Results 81 to 90 of about 2,826 (138)
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Aryl Hydrocarbon Hydroxylase Inducibility and Bronchogenic Carcinoma
New England Journal of Medicine, 1973Abstract Aryl hydrocarbon hydroxylase is an inducible, membrane-bound enzyme involved in the metabolism of chemical carcinogens. In cultured human lymphocytes there is genetic variation.
G, Kellermann +2 more
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Aryl Hydrocarbon Hydroxylase Induction in Human Leukocytes
Science, 1972A method for determining aryl hydrocarbon hydroxylase induction in human leukocytes is described. Leukocytes from healthy volunteers were cultured in the presence of phytohemagglutinin, a mitogen. Addition of 3-methylcholanthrene to 72-hour cultures induced a fourfold increase in aryl hydroxylase activity.
D L, Busbee, C R, Shaw, E T, Cantrell
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ACTIVITY OF ARYL HYDROCARBON HYDROXYLASE IN PSORIATIC SKIN
The Lancet, 1979The activity of aryl hydrocarbon hydroxylase (A.H.H.), a microsomal mono-oxygenase, was reduced in epidermis from both the psoriatic lesions and clinically normal lesion-free skin from psoriatic patients. Induction of epidermal A.H.H. activity by benzanthracene was also significantly less than normal in both psoriatic lesions and in clinically normal ...
P H, Chapman, M D, Rawlins, S, Shuster
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ARYL-HYDROCARBON-HYDROXYLASE INDUCIBILITY IN PATIENTS WITH CANCER
The Lancet, 1978Aryl-hydrocarbon-hydroxylase (A.H.H.) inducibility has been studied in the peripheral-blood lymphocytes of patients with squamous-cell lung cancer, of patients with cancer at other sites, and of controls matched for age, sex, social class, and smoking habits. The proportion of high inducers was significantly greater among patients with lung cancer (but
A E, Emery +4 more
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Aryl Hydrocarbon Hydroxylase Inducibility in Laryngeal Carcinoma
Archives of Otolaryngology - Head and Neck Surgery, 1978The chief carcinogens of tobacco smoke--the polycyclic aromatic hydrocarbons--must be activated in the cells to exert their carcinogenic effect. This activation is carried out by the enzyme system aryl hydrocarbon hydroxylase (AHH). Mitogen-stimulated, human lymphocyte studies of AHH activity indicate wide individual variation, which is under strict ...
J H, Brandenburg, G, Kellermann
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Aryl hydrocarbon hydroxylase and 16?-hydroxylase in cultured human lymphocytes
Biochemical Genetics, 1976Aryl hydrocarbon hydroxylase and 16alpha-hydroxylase were examined in intact, cultured human lymphocytes. The two microsomal mixed-function oxygenases had different pH optima and showed competitive inhibition for enzyme induction and activity. Population distributions were lognormal for both enzymes, giving apparent evidence for polygenic control ...
M L, Coomes +5 more
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Aryl Hydrocarbon Hydroxylase: Induction
1977Knowledge about the enzyme system responsible for the metabolism of aryl hydrocarbons dates back to the early studies of Conney et al. (1), who showed the enzyme(s) responsible for the oxidation of benzpyrene to be located in the microsomal fraction of the liver. In that study it was shown that the enzyme system required both NADPH and molecular oxygen
John B. Schenkman +2 more
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Hydrocarbon-based oils as inducers of cutaneous aryl hydrocarbon hydroxylase
Toxicology Letters, 1982Petroleum-based oils applied to the skin of rats induced cutaneous aryl hydrocarbon hydroxylase activity. A heavy oil like Kuwait Crude induced benzo(a)pyrene (BaP) hydroxylase and diphenyloxazole (PPO) hydroxylase activities to levels obtained with Aroclor 1254, while a light oil like Fuel Oil No. 2 was less effective.
A D, Rahimtula, J F, Payne, I, Martins
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In Vitro Inhibition of Aryl Hydrocarbon Hydroxylase by Heavy Metals
Oncology, 2009Inhibition of mouse hepatic aryl hydrocarbon hydroxylases (AHH), microsomal mixed-function oxidases was obtained with five bivalent metal chlorides. Concentrations ranged from 10––6 to 10––1 m. The enzyme system was induced by an intraperitoneal injection of a trioctanoin solution of 3-methylcholanthrene into C57B1/6J mice 24 hours before the hepatic ...
S, Tsang, A, Furst
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Flavone Modulators of Rat Hepatic Aryl Hydrocarbon Hydroxylase
Pharmacology, 2008The cytochrome P-450-dependent aryl hydrocarbon hydroxylase (AHH) metabolizes a wide variety of endogenous and exogenous compounds to nontoxic metabolites and/or toxic products. We have utilized a series of 18 flavone modulators of AHH to distinguish and probe for different cytochrome P-450 isozymes in liver microsomes from control and 3 ...
F K, Friedman +3 more
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