Results 11 to 20 of about 17,003 (187)

Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study [PDF]

Environmental Health, 2009
BackgroundDioxins and related compounds are suspected of causing neurological disruption. Epidemiological studies indicated that exposure to these compounds caused neurodevelopmental disturbances such as learning disability and attention deficit ...
Eiichi Akahoshi, Seiko Yoshimura, Saeko Uruno, M. Ishihara-Sugano   +3 more
semanticscholar   +2 more sources

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

Journal of Biological Chemistry, 1976
A. Poland, E. Glover, A. Kende
semanticscholar   +2 more sources

Hypoxia-inducible factor (HIF): fuel for cancer progression

, 2021
Hypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly multiplying tumor cells and a lack of proper blood supply.
Aljabali, Alaa A., Bakshi, Hamid A., Charbe, Nitin B., Chellappan, Dinesh Kumar, Dhanjal, Daljeet S., Dua, Kamal, Dureja, Harish, Gupta, Gaurav, Kaur, Harpreet, Khurana, Navneet, Mehta, Meenu, Nammi, Srinivas, Satija, Saurabh, Sharma, Neha, Sharma, Prabal, Singh, Thakur Gurjeet, Tambuwala, Murtaza M., Vyas, Manish, Zacconi, Flavia C   +18 more
core   +2 more sources

Tryptophan promoted β-defensin-2 expression via the mTOR pathway and its metabolites: kynurenine banding to aryl hydrocarbon receptor in rat intestine

RSC Advances, 2020
In this study, we investigated the signalling pathways mediating tryptophan (Trp)-promoted β-defensin-2 (BD-2) expression in rat intestinal mucosa. Sprague Dawley rats were administered with l-Trp and treated with rapamycin (RAPA), 1-methyltryptophan (1 ...
Zhiru Tang, Baoshi Shi, Weizhong Sun, Yulong Yin, Qingju Chen, Taha Mohamed, Changwen Lu, Zhihong Sun   +7 more
semanticscholar   +1 more source

2,3,7,8-Tetrachlorodibenzo-p-dioxin alters steroid secretion but does not affect cell viability and the incidence of apoptosis in porcine luteinised granulosa cells [PDF]

, 2014
The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a by-product of human industrial activity, was found to affect ovarian steroidogenesis in animals, but the mechanism of its action is still unclear. The aims of the study were to examine the effect
Ciereszko, Renata, Jablonska, Olga, Kołomycka, Agnieszka, Nynca, Anna, Piasecka-Srader, Joanna, Robak, Anna, Wąsowska, Barbara   +6 more
core   +1 more source

Catalysts on Demand: Selective Oxidations by Laboratory-Evolved Cytochrome P450 BM3 [PDF]

, 2009
Efficient catalysts for selective oxidation of C-H bonds using atmospheric oxygen are highly desirable to decrease the economic and environmental costs associated with conventional oxidation processes.
Arnold, Frances H., Lewis, Jared C.
core   +2 more sources

An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2 [PDF]

, 2013
BACKGROUND: Aryl hydrocarbon receptor (AhR) not only regulates drug-metabolizing enzyme expression but also regulates cancer malignancy. The steps to the development of malignancy include angiogenesis that is induced by tumor microenvironments, hypoxia ...
Chie Tachikawa, Jun Terashima, Kenzo Kudo, Shogo Ozawa, Wataru Habano   +4 more
core   +1 more source

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source

Cabbage and vitamin E: their effect on colon tumor formation in mice. [PDF]

, 1987
The effects of cabbage and vitamin E on colon carcinogenesis were investigated in Swiss mice treated with 1,2-dimethylhydrazine. Throughout the experiment the mice were fed a laboratory chow diet (46 mg vitamin E per kg) or chow containing 13 g ...
El-Khatib, Shukri M., Temple, Norman J.
core   +1 more source

HIF-2α as a possible therapeutic target of osteoarthritis [PDF]

, 2010
SummaryObjectiveEndochondral ossification, a conversion process from nonvascularized and hypoxic cartilage to highly vascularized bone, plays a crucial role in osteoarthritis (OA) development as well as in physiological skeletal growth.
Kawaguchi, H., Saito, T.
core   +1 more source