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The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases [PDF]
International Journal of Molecular Sciences, 2018 The aryl hydrocarbon receptor (AHR) is a nuclear receptor that modulates the response to environmental stimuli. It was recognized historically for its role in toxicology but, in recent decades, it has been increasingly recognized as an important ...
Drew R Neavin +2 more
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Relevance of the Aryl Hydrocarbon Receptor (AhR) for Clinical Toxicology
Clinical Toxicology, 2009The aryl hydrocarbon receptor (AhR) is a cellular signaling molecule infamous for mediating the toxicity of dioxins and related compounds.The aim of this review is to provide a background of AhR and to examine critically its role in chemical toxicity, in physiological systems, and its interaction with drugs and other compounds.The AhR is essential for ...
Tracey D Bradshaw, David Bell
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Predictive modeling of aryl hydrocarbon receptor (AhR) agonism
Chemosphere, 2020The aryl hydrocarbon receptor (AhR) plays a key role in the regulation of gene expression in metabolic machinery and detoxification systems. In the recent years, this receptor has attracted interest as a therapeutic target for immunological, oncogenic and inflammatory conditions. In the present report, in silico and in vitro approaches were combined to
Goya-Jorge, Elizabeth +4 more
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Ligands and agonists of the aryl hydrocarbon receptor AhR: Facts and myths
Biochemical Pharmacology, 2023The aryl hydrocarbon receptor (AhR) belongs to the essential helix-loop-helix transcription factors family. This receptor has a central role in determining host physiology and a variety of pathophysiologies ranging from inflammation and metabolism to cancer. AhR is a ligand-driven receptor with intricate pharmacology of activation depending on the type
Sládeková, Lucia +2 more
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Regulation of Subcellular Localization of the Aryl Hydrocarbon Receptor (AhR)
Archives of Biochemistry and Biophysics, 2001The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity of dioxin and other xenobiotics. In the absence of exogenous ligand, AhR is cytosolic. We investigated how AhR is retained in the cytosol and how dioxin induces AhR to move to the nucleus.
C A, Richter, D E, Tillitt, M, Hannink
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The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis
Pigment Cell & Melanoma Research, 2010SummarySkin cancer, chloracne and hyperpigmentation have been associated with the exposure to environmental contaminants such as polychlorinated biphenyls, dioxins or polycyclic aromatic hydrocarbons. These compounds are xenobiotic high‐affinity ligands for the aryl hydrocarbon receptor (AHR), a ligand‐activated transcription factor with important ...
Sandra, Luecke +5 more
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Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs)
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2002Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous, environmental contaminants that pose a potential risk to fish populations. Both field and laboratory studies suggest that exposure of the early life stages of fish to PAH can mimic the embryotoxic effects of the planar halogenated hydrocarbons (PHHs), the most potent of which is 2,3,7,8 ...
Sonya M, Billiard +5 more
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Archives of Biochemistry and Biophysics, 2002
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) activates the aryl hydrocarbon receptor (AhR) to mediate transcriptional activity of dioxin-responsive genes. The transactivation domain (TAD) of human AhR (hAhR) has potentially distinct acidic, glutamine-rich, and proline/serine/threonine-rich subdomains.
Rashmeet K, Reen +2 more
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) activates the aryl hydrocarbon receptor (AhR) to mediate transcriptional activity of dioxin-responsive genes. The transactivation domain (TAD) of human AhR (hAhR) has potentially distinct acidic, glutamine-rich, and proline/serine/threonine-rich subdomains.
Rashmeet K, Reen +2 more
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Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1
Breast Cancer Research and Treatment, 2000Exposure to ubiquitous environmental chemicals, such as polycyclic aromatic hydrocarbons (PAH), may contribute to human breast cancer. In animals, PAH induce tumors in part by activating the aryl hydrocarbon receptor (AhR)/transcription factor. Historically, investigations into AhR-regulated carcinogenesis have focused on AhR-dependent transcriptional ...
Anthony F. Trombino +9 more
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Interactions between aryl hydrocarbon receptor (AhR) and hypoxia signaling pathways
Environmental Toxicology and Pharmacology, 2001Most if not all of the toxic responses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are mediated through the AhR, which requires ARNT to regulate gene expression. ARNT is also required by HIF-1alpha to enhance the expression of various genes in response to hypoxia.
M, Nie, A L., Blankenship, J P., Giesy
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