Results 191 to 200 of about 33,160 (231)
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The Aryl Hydrocarbon Receptor Complex
Annual Review of Pharmacology and Toxicology, 1995The heteromeric unliganded aryl hydrocarbon receptor complex (AHRC) contains the aryl hydrocarbon receptor monomer (AHR). Binding of polycyclic or halogenated aromatic hydrocarbon (PAH and HAH) ligand causes release of AHR, which then associates with the AHR nuclear translocator protein (ARNT) to generate the heterodimeric "transformed" AHRC.
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The Aryl Hydrocarbon Receptor: Multitasking in the Immune System
Annual Review of Immunology, 2014The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has more recently attracted the attention of immunologists.
Brigitta Stockinger +2 more
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Cyprodinil as an activator of aryl hydrocarbon receptor
Toxicology, 2013Cyprodinil is a pyrimidinamine fungicide, used worldwide by agriculture. It is used to protect fruit plants and vegetables from a wide range of pathogens. Benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are toxic environmental pollutants and are prototypes of aryl hydrocarbon receptor (AHR) ligands.
Chien-Chung, Fang +6 more
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Functions of the aryl hydrocarbon receptor in the skin
Seminars in Immunopathology, 2013Among other functions, the skin serves as the barrier against the environment and provides vital protection from physical or chemical harm and from infection. Skin cells express the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor and sensor of environmental chemicals; at the same time, AHR ligands are abundant in skin from ...
Charlotte, Esser +4 more
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Role of aryl hydrocarbon receptor in cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2013Aryl hydrocarbon receptor (AHR), a cytosolic ligand-activated transcription factor, belongs to the member of bHLH/PAS family of heterodimeric transcriptional regulators and is widely expressed in a variety of animal species and humans. Recent animal and human data suggested that AHR is involved in various signaling pathways critical to cell normal ...
Shaolong, Feng +2 more
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Aryl hydrocarbon receptor and unexplained miscarriage
Journal of Obstetrics and Gynaecology Research, 2017AbstractAimThe aim of this study was to carry out a preliminary investigation of the expression of aryl hydrocarbon receptor (AhR) in decidua and villus and the relationship between AhR and unexplained miscarriage.MethodsThe expression of AhR mRNA and protein from decidua and villus were measured using real‐time reverse transcription–polymerase chain ...
Hongjie, Fan +3 more
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Trends in Endocrinology & Metabolism, 1994
The aryl hydrocarbon (AH, or dioxin) receptor mediates carcinogenesis by a wide variety of compounds. It acts as a ligand-dependent transcription factor. Many investigators expected that the AH receptor would prove to be a member of the steroid/thyroid/retinoic acid receptor superfamily of proteins.
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The aryl hydrocarbon (AH, or dioxin) receptor mediates carcinogenesis by a wide variety of compounds. It acts as a ligand-dependent transcription factor. Many investigators expected that the AH receptor would prove to be a member of the steroid/thyroid/retinoic acid receptor superfamily of proteins.
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A snapshot of the aryl hydrocarbon receptor complex
Structure, 2023In this issue of Structure, Wen et al. present the cryo-EM structure of the aryl hydrocarbon receptor (AhR) and show how it is recruited and stabilized by the HSP90 molecular chaperone and its co-chaperones XAP2 and p23.
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The aryl hydrocarbon receptor: A comparative perspective
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1998The aryl hydrocarbon receptor (Ah receptor or AHR) is a ligand-activated transcription factor involved in the regulation of several genes, including those for xenobiotic-metabolizing enzymes such as cytochrome P450 1A and 1B forms. Ligands for the AHR include a variety of aromatic hydrocarbons, including the chlorinated dioxins and related halogenated ...
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Dexlansoprazole is an aryl hydrocarbon receptor agonist
Food and Chemical ToxicologyDexlansoprazole, a proton pump inhibitor, is commonly used to treat gastro-esophageal reflux disease and erosive esophagitis. The activated aryl hydrocarbon receptor (AhR) functions as a transcription factor by binding to the aryl hydrocarbon response element (AHRE) of its target genes, with cytochrome P450 (CYP) 1A1 being the most well-known target ...
Kuo-Liang Wei +6 more
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