Results 151 to 160 of about 1,890,030 (376)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

open access: yesAdvanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi   +10 more
wiley   +1 more source

Overnight extubation and risk of extubation failure in patients in the pediatric intensive care unit: an exploratory review

open access: yesFrontiers in Pediatrics
Background/objectivesExtubation in pediatric intensive care units (PICUs) requires care and thoroughness to minimize risks of extubation failure, systemic complications, and mortality.
Harold Andrés Payán-Salcedo   +7 more
doaj   +1 more source

A Resistive Soft Robotic Exosuit for Dynamic Body Loading in Hypogravity

open access: yesAdvanced Science, EarlyView.
The resistive hypogravity exosuit is a lightweight wearable robotic exosuit that uses pneumatic artificial muscles to restore Earth‐like metabolic and muscular demands during locomotion in low gravity. Tested on healthy subjects in Earth and simulated Moon gravity, the suit restores energy expenditure and muscle activation without altering gait ...
Emanuele Pulvirenti   +6 more
wiley   +1 more source

Evaluation of human obstructive sleep apnea using computational fluid dynamics. [PDF]

open access: yes, 2019
Obstructive sleep apnea (OSA) severity might be correlated to the flow characteristics of the upper airways. We aimed to investigate the severity of OSA based on 3D models constructed from CT scans coupled with computational fluid dynamics (CFD ...
Jafari, Behrouz   +4 more
core  

BIPAP protocol usage in patients admitted to the Internal Medicine unit

open access: yesNURE Investigación, 2013
The use of noninvasive mechanical ventilation equipment becomes more common in internal medicine units. Due to its indications, such as severe respiratory failure, or hypoxemic respiratory failure, it means a great help in these units.
Óscar Bautista Villaécija   +1 more
doaj  

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

open access: yesAdvanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun   +12 more
wiley   +1 more source

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