Results 181 to 190 of about 33,261 (251)

Targeting the Aryl Hydrocarbon Receptor: The Potential of Indole Compounds in the Treatment of Cystic Fibrosis. [PDF]

Int J Mol Sci
Hou S, Yue Q, Hou X, Wu Q.
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Attenuation of microglial aryl hydrocarbon receptor alters astrocyte activation and chronic pain sensitization in aging. [PDF]

Open Life Sci
Sun JX, Huang Y, Zheng JJ, Xie WQ.
europepmc   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, Volume 293, Issue 15, Page 4533-4553, August 2026.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity. [PDF]

Nat Commun
Ghosh S, Vanwinkle ZM, Bodduluri SR, Juin SK, Kadari M, Singh A, Dryden GW, Lawrenz MB, Kanneganti TD, Rai SN, Good M, Kumar P, Haribabu B, Jala VR.   +13 more
europepmc   +1 more source

Amino acid homeostasis in the kidney: Physiological roles and pathological dysregulation

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Amino acids are fundamental to life as protein building blocks and key regulators of metabolism and signaling. The kidney plays a critical, yet underappreciated, role in amino acid homeostasis through three interconnected pillars: selective glomerular filtration, efficient tubular reabsorption, and metabolic processing, which includes de novo ...
Shuo Liu, Caifeng Shi, Yang Zhou, Chunsun Dai   +3 more
wiley   +1 more source

Aryl Hydrocarbon Receptor-Mediated Disruption of Intestinal Epithelial Barrier Integrity by Dioxin Isomers. [PDF]

Toxics
Kakutani H, Nakao T.
europepmc   +1 more source

The Role of Gut Microbiota in Liver Regeneration After Partial Hepatectomy: New Evidence From Animal and Human Studies

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Partial hepatectomy (PH) reshapes gut microbiota composition, resulting in the release of microbial metabolites and components, including short chain fatty acids (SCFAs)/β‐hydroxybutyric acid (BHB), bacterial DNA and extracellular vesicles (EVs), bile acids (deoxycholic acid, DCA), and aminobenzoate degradation products.
Roberto Loi, Gabriella Simbula, Andrea Caddeo, Monica Pibiri   +3 more
wiley   +1 more source

Tryptophan Indole Metabolites Reduce Anastomotic Leakage Through Aryl Hydrocarbon Receptor-Driven Interleukin-22 Production. [PDF]

Cell Mol Gastroenterol Hepatol
Bantavi V, Gloeck L, Leven P, Zafeiropoulou K, Welting O, Sengül H, Efferz P, Schneiker B, McCulloch TR, Wilhelm C, Blaess S, Fuss A, REVEAL study group, Derikx JPM, Sovran B, de Jonge WJ, Wehner S.   +16 more
europepmc   +1 more source

Acyclic Hydrocarbon α,ω‐Dienes: From Biomass and Plastic Upcycling to Carbocycles, Precision Polymers, and Cross‐Linked Elastomers

ChemSusChem, Volume 19, Issue 14, 29 July 2026.
Hydrocarbon α,ω‐dienes are mainly produced from steam‐cracking derivatives, but high costs, complexity, and environmental impact limit their use. This review highlights sustainable paths from biomass and plastic upcycling, and surveys catalytic transformations into carbocycles and specialty polymers, emphasizing their role as modular building blocks ...
Rosa Villaccio, Giuseppe Leone
wiley   +1 more source