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<em>In Silico</em> Screening and Analysis of Potential Inhibitors of Arylamine N-Acetyltransferases (NATs) from the Traditional Chinese Medicine: A Study Using Free Available Tools

, 2017
Francisco Azevedo, Joveline Richardt, Mayrla Oliveira, Inês M. Araújo, Ricardo Oliveira, Luis A. Baptista, Hermes Luís Neubauer de Amorim   +6 more
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Improved genotyping of N-acetyltransferase 2 [PDF]

Blaszkewicz, Meinolf
core   +1 more source

Functional consequences of urinary bladder cancer risk variants [PDF]

, 2013
Selinski, Silvia
core  

Characterization of acetylator genotype-dependent and -independent hamster hepatic n-acetyltransferases and their role in the metabolism of arylamine and n-hydroxyarylamine carcinogens

, 1989
A Trinidad
openalex   +1 more source

Arylamine N-acetyltransferase in adult mouse brain

, 2016
Mo, M, Wakefield, L, French, S, Kawamura, A, Sim, E   +4 more
openaire   +1 more source

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Contrasting Effects of Temperature on Human Arylamine N-Acetyltransferase and Acetyl Coenzyme A Hydrolase Activities.

Biochemistry, 2023
There are two human arylamine N-acetyltransferases (NAT1 and NAT2) that have evolved separately and differ in their substrate specificity and tissue localization.
C. Choudhury, Courtney E. McAleese, N. Butcher, R. Minchin   +3 more
semanticscholar   +1 more source

ArylamineN-acetyltransferases

Expert Opinion on Drug Metabolism & Toxicology, 2007
Arylamine N-acetyltransferases (NATs), known as drug- and carcinogen-metabolising enzymes, have had historic roles in cellular metabolism, carcinogenesis and pharmacogenetics, including epidemiological studies of disease susceptibility. NAT research in the past 5 years builds on that history and additionally paves the way for establishing the following
Sim, Edith, Westwood, Isaac, Fullam, Elizabeth   +2 more
openaire   +3 more sources

Arylamine N-acetyltransferases

Toxicology, 2008
Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines, arylhydroxylamines and arylhydrazines with the acetyl group being transferred from acetylCoenzyme A. As a result of many recent advances in NAT research there have been many recent reviews and the present paper gives a flavour of the excitement in the field. The NATs, which
Sim, Edith, Lack, Nathan, Wang, Chan-Ju, Long, Hilary, Westwood, Isaac, Fullam, Elizabeth, Kawamura, Akane   +6 more
openaire   +2 more sources

Arylamine N-acetyltransferase I

The International Journal of Biochemistry & Cell Biology, 2007
Arylamine N-acetyltransferase I (NAT1) is a phase II enzyme that acetylates a wide range of arylamine and hydrazine substrates. The NAT1 gene is located on chromosome 8 and shares homology to NAT genes found in most mammalian species. Gene expression occurs from at least two promoters and a number of tissue-specific transcripts have been identified ...
Minchin, RF, Hanna, PE, Dupret, JM, Wagner, CR, Rodrigues-Lima, F, Butcher, NJ   +5 more
openaire   +3 more sources

Regulation of Arylamine N-Acetyltransferases

Current Drug Metabolism, 2008
Acetylation catalysed by the arylamine N-acetyltransferases (NATs; 2.3.1.5) is a major biotransformation pathway for arylamine and hydrazine drugs, as well as many carcinogens that we are exposed to on a daily basis. These compounds can either be detoxified by NATs or bioactivated to metabolites that have the potential to cause toxicity such as cancer.
Butcher, Neville J., Tiang, Jacky, Minchin, Rodney F.   +2 more
openaire   +3 more sources