Results 101 to 110 of about 15,724 (296)
Lead toxicity and genetics in Flint, MI [PDF]
, 2018 It has been well established that lead poisoning, as defined by the CDC as blood lead levels (BLLs) at or above 5 μg/dl, can lead to long-term neurotoxic effects in children and requires immediate treatment.
Housman, David E +2 more
core +1 more source
Prostate Cancer and Prostatic Diseases, 2013 Background:The enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) degrades chondroitin-4-sulfate (C4S) and is reduced in malignant colonic and mammary tissues but has not previously been evaluated in prostate cancer.Methods:ARSB ...
Leo Feferman +6 more
openalex +2 more sources
CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.We identified and validated 25 causal protein targets linked to Parkinson's disease (PD) onset and progression using proteomic and genetic analyses. Using plasma and brain large‐scale pQTL datasets, we conducted proteome‐wide association studies (PWAS) and Mendelian randomization (MR) to assess causality.
Chenhao Gao +13 more
wiley +1 more source
Archiv der Pharmazie, Volume 358, Issue 1, January 2025.The pre‐ADMET properties of 5‐(3′,4′‐dihydroxyphenyl)‐γ‐valerolactone (VL) are evaluated for the first time. VL is rapidly metabolized and absorbed as its sulfate phase II conjugate (valerolactone sulfate). In the human S9 liver fraction, VL is metabolized into glucuronic phase II conjugates.
Larissa Della Vedova +9 more
wiley +1 more source
Arylsulfatase K, a Novel Lysosomal Sulfatase [PDF]
Journal of Biological Chemistry, 2013 The human sulfatase family has 17 members, 13 of which have been characterized biochemically. These enzymes specifically hydrolyze sulfate esters in glycosaminoglycans, sulfolipids, or steroid sulfates, thereby playing key roles in cellular degradation, cell signaling, and hormone regulation.
Wiegmann, Elena +5 more
openaire +2 more sources
Ocular Manifestation in a Rare Case of Mucopolysaccharidosis VI
Journal of Mazandaran University of Medical Sciences, 2021 Mucopolysaccharidosis VI is an inherited autosomal recessive disease that causes glycosaminoglycan deposition in different tissues due to arylsulfatase deficiency that can cause various systemic and ocular manifestations.
Leila Rezaei, Naser Aghaei
doaj
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 11, Issue 1, January-March 2025.Abstract INTRODUCTION Biomarkers (BMs) are valuable tools to facilitate early diagnosis of (subtypes of) diseases, improve patient selection and stratification, and detect therapeutic effects or safety concerns. This study explores the extent to which BMs are utilized in the development of treatments for neurodegenerative diseases (NDDs), as well as ...
Audrey M. M. Hermans +8 more
wiley +1 more source
Riding the sulfur cycle - metabolism of sulfonates and sulfate esters in Gram-negative bacteria [PDF]
, 2017 Sulfonates and sulfate esters are widespread in nature, and make up over 95% of the sulfur content of most aerobic soils. Many microorganisms can use sulfonates and sulfate esters as a source of sulfur for growth, even when they are unable to metabolize ...
Kertesz, Michael A.
core
Expanding the genetic landscape of Usher syndrome type IV caused by pathogenic ARSG variants
Clinical Genetics, Volume 107, Issue 1, Page 44-55, January 2025.Mutations in ARSG are a very rare cause of Usher disease, assigned as “Usher type IV.” We identified 13 new subjects with mutations in ARSG, provide a clinical description of the subjects, and characterized the newly identified variants. Abstract Usher syndrome (USH) is the most common cause of deafblindness.
Miriam Bauwens +24 more
wiley +1 more source
Journal of Microbiology and Biotechnology, 2015 A novel sulfatase gene, ary423 (1,536 bp ORF), encoding a protein of 511 amino acids with a calculated molecular mass of 56 kDa, was identified from Flammeovirga pacifica, which was isolated from deep-sea sediments of west Pacific Ocean.
Chao Gao, Min Jin, Zhiwei Yi, R. Zeng
semanticscholar +1 more source