beach, D., Meijer, L., Pondaven, P.
core +1 more source
The MinK Potassium Channel Exists in Functional and Nonfunctional Forms When Expressed in the Plasma Membrane of \u3cem\u3eXenopus\u3c/em\u3e Oocytes [PDF]
, 1994 The minK protein induces a slowly activating voltage-dependent potassium current when expressed in Xenopus oocytes. In order to measure the levels of minK protein in the plasma membrane, we have modified the minK gene by inserting a 9 amino acid epitope ...
Blumenthal, Edward M +1 more
core +1 more source
Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
Advanced Science, EarlyView.This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
wiley +1 more source
Reproductive Biology and Endocrinology, 2022 Globozoospermia (OMIM: 102530) is a rare type of teratozoospermia ( A; p.R1224Q) in the patient. This variant significantly reduced the protein expression of SSFA2.
Gelin Huang +11 more
doaj +1 more source
Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis [PDF]
, 2010 Meiosis is unique to germ cells and essential for reproduction. During the first meiotic division, homologous chromosomes pair, recombine, and form chiasmata.
Choi, Y +8 more
core +5 more sources
Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development
Advanced Science, EarlyView.The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu +12 more
wiley +1 more source