Results 1 to 10 of about 1,001 (167)

Identification of a Sulfatase that Detoxifies Glucosinolates in the Phloem-Feeding Insect Bemisia tabaci and Prefers Indolic Glucosinolates. [PDF]

Front Plant Sci, 2021
Cruciferous plants in the order Brassicales defend themselves from herbivory using glucosinolates: sulfur-containing pro-toxic metabolites that are activated by hydrolysis to form compounds, such as isothiocyanates, which are toxic to insects and other ...
Manivannan A, Israni B, Luck K, Götz M, Seibel E, Easson MLAE, Kirsch R, Reichelt M, Stein B, Winter S, Gershenzon J, Vassão DG.   +11 more
europepmc   +3 more sources

Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid Eulalia sp. onto Ovarian Cancer Cells. [PDF]

Mar Drugs, 2021
The Portuguese Foundation for Science and Technology (FCT) funded project WormALL (PTDC/BTA-BTA/28650/2017) plus the grants SFRH/BD/109462/2015 to A.P.R., and CEECIND/02699/2017 to A.R.G.
Rodrigo AP, Mendes VM, Manadas B, Grosso AR, Alves de Matos AP, Baptista PV, Costa PM, Fernandes AR.   +7 more
europepmc   +3 more sources

Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily [PDF]

Journal of the American Chemical Society, 2019
Highly proficient, promiscuous enzymes can be springboards for functional evolution, able to avoid loss of function during adaptation by their capacity to promote multiple reactions.
Bayer, C, Dutruel, C, Fischer, G, Hollfelder, F, Hyvonen, M, Jonas, S, Mohamed, M, Valkov, E, van Loo, Bert, Vorobieva, A   +9 more
core   +3 more sources

Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding. [PDF]

Acta Crystallogr D Struct Biol, 2022
This work was supported by the Spanish Ministry of Science and Innovation/FEDER grants PID2020-116261GB-I00 (JAG) and RTI2018-097991-B-I00 (JLN), Secretaria General de Universidades, Investigacion y Tecnologia, Junta de Andalucia (PY20-00149 and UAL18 ...
Gavira JA, Cámara-Artigas A, Neira JL, Torres de Pinedo JM, Sánchez P, Ortega E, Martinez-Rodríguez S.   +6 more
europepmc   +3 more sources

Pre-ADMET studies of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, the bioactive intestinal metabolite of proanthocyanidins. [PDF]

Arch Pharm (Weinheim)
The pre‐ADMET properties of 5‐(3′,4′‐dihydroxyphenyl)‐γ‐valerolactone (VL) are evaluated for the first time. VL is rapidly metabolized and absorbed as its sulfate phase II conjugate (valerolactone sulfate). In the human S9 liver fraction, VL is metabolized into glucuronic phase II conjugates.
Della Vedova L, Husain I, Wang YH, Kothapalli HB, Gado F, Baron G, Manzi S, Morazzoni P, Aldini G, Khan IA.   +9 more
europepmc   +2 more sources

Expanding the genetic landscape of Usher syndrome type IV caused by pathogenic ARSG variants. [PDF]

Clin Genet
Mutations in ARSG are a very rare cause of Usher disease, assigned as “Usher type IV.” We identified 13 new subjects with mutations in ARSG, provide a clinical description of the subjects, and characterized the newly identified variants. Abstract Usher syndrome (USH) is the most common cause of deafblindness.
Bauwens M, De Man V, Audo I, Balikova I, Zein WM, Smirnov V, Held S, Vermeer S, Loos E, Jacob J, Casteels I, Désir J, Depasse F, Van de Sompele S, Van Heetvelde M, De Bruyne M, Andrieu C, Condroyer C, Antonio A, Hufnagel R, Carvalho AL, Marques JP, Zeitz C, De Baere E, Damme M.   +24 more
europepmc   +2 more sources

Assimilation of alternative sulfur sources in fungi. [PDF]

World J Microbiol Biotechnol, 2018
Fungi are well known for their metabolic versatility, whether it is the degradation of complex organic substrates or the biosynthesis of intricate secondary metabolites.
Linder T.
europepmc   +3 more sources

Identification and evolution of glucosinolate sulfatases in a specialist flea beetle. [PDF]

Sci Rep, 2019
Ahn SJ, Betzin F, Gikonyo MW, Yang ZL, Köllner TG, Beran F.   +5 more
europepmc   +3 more sources

Arylsulfatases and neuraminidases modulate engagement of CCR5 by chemokines by removing key electrostatic interactions. [PDF]

Sci Rep
Pinheiro I, Calo N, Paolini-Bertrand M, Hartley O.   +3 more
europepmc   +2 more sources

Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer. [PDF]

World J Clin Cases, 2019
Kovacs Z, Jung I, Szalman K, Banias L, Bara TJ, Gurzu S.   +5 more
europepmc   +2 more sources