Structural insights into manganese-dependent arylsulfatase from Enterococcus faecium and its catalytic promiscuity [PDF]
mBioCatalytic promiscuity, wherein enzymes catalyze multiple distinct reactions by stabilizing various transition states, is well documented in the alkaline phosphatase superfamily.
Lulu Guo +9 more
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Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid Eulalia sp. onto Ovarian Cancer Cells [PDF]
Marine Drugs, 2021 As Yondelis joins the ranks of approved anti-cancer drugs, the benefit from exploring the oceans’ biodiversity becomes clear. From marine toxins, relevant bioproducts can be obtained due to their potential to interfere with specific pathways. We explored
Ana P. Rodrigo +7 more
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Arylsulfatases and neuraminidases modulate engagement of CCR5 by chemokines by removing key electrostatic interactions [PDF]
Scientific ReportsThe chemokine receptor CCR5 is known to exist in cell surface subpopulations that differ in their capacity to engage ligands. One proposed explanation for this phenomenon is the presence of CCR5 species with different levels of post-translational ...
Inês Pinheiro +3 more
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Structural and Functional Integration of Tissue-Nonspecific Alkaline Phosphatase Within the Alkaline Phosphatase Superfamily: Evolutionary Insights and Functional Implications [PDF]
MetabolitesPhosphatases are enzymes that catalyze the hydrolysis of phosphate esters. They play critical roles in diverse biological processes such as extracellular nucleotide homeostasis, transport of molecules across membranes, intracellular signaling pathways ...
Iliass Imam +5 more
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Detection of bacterial sulfatase activity through liquid- and solid-phase colony-based assays [PDF]
AMB Express, 2017 Bacterial arylsulfatases are crucial to biosynthesis in many microorganisms, as bacteria often utilize aryl sulfates as a source of sulfur. The bacterial sulfatases are associated with pathogenesis and are applied in many areas such as industry and ...
Hey Young Yoon +3 more
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Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding. [PDF]
Acta Crystallogr D Struct Biol, 2022 This work was supported by the Spanish Ministry of Science and Innovation/FEDER grants PID2020-116261GB-I00 (JAG) and RTI2018-097991-B-I00 (JLN), Secretaria General de Universidades, Investigacion y Tecnologia, Junta de Andalucia (PY20-00149 and UAL18 ...
Gavira JA +6 more
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Transition-State Interactions in a Promiscuous Enzyme: Sulfate and Phosphate Monoester Hydrolysis by Pseudomonas aeruginosa Arylsulfatase [PDF]
, 2019 Pseudomonas aeruginosa arylsulfatase (PAS) hydrolyzes sulfate and, promiscuously, phosphate monoesters. Enzyme-catalyzed sulfate transfer is crucial to a wide variety of biological processes, but detailed studies of the mechanistic contributions to its ...
Bert van Loo +6 more
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Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B.
Journal of Biological Chemistry, 1990 A 2.2-kilobase cDNA clone for human arylsulfatase B (ASB) and several genomic clones were isolated and sequenced. The deduced amino acid sequence of 533 amino acids contains a 41-amino acid N-terminal signal peptide and a mature polypeptide of 492 amino acid residues.
C Peters +8 more
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Localization of arylsulfatase in Pseudomonas C12B [PDF]
Applied and Environmental Microbiology, 1977 Arylsulfatase was released almost completely from intact cells of Pseudomonas C12B after osmotic shock or after treatment with lysozyme. These results suggest that the enzyme is cell wall associated in this soil isolate.
John W. Fitzgerald, J. Richard George
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Arylsulfatase I is a prognostic biomarker for head and neck squamous cell carcinoma and Pan-cancer. [PDF]
J Clin Lab Anal, 2022 Shen Y +8 more
europepmc +2 more sources