Structural insights into manganese-dependent arylsulfatase from Enterococcus faecium and its catalytic promiscuity [PDF]
mBioCatalytic promiscuity, wherein enzymes catalyze multiple distinct reactions by stabilizing various transition states, is well documented in the alkaline phosphatase superfamily.
Lulu Guo +9 more
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Arylsulfatases and neuraminidases modulate engagement of CCR5 by chemokines by removing key electrostatic interactions [PDF]
Scientific ReportsThe chemokine receptor CCR5 is known to exist in cell surface subpopulations that differ in their capacity to engage ligands. One proposed explanation for this phenomenon is the presence of CCR5 species with different levels of post-translational ...
Inês Pinheiro +3 more
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Structural and Functional Integration of Tissue-Nonspecific Alkaline Phosphatase Within the Alkaline Phosphatase Superfamily: Evolutionary Insights and Functional Implications [PDF]
MetabolitesPhosphatases are enzymes that catalyze the hydrolysis of phosphate esters. They play critical roles in diverse biological processes such as extracellular nucleotide homeostasis, transport of molecules across membranes, intracellular signaling pathways ...
Iliass Imam +5 more
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Detection of bacterial sulfatase activity through liquid- and solid-phase colony-based assays [PDF]
AMB Express, 2017 Bacterial arylsulfatases are crucial to biosynthesis in many microorganisms, as bacteria often utilize aryl sulfates as a source of sulfur. The bacterial sulfatases are associated with pathogenesis and are applied in many areas such as industry and ...
Hey Young Yoon +3 more
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Author Correction: Arylsulfatases and neuraminidases modulate engagement of CCR5 by chemokines by removing key electrostatic interactions [PDF]
Scientific ReportsInês Pinheiro +3 more
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Agronomy, 2023 Proteases, catalysing protein hydrolysis, and arylsulfatases, catalysing sulfate-ester hydrolysis, are key microbial enzymes for N and S mineralization in soil.
Nicolas Romillac +3 more
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Pseudo arylsulfatase A deficiency Biosynthesis of an abnormal arylsulfatase A [PDF]
FEBS Letters, 1987 Pseudo arylsulfatase A deficiency, an asymptomatic condition, and metachromatic leukodystrophy, a severe neurodegenerative disease, are both associated with profound reductions of arylsulfatase A activity in man. We now report that with metabolic labelling, cultured pseudo deficient cells synthesized about 20% of the normal amount of arylsulfatase A at
Ameen, Mohammed, Chang, Patricia L.
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Marine Drugs, 2021 As Yondelis joins the ranks of approved anti-cancer drugs, the benefit from exploring the oceans’ biodiversity becomes clear. From marine toxins, relevant bioproducts can be obtained due to their potential to interfere with specific pathways. We explored
Ana P. Rodrigo +7 more
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Profiling Urinary Sulfate Metabolites With Mass Spectrometry
Frontiers in Molecular Biosciences, 2022 The study of urinary phase II sulfate metabolites is central to understanding the role and fate of endogenous and exogenous compounds in biological systems.
Christopher C. J. Fitzgerald +8 more
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Medicine in Drug Discovery, 2020 Aims: Minoxidil is a hair growth drug for treating androgenetic alopecia. Although minoxidil is generally administered as a topical formulation, this prodrug must be converted to its active form (minoxidil sulfate) by sulfotransferase in hair follicle ...
Mio Ichida +4 more
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