Results 1 to 10 of about 69 (69)

Mouse Epidermal Aryl Hydrocarbon Hydroxylase

Journal of Investigative Dermatology, 1976
Mouse skin contains a NADPH-dependent, aryl hydrocarbon hydroxylase (AHH), which is inducible by polycyclic aromatic hydrocarbons. In general, unsubstituted polycyclic hydrocarbons caused a greater induction of epidermal AHH than substituted one (1,2,3,4-dibenzanthracene greater than 1,2,5,6-dibenzanthracene greater than benz (a)anthracene equal 3 ...
Sara Thompson, Thomas J. Slaga
openaire   +3 more sources

Human Skin Aryl Hydrocarbon Hydroxylase [PDF]

Journal of Clinical Investigation, 1978
Coal tar products, which are widely used in treating dermatologic disease, contain numerous polycyclic aromatic hydrocarbons, including 3,4-benzo[a]pyrene (BP). BP is among the most potent environmental chemical carcinogens and is known to evoke tumors in the skin of experimental animals and perhaps also of man.
Attallah Kappas, David R. Bickers
openaire   +3 more sources

Omeprazole and aryl hydrocarbon hydroxylases: Should we be worried? [PDF]

Hepatology, 1991
Diaz and colleagues have carefully studied the effects of omeprazole on the expression of cytochrome P-450 in primary cultures of human hepatocytes. When omeprazole was added to the culture medium in varying concentrations, there was an increase in P-450IA2 protein and mRNA concentrations, an increase in de novo synthesis of P-
Kolars, Joseph C., Turgeon, D. K., Watkins, Paul B.   +2 more
openaire   +4 more sources

Origin and characterization of cyclodepsipeptides: Comprehensive structural approaches with focus on mass spectrometry analysis of alkali‐cationized molecular species

Mass Spectrometry Reviews, EarlyView.
Abstract Cyclodepsipeptides (CDPs) represent a huge family of chemically and structurally diverse molecules with a wide ability for molecular interactions. CDPs are cyclic peptide‐related natural products made up of both proteinogenic and nonproteinogenic amino acids linked by amide and ester bonds.
Sophie Liuu, Annelaure Damont, Alain Perret, Olivier Firmesse, François Becher, Gwenaëlle Lavison‐Bompard, Amandine Hueber, Amina S. Woods, Ekaterina Darii, François Fenaille, Jean‐Claude Tabet   +10 more
wiley   +1 more source

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, EarlyView.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF‐dependent activation of hypoxia‐inducible genes

The FEBS Journal, EarlyView.
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, Angeliki Karagiota, George Stamatakis, Martina Samiotaki, George Panayotou, George Simos, Georgia Chachami   +8 more
wiley   +1 more source

Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms

Journal of Pineal Research, Volume 77, Issue 4, July 2025.
ABSTRACT Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast formation, inhibits osteoclast activity, and synchronizes skeletal tissue rhythms to support bone health.
Ko‐Hsiu Lu, Yi‐Hsien Hsieh, Renn‐Chia Lin, Meng‐Ying Tsai, Shun‐Fa Yang   +4 more
wiley   +1 more source

Targeted Lung Premetastasis Niche: Mechanisms, Strategies, and Application

MedComm, Volume 6, Issue 6, June 2025.
Before the cancer cells arrive to the lung through blood vessels, these cancer cells secreted specific factors for two main purposes: first, to recruit bone marrow‐derived cells; and second, to regulate the activation of target cells. Additionally, the unique structure of the lungs provides a comfortable environment. Consequently, the formation of lung
Chenghao Cao, Di Lu, Huigang Li, Shen Pan, Jianyong Zhuo, Zuyuan Lin, Chiyu He, Peiru Zhang, Songmin Ying, Xuyong Wei, Shusen Zheng, Zhe Yang, Xiao Xu   +12 more
wiley   +1 more source

Gut Microbiota and Hepatocellular Carcinoma: Metabolic Products and Immunotherapy Modulation

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background The relationship between hepatocellular carcinoma (HCC) and gut microbiota has gained attention for its impact on HCC immunotherapy. Methods Key gut microbial metabolites, including bile acids, toll‐like receptor 4, short‐chain fatty acids, and bacterial toxins, contribute to HCC progression and influence immune responses through ...
Kunmin Xiao, Kexin Li, Kunlin Xiao, Jinzu Yang, Lei Zhou   +4 more
wiley   +1 more source

The influence of microbiome‐derived amino acids metabolites in shaping the glioma immunosuppressive microenvironment

Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.
Left: The disruption of the balance between carcinogenic bacteria and probiotics mediated by antibiotics, protein, and glucose intake. Middle: The gut microbiota‐derived amino acids, primarily through tryptophan, tyrosine, arginine, and branched‐chain amino acid pathways, regulate glioma development via mechanisms such as AHR activation, metabolic ...
Qianquan Ma, Zhihao Song, Chenlong Yang, Zijin Zhao, Guodong Tang, Jia You, Chong Zeng, Jun Yang, Qing Liu, Haoyu Li, Wei Huang   +10 more
wiley   +1 more source