Results 141 to 150 of about 33,261 (251)

The metabolic‐immune hub: Dual roles of indoleamine 2,3‐dioxygenase in the acute kidney injury‐to‐chronic kidney disease transition and therapeutic perspectives

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
1. Indoleamine 2,3‐dioxygenase (IDO) acts as a time‐dependent metabolic–immune switch in the acute kidney injury‐to‐chronic kidney disease transition, protective early but pathogenic when sustained. 2. Early protection (regulatory T cell expansion, M2 polarisation and ferroptosis suppression) gives way to general control nonderepressible 2‐driven ...
Ziyi Qiu, Binbin Pan
wiley   +1 more source

Integrin α5β1 in pancreatic ductal adenocarcinoma: Tumour‒stroma crosstalk, hypoxia and therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ITGA5/integrin α5β1 promotes PDAC progression by integrating fibronectin‐dependent adhesion, hypoxia‐associated ECM remodelling, pancreatic stellate cell/cancer‐associated fibroblast activation, desmoplasia and tumour‒stroma crosstalk. These processes contribute to impaired drug delivery and therapeutic resistance.
Chenzhe Ma, Yingying Wang, Yumin Li
wiley   +1 more source

Braking the system: the aryl hydrocarbon receptor controls monocytes in homeostasis. [PDF]

J Clin Invest
Kenison JE, Quintana FJ.
europepmc   +1 more source

SLC7A5 promotes colorectal cancer liver metastasis by reprogramming tryptophan metabolism through the Kyn/XANA‒AhR axis and reshaping the immune microenvironment

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
SLC7A5‒Kyn/XANA signalling activates AhR to drive EMT and metastatsis. SLC7A5 knockdown enhances macrophage antigen presentation and reverses CD8+ T‐cell exhaustion. SLC7A5 knockdown induces antigen‐driven and IgG‐secreting B‐cell clonal expansion. Combination of SLC7A5 inhibition and anti‐PD‐1 therapy offers clinical targeting.
Yaohao Luo, Lei Li, Shanbao Li, Xinshuai Wang, Zeping He, Fangbin Song, Jun Qin, Jinyan Zhang, Junming Xu   +8 more
wiley   +1 more source

Inhibition of Aryl hydrocarbon receptor Interleukin-22 signaling and worsening of intestinal inflammation by <i>Sutterella</i> species. [PDF]

Gut Microbes
Dupraz L, Orianne G, Da Costa G, Gauthier R, Blondeau A, Boinet M, Farfar A, Creusot L, Magniez A, Dubois L, Guarino-Vignon P, Chollet L, Rolhion N, Danne C, Dvořák Z, Seksik P, Berteau O, Sokol H, Michel ML.   +18 more
europepmc   +1 more source

Indole‐3‐Propionic Acid Alleviates Metabolic Dysfunction‐Associated Fatty Liver Disease via AHR/AMPK Signaling Activation

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
IPA promotes AHR nuclear translocation and AMPK phosphorylation. Phosphorylated AMPK may in turn facilitate AHR translocation, suggesting a potential reciprocal interplay that contributes to alleviating hepatic lipid deposition in MAFLD. ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD) is a health problem worthy of attention ...
Yanting Huang, Meimei Yu, Jiaxin Lu, Chujun Lin, Shuhuan Li, Yalin Chen, Xin Chen, Hongliang Xue, Jing Chen, Lijie Su   +9 more
wiley   +1 more source

Activation of aryl hydrocarbon receptor alleviates cholestatic liver injury by inhibiting inflammation. [PDF]

Cell Commun Signal
Han Q, Wang L, Yan X, Zhang N, Zhang W, Li H, Chen W, You H, Yang A.   +8 more
europepmc   +1 more source

The Role of Immunoresolvents in Atherosclerosis: A Mini‐Review on Their Biology and Therapeutic Opportunities

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Atherosclerosis is a lipid‐induced chronic inflammatory cardiovascular disorder denoted by the infiltration of immune cells and the agglomeration of lipids in the intima, the innermost layer, of the arteries of large and medium sizes.
Ramin Lotfi, Alireza Nasirifar, Hoda Rahmani, Sara Falahi, Meysam Kashiri   +4 more
wiley   +1 more source

The aryl hydrocarbon receptor: structure, signaling, physiology and pathology. [PDF]

Signal Transduct Target Ther
Coumoul X, Barouki R, Esser C, Haarmann-Stemmann T, Lawrence BP, Lehmann J, Moura-Alves P, Murray IA, Opitz CA, Perdew GH, Bourguet W.   +10 more
europepmc   +1 more source

Industrial Hydrocarbons Exposure Deteriorates Sperm Integrity and Reproductive Function

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ABSTRACT Occupational exposure to polycyclic aromatic hydrocarbons (PAHs) or metal fumes in the workplace may be detrimental to male fertility. The present study compared sperm concentration, total motility, strict morphology and oxidative stress and SDF levels between 81 men, controls (n = 17) and workers from plastic industry workers (n = 18), steel ...
Madhan Kumar Pichandi, Babujanarthanam Ranganathanan, Doraiah Abilash   +2 more
wiley   +1 more source