Results 41 to 50 of about 17,003 (187)
EFSA Journal, Volume 23, Issue 5, May 2025.Abstract According to the ‘EFSA‐SANTE Action Plan on Cumulative Risk Assessment for pesticides residues’, EFSA initiated a retrospective cumulative risk assessment (CRA) of the effects of pesticide residues on the liver. For this CRA, EFSA identified the following liver‐specific effects in accordance with the International Harmonisation of Nomenclature
European Food Safety Authority (EFSA) +8 more
wiley +1 more source
The modulation of hypoxia-inducible factor-1α/plasminogen activator inhibitor-1 axis in human gingival fibroblasts stimulated with cyclosporine A [PDF]
, 2015 Background/PurposeThe prominent side effect of the immunosuppressive drug cyclosporine A (CsA) is gingival overgrowth. Hypoxia-inducible factor (HIF)-1α regulates a wide variety of profibrogenic genes, which are closely associated with tissue fibrosis ...
Chang, Yu-Chao +5 more
core +2 more sources
Advanced Science, Volume 12, Issue 12, March 27, 2025.Quercetin intervention reshapes the overall structure of microbiota and significantly increases the abundance of beneficial gut commensal A. muciniphila. Enrichment of A. muciniphila leads to generate more ILA to facilitate cholesterol converts to CA in FTO/m6A/CYP8B1 coordinated manner, thereby reversing obesity‐related phenotypes via activating FXR ...
Jiaqi Liu +7 more
wiley +1 more source
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability [PDF]
, 2005 SummaryIndividuals with hemizygous germline fumarate hydratase (FH) mutations are predisposed to renal cancer. These tumors predominantly exhibit functional inactivation of the remaining wild-type allele, implicating FH inactivation as a tumor-promoting ...
Chung, Yuen-Li +12 more
core +1 more source
Advanced Science, Volume 12, Issue 11, March 20, 2025.Briefly, patients with ASCVD have a reduced abundance of B. ovatus in their feces. Oral administration of live B. ovatus attenuated atherosclerosis. Specifically, B. ovatus restores the expression of intestinal barrier proteins and improves bile acid metabolism, while producing the tryptophan metabolite IAA restores the M1/M2 polarisation balance by ...
Wu Liu +6 more
wiley +1 more source
Renal cortical drug and xenobiotic metabolism following urinary tract obstruction [PDF]
, 1984 Renal cortical drug and xenobiotic metabolism following urinary tract obstruction. Renal cortical metabolism of drugs and xenobiotics was assessed with microsomes prepared from normal, contralateral and 4-day postobstructive hydronephrotic kidneys ...
Davis, Bernard B. +3 more
core +1 more source
The Kynurenine Pathway and Indole Pathway in Tryptophan Metabolism Influence Tumor Progression
Cancer Medicine, Volume 14, Issue 6, March 2025.ABSTRACT Tryptophan (Trp), an essential amino acid, is solely acquired through dietary intake. It is vital for protein biosynthesis and acts as a precursor for numerous key bioactive compounds. The Kynurenine Pathway and the Indole Pathway are the main metabolic routes and are extensively involved in the occurrence and progression of diseases in the ...
Zhanhui Lu +5 more
wiley +1 more source
Blood monocyte aryl hydrocarbon hydroxylase activity in psoriasis. [PDF]
British Journal of Clinical Pharmacology, 1983 The activity of aryl hydrocarbon hydroxylase (AHH) in monocytes from 13 healthy control subjects and in 16 patients with discoid psoriasis was measured. The mean basal monocyte AHH activities of the control and psoriatic groups were 3.4 +/‐ 0.47 and 4.46 +/‐ 0.55 respectively (pmol 3‐OHBP h‐1 10(‐6) cells). This difference was not significant. The mean
S Shuster, Rawlins, G Mason
openaire +3 more sources
Role of microbiota in pain: From bench to bedside
iMetaOmics, Volume 2, Issue 1, March 2025.Pain is closely linked to microbes. The microbiota modulates pain perception through three mechanisms: microbiota‐derived metabolites, immunoregulation, and direct stimulation on neurons. Therapeutic strategies like probiotics, fecal microbiota transplantation, and dietary changes show significant potential in pain management.
Huiguang Ren +5 more
wiley +1 more source
JIMD Reports, Volume 66, Issue 2, March 2025.ABSTRACT Phenylketonuria (PKU) is an inborn error of metabolism responsible for an accumulation of phenylalanine, which leads to cognitive and developmental disorders if left untreated. Most studies of adult PKU focus on neuropsychiatric complications, but new questions have been raised about systemic manifestations of PKU in adulthood.
Yann Dos Santos +7 more
wiley +1 more source