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Using fish models to understand the role of aryl hydrocarbon receptor (AHR)-interacting protein (AIP) in controlling sensitivity and resistance to dioxin-like compounds in vivo. [PDF]

Toxicol Sci
Karchner SI, Aluru N, Franks DG, Mandl CA, Goldstone JV, Burke T, Champlin D, La Du JK, Perone DM, Stinson S, Truong L, Clark BW, Nacci D, Tanguay RL, Hahn ME.   +14 more
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Etoricoxib enhances aryl hydrocarbon receptor activity

Toxicology, 2023
Etoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that possesses properties that include reducing inflammation and relieving pain and fever. Etoricoxib is an oral medication that selectively inhibits cyclooxygenase-2 with high efficacy. Controversies about its cardiovascular side effects have long existed.
Hsiao-Ho, Fang, Jiun, Hsu, Jyan-Gwo Joseph, Su   +2 more
openaire   +2 more sources

Aryl hydrocarbon receptor and colitis

Seminars in Immunopathology, 2013
The aryl hydrocarbon receptor (AhR), a transcription factor activated by a large variety of natural and synthetic ligands, has recently become the object of great interest among researchers since it represents an important link between environment and immune-mediated pathologies.
MONTELEONE, IVAN, PALLONE, FRANCESCO, MONTELEONE, GIOVANNI   +2 more
openaire   +3 more sources

The Aryl Hydrocarbon Receptor Complex

Annual Review of Pharmacology and Toxicology, 1995
The heteromeric unliganded aryl hydrocarbon receptor complex (AHRC) contains the aryl hydrocarbon receptor monomer (AHR). Binding of polycyclic or halogenated aromatic hydrocarbon (PAH and HAH) ligand causes release of AHR, which then associates with the AHR nuclear translocator protein (ARNT) to generate the heterodimeric "transformed" AHRC.
openaire   +2 more sources

The aryl hydrocarbon receptor in immunity

Trends in Immunology, 2009
Low-molecular-weight chemicals or xenobiotics might contribute to the increasing prevalence of allergies and autoimmunity. Certain chemicals can alter immune responses via their action on the cytosolic transcription factor aryl hydrocarbon receptor (AhR).
Charlotte, Esser, Agneta, Rannug, Brigitta, Stockinger   +2 more
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Aryl hydrocarbon receptor and unexplained miscarriage

Journal of Obstetrics and Gynaecology Research, 2017
AbstractAimThe aim of this study was to carry out a preliminary investigation of the expression of aryl hydrocarbon receptor (AhR) in decidua and villus and the relationship between AhR and unexplained miscarriage.MethodsThe expression of AhR mRNA and protein from decidua and villus were measured using real‐time reverse transcription–polymerase chain ...
Hongjie, Fan, Xiaoling, Su, Binlie, Yang, Aimin, Zhao   +3 more
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The aryl hydrocarbon receptor and light

Biological Chemistry, 2006
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been intensively studied with respect to the toxicity of xenobiotics. However, its function in response to light has never been summarized. Here, we provide an overview of AhR activation by light with a focus on the role of tryptophan in light-induced AhR activation.
Agneta, Rannug, Ellen, Fritsche
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Aryl Hydrocarbon Receptor-Mediated Signal Transduction

Critical Reviews in Toxicology, 1997
The aryl hydrocarbon (or dioxin) receptor (AhR) is a ligand-activated basic helix-loop-helix (bHLH) protein that heterodimerizes with the bHLH protein ARNT (aryl hydrocarbon nuclear translocator) forming a complex that binds to xenobiotic regulatory elements in target gene enhancers.
J C, Rowlands, J A, Gustafsson
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Identification of functional aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator in murine splenocytes

Biochemical Pharmacology, 1996
The objective of the present studies was to determine whether the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) protein are present and functional in B6C3F1 (C57BL/6 x C3H) mouse splenocytes. Northern analysis of poly(A) RNA isolated from splenocytes revealed transcripts of approximately 6.6 kb which hybridized to the AhR ...
C E, Williams, R B, Crawford, M P, Holsapple, N E, Kaminski   +3 more
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