Results 81 to 90 of about 134,090 (205)

East African HIV care: depression and HIV outcomes. [PDF]

, 2019
Importance:Depression is a common co-morbidity for people living with HIV (PLWH) and is associated with elevated plasma HIV RNA levels. While depression correlates with deficits in antiretroviral (ARV) adherence, little data exist to inform the ...
Adamu, Y, Ake, JA, Kiweewa, F, Maganga, L, Maswai, J, McCulloch, CE, Meffert, SM, Neylan, TC, Owuoth, J, Polyak, CS, Valcour, VG   +10 more
core  

Characterization of VRC01, a potent and broadly neutralizing anti-HIV mAb, produced in transiently and stably transformed tobacco [PDF]

, 2014
The proposed clinical trial in Africa of VRC01, a potent broadly neutralizing antibody (bNAb) capable of neutralizing 91% of known HIV-1 isolates, raises concerns about testing a treatment which will be too expensive to be accessible by the most ...
EMEA, Montefiori D.C., Pabst M., Pegu A., WHO   +4 more
core   +1 more source

Informal PrEP use in Greece: The long, hard road to formal programmatic implementation

HIV Medicine, Volume 27, Issue 2, Page 310-315, February 2026.
Abstract Objectives Pre‐exposure prophylaxis (PrEP) with antiretroviral drugs (ARVs) is a highly effective HIV prevention strategy. Although the European Medicines Agency approved oral PrEP in 2016 and the World Health Organization (WHO) has since recommended simplified and person‐centred delivery models, implementation remains inconsistent across ...
Konstantinos Protopapas, Charalampos D. Moschopoulos, Nikolaos Kalesis, Ioannis Mameletzis   +3 more
wiley   +1 more source

Autophagy induced by avian reovirus enhances viral replication in chickens at the early stage of infection

BMC Veterinary Research, 2019
Background Avian reovirus (ARV) is an important pathogen that can cause serious disease in poultry. Though several in vitro studies revealed some molecular mechanisms that are responsible for ARV-induced autophagy, it is still largely unknown how ARV ...
Xiaosai Niu, Chengcheng Zhang, Yuyang Wang, Mengjiao Guo, Baoyang Ruan, Xuefeng Wang, Tianqi Wu, Xiaorong Zhang, Yantao Wu   +8 more
doaj   +1 more source

Perlukah Promosi Test HIV pada Pasangan Populasi Kunci dan Serodiskordan? [PDF]

, 2015
Situasi perawatan dan pengobatan Anti Retro Viral (ARV) selama ini masih terdapat kesenjangan yang besar antara jumlah ODHA yang mengetahui statusnya, jumlah ODHA yang masuk perawatan HIV meskipun memenuhi syarat untuk mengikuti terapi, jumlah ODHA yang ...
Harjanti, K. A. (Kekek), Widihastuti, A. (Asti)   +1 more
core  

Gezielte Modulation des spliceosomalen Proteins USP39 durch allosterische Liganden und PROTAC‐induzierte Degradation

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Socio - demographic characteristics of HIV patients diagnosed at immunization centres in Calabar, South – south, Calabar, Nigeria

Nigerian Journal of Paediatrics, 2016
Introduction: The World Health Organization (WHO) estimated that 3.2 million children were living with Human Immunodeficiency Virus (HIV) at the end of 2013, mostly in sub- Saharan Africa.
Venn I , Venn I, Ochigbo S , Anah M, Asindi A   +4 more
doaj  

Construction of recombinant Marek’s disease virus co-expressing σB and σC of avian reoviruses

Frontiers in Veterinary Science
Avian reoviruses (ARVs) cause viral arthritis or tenosynovitis, resulting in poor weight gain and increased feed conversion ratios in chickens. In this study, we generated three Marek’s disease virus (MDV) recombinants, namely, rMDV-ARV-σB, rMDV-ARV-σC ...
Li Gao, Li Gao, Li Zhong, Yongzhen Liu, Changjun Liu, Yanping Zhang, Hongyu Cui, Xiaole Qi, Jiayong Zhang, Jia Xu, Suyan Wang, Yuntong Chen, Yulu Duan, Kai Li, Kai Li, Kai Li, Yulong Gao, Xiaomei Wang, Xiaomei Wang   +18 more
doaj   +1 more source

A dynamic Bayesian nonlinear mixed-effects model of HIV response incorporating medication adherence, drug resistance and covariates

, 2011
HIV dynamic studies have contributed significantly to the understanding of HIV pathogenesis and antiviral treatment strategies for AIDS patients. Establishing the relationship of virologic responses with clinical factors and covariates during long-term ...
Acosta, Edward P., Holden-Wiltse, Jeanne, Huang, Yangxin, Wu, Hulin   +3 more
core   +1 more source

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source