Results 111 to 120 of about 73,779 (261)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Nambu monopoles interacting with lattice defects in two-dimensional artificial square spin ice

, 2013
The interactions between an excitation (similar to a pair of Nambu monopoles) and a lattice defect are studied in an artificial two-dimensional square spin ice.
A. R. Pereira, G. M. Wysin, H. Zabel, L. A. S. Mól, R. C. Silva, R. J. C. Lopes, W. A. Moura-Melo   +6 more
core   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

Dynamics of artificial spin ice: a continuous honeycomb network

New Journal of Physics, 2012
19 pages, focus issue of New J. Phys.
Shen, Yichen, Petrova, Olga, Mellado, Paula, Daunheimer, Stephen, Cumings, John, Tchernyshyov, Oleg   +5 more
openaire   +4 more sources

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Diversity enabling equilibration: disorder and the ground state in artificial spin ice

, 2011
We report a novel approach to the question of whether and how the ground state can be achieved in square artificial spin ices where frustration is incomplete.
Budrikis, Zoe, Politi, Paolo, Stamps, R. L.   +2 more
core   +1 more source

Dendritic Nano‐Based Slippery Coating by Synergistic Mechanical and Electrostatic Interactions with Persistent and Exceptional Combats Thrombosis

Advanced Science, EarlyView.
A novel dendritic nano‐based slippery coating (DNSC), fabricated by encapsulating carboxyl silicone oil within amino dendritic silica nanoparticles and co‐embedding them in an epoxy resin matrix. The dendritic architecture enhances nanoparticle dispersion in the matrix and establishes mechanical interlock.
Shu Zhang, Yao Shen, Juan Liu, Qing Zeng, Yunze Ma, Shuping Chen, Taiyu Nan, Xiaoying Qiu, Jiayi Yu, Tao Fan, Guozhi Huang, Jihua Zou, Chengduan Yang   +12 more
wiley   +1 more source

Stochastic hexagonal injectors in artificial spin ice

Communications Materials
Artificial spin ice (ASI) systems have emerged as powerful platforms for exploring the fundamental aspects of magnetic frustration and topological phenomena in condensed matter physics. In this study, we investigate the bountiful effects that result from
Robert Puttock, Anaïs Fondet, Ingrid M. Andersen, Mark C. Rosamond, Alexander Fernández Scarioni, Hans W. Schumacher, Etienne Snoeck, Christophe Gatel, Olga Kazakova   +8 more
doaj   +1 more source

Magnetic order and energy-scale hierarchy in artificial spin ice

, 2018
In order to explain and predict the properties of many physical systems, it is essential to understand the interplay of different energy-scales. Here we present investigations of the magnetic order in thermalised artificial spin ice structures, with ...
Arnalds, Unnar B., Chioar, Ioan-Augustin, Greving, David, Hase, Thomas P. A., Hjörvarsson, Björgvin, Kapaklis, Vassilios, Stein, Aaron, Stopfel, Henry, Östman, Erik   +8 more
core   +1 more source

Breaking the Toughness‐Stretchability Trade‐Off in Hydrogels with Dynamic Hydrogen Bonding

Advanced Science, EarlyView.
A novel nanocomposite hydrogel architecture overcomes the inherent conflict between toughness and stretchability by integrating uniformly dispersed aminopropyl‐hybrid‐phyllosilicate nanosheets within a polyacrylamide matrix. This design leverages a dynamic hydrogen‐bonding network to facilitate efficient energy dissipation and self‐recovery.
Yining Gao, Yong Tao, Roland J.‐M. Pellenq, Fazhou Wang   +3 more
wiley   +1 more source