Results 21 to 30 of about 139,371 (207)

HENOS: A Henon Map-Based Chaotic Oversampling Strategy for Imbalanced Data Classification

IEEE Access
The effectiveness of machine learning models is profoundly influenced by the quality and distribution of training data. However, real-world datasets are often highly imbalanced, where conventional classification algorithms tend to favor the majority ...
Bahaeddin Turkoglu, Muhammed Abdulhamid Karabiyik, Tunc Asuroglu   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Source of Lake Wobegon

Nonpartisan Education Review, 2005
John J. Cannell's late 1980's “Lake Wobegon” reports suggested widespread deliberate educator manipulation of norm-referenced standardized test (NRT) administrations and results, resulting in artificial test score gains.
Richard P. Phelps
doaj  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The Source of Lake Wobegon (slide show)

Nonpartisan Education Review, 2007
John J. Cannell's late 1980's "Lake Wobegon" reports suggested widespread deliberate educator manipulation of norm-referenced standardized test (NRT) administrations and results, resulting in artificial test score gains.
Richard P. Phelps
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Further Comment on "'Lake Woebegone,' Twenty Years Later"

Nonpartisan Education Review, 2006
no ...
Richard P. Phelps
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

“Lake Woebegone,” Twenty Years Later

Nonpartisan Education Review, 2006
Twenty years ago, John Cannell developed data on test scores that became known as the “Lake Woebegone effect.” This commentary describes that experience.
John Jacob Cannell, M.D.
doaj  

Optimizing expected word error rate via sampling for speech recognition

, 2017
State-level minimum Bayes risk (sMBR) training has become the de facto standard for sequence-level training of speech recognition acoustic models. It has an elegant formulation using the expectation semiring, and gives large improvements in word error ...
Shannon, Matt
core   +1 more source