Results 141 to 150 of about 60,384 (208)

Modulating IDO1 and TDO Inhibition Through Structural Modification of Diaryl Hydroxylamines

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Diaryl hydroxylamines have emerged as promising scaffolds for targeting the tryptophan‐catabolizing enzymes indoleamine 2,3‐dioxygenase 1 (IDO1) and tryptophan 2,3‐dioxygenase (TDO), key drivers of tumor immune escape. Building on the reported dual IDO1/TDO inhibitory activity of O‐((3,5‐difluorophenyl)(phenyl)methyl)hydroxylamine, a series of diaryl ...
Angeliki S. Foscolos, Alexandros Pappas, Christos N. Petroulias, Anna Kapella, Georgia M. Prifti, Grigoris Zoidis, Minas Papadopoulos, Anastasia Mpakali, Aristeidis Chiotellis   +8 more
wiley   +1 more source

Whole-Body Knockout of the AhR (Aryl Hydrocarbon Receptor) Ameliorates Atherosclerosis Due to Altered Lipid Metabolism-Brief Report. [PDF]

Arterioscler Thromb Vasc Biol
Huchzermeier R, de Jong RJ, Rakateli L, Bonnin-Marquez A, Maas SL, Maassen-Pöttgens C, Abschlag K, Jin H, Geiselhöringer AL, Triantafyllidou V, Santovito D, Jankowski J, Biessen EAL, Ohnmacht C, van der Vorst EPC.   +14 more
europepmc   +1 more source

Back to the Electrofuture: Named Reactions Powered by Electroorganic Syntheses

ChemSusChem, Volume 19, Issue 7, 14 April 2026.
Bridging classical named reactions with modern electroorganic chemistry, this review presents how electrochemical strategies can revive and reinterpret historically significant transformations, highlighting their emerging potential as sustainable alternatives in contemporary organic synthesis.
Debajit Maiti, Yoonji Heo, Geon Kang, Min Kim, Isaac Choi   +4 more
wiley   +1 more source

Aryl hydrocarbon receptor deficiency enhances astrocyte sensitivity to LPS-induced inflammation. [PDF]

Front Cell Neurosci
Ojo E, Tischkau SA.
europepmc   +1 more source

Functional genomic analysis of non-canonical DNA regulatory elements of the aryl hydrocarbon receptor. [PDF]

Toxicol Sci
Shahriar S, Patel TD, Nakka M, Grimm SL, Coarfa C, Gorelick DA.   +5 more
europepmc   +1 more source

Attenuation of microglial aryl hydrocarbon receptor alters astrocyte activation and chronic pain sensitization in aging. [PDF]

Open Life Sci
Sun JX, Huang Y, Zheng JJ, Xie WQ.
europepmc   +1 more source

Aryl hydrocarbon receptor suppresses inflammation [PDF]

Nature Reviews Drug Discovery, 2018
openaire   +1 more source

The aryl hydrocarbon receptor (AHR) drives human leukocyte antigen (HLA)-II expression in human melanoma. [PDF]

J Exp Clin Cancer Res
Jin Y, Zheng W, Zhang R, Hou S, Luo C, Ren P, Pan D, Luo C, Zeng Z.   +8 more
europepmc   +1 more source

Embryonic and Postnatal Expression of Aryl Hydrocarbon Receptor mRNA in Mouse Brain [PDF]

, 2017
Chiharu Tohyama, Eiki Kimura
core   +1 more source

Tryptophan Indole Metabolites Reduce Anastomotic Leakage Through Aryl Hydrocarbon Receptor-Driven Interleukin-22 Production. [PDF]

Cell Mol Gastroenterol Hepatol
Bantavi V, Gloeck L, Leven P, Zafeiropoulou K, Welting O, Sengül H, Efferz P, Schneiker B, McCulloch TR, Wilhelm C, Blaess S, Fuss A, REVEAL study group, Derikx JPM, Sovran B, de Jonge WJ, Wehner S.   +16 more
europepmc   +1 more source