Results 71 to 80 of about 22,237 (159)

Longitudinal Serum Uric Acid Variation and Risk of Major Adverse Cardiovascular Events and Mortality: A Systematic Review and Meta‐Analysis

Clinical Cardiology, Volume 49, Issue 9, September 2026.
A systematic review and meta‐analysis of six cohort studies (160 640 participants) demonstrated that greater longitudinal serum uric acid variability was independently associated with increased risks of all‐cause mortality, cardiovascular disease, cardiovascular mortality, and heart failure‐related outcomes.
Saima Nisar, Asif Shah, Abida Perveen
wiley   +1 more source

Have We Met Before? Findings on HIV Retesting in Routine Healthcare Settings, Using Eswatini HIV‐1 Recent Infection Surveillance Data

Journal of the International AIDS Society, Volume 29, Issue 9, September 2026.
ABSTRACT Introduction Eswatini is rapidly approaching the conditions needed to achieve and sustain HIV epidemic control. Repeating diagnostic testing of people living with HIV (PLHIV) already on antiretroviral therapy (ART) is not typically indicated, can lead to misidentification of new HIV diagnoses and distorts estimates of progress towards epidemic
Claire C. Steiner, Eugenie A. Poirot, Samkelo Simelane, Dumile Sibandze, Lenhle Dube, Vusie Lokotfwako, Jessica Justman, Kathryn Lupoli, Trudy Dobbs, Munyaradzi Pasipamire, Cebisile Ngcamphalala, Ruben Sahabo, Harriet Nuwagaba‐Biribonwoha, Suzue Saito   +13 more
wiley   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

Wnt14 regulates the cellular inflammation induced by avian reovirus and interacts with the viral σB protein

Poultry Science
Avian reovirus (ARV) typically induces viral arthritis or tenosynovitis in chickens. The ARV structural protein σB plays a crucial role in viral replication and regulates cellular signaling pathways through interactions with host proteins. In this study,
Chengcheng Zhang, Huimin Wu, Ting Li, Jianqiang Wu, Xiaorong Zhang, Yantao Wu   +5 more
doaj   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Design, Synthesis, Biological Studies and Putative Binding Mode of Novel Benzotriazolothalidomide Derivatives as Cereblon Ligands

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
We narrated the identification of benzotriazole‐based cereblon ligands for their potential use either in PROTAC or CELMoD chemical space, through systematic design and SAR studies, synthesis, biological, and docking experiments resulting in a non‐cytotoxic, potent, drug‐like compound 13, offering scope for optimization to yield an in vivo efficacious ...
Pramit Ganguly, Mrinalkanti Kundu, Tonmoy Sarkar, Gillian Dcosta, Kankana Banerjee, Ritama Banerjee, Arun K. Hajra, Sk Sahabuddin, Sohini Basu, Avratanu Das, Suparna Das, Rajib Barik, Md Ashif Ali   +12 more
wiley   +1 more source

Automated Alignment of Math Items to Content Standards in Large‐Scale Assessments Using Language Models

Educational Measurement: Issues and Practice, Volume 45, Issue 3, Fall 2026.
Abstract Accurate alignment of items to content standards is critical for valid score interpretation in large‐scale assessments. This study evaluates three automated paradigms for aligning Math items with four domain labels and nineteen skill labels.
Qingshu Xu, Hong Jiao, Tianyi Zhou, Ming Li, Nan Zhang, Sydney Peters, Yanbin Fu   +6 more
wiley   +1 more source

Assessment of Immunological Interference Between Live Infectious Bursal Disease Virus and Avian Reovirus Vaccines in SPF Chickens

Animals
Infectious bursal disease virus (IBDV) and avian reovirus (ARV) are major immunosuppressive pathogens controlled through the widespread use of live attenuated vaccines.
Jiaolong Wen, Mingwei Li, Yuecheng Long, Shenghua Yang, Chuang Lyu, Junxian Li, Guanming Huo, Ermin Xie, Yiming Liu, Yanhua Xu, Xuesong Li, Jianping Qin, Lijuan Yin, Wencheng Lin   +13 more
doaj   +1 more source